Mesoblast Limited (MESO) develops cell-based medicines.
MESO has leveraged its proprietary technology platform based on mesenchymal lineage adult stem cells to establish a portfolio of late-stage product candidates. Its allogeneic cell product candidates target advanced stages of diseases with high and unmet medical needs, including cardiovascular conditions, immunologic and inflammatory conditions, orthopedic disorders, and oncology and hematology conditions.
MESO’s products under the Phase III clinical trials include MPC-150-IM for chronic and end-stage heart failure; MPC-06-ID for chronic low back pain; and MSC-100-IV for acute graft versus host disease in children. It is also developing MPC-300-IV that is in Phase II clinical trials for the treatment of biologic refractory rheumatoid arthritis, and diabetic kidney diseases and type 2 diabetes.
MESO has a collaboration agreement with JCR Pharmaceuticals Co., Ltd. It has operations in the United States, Australia, Singapore, and Switzerland. Mesoblast Limited was founded in 2004 and is headquartered in Melbourne, Australia.
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Insight, foresight and recommendation
Mesoblast (MESO) – January '18 opened at $5.84, slipping in february to $5.50 yet falling to a low of $4.91 followed by an upswing to $5.52 on 2/21. Volume has been low as has platform news. MESO ended the recent quarter with $62.9M. Mesoblast also has a $90M equity facility that can be used over the next two years. Trials include: GVHD, MSC-100-IV: The open-label P3 trial in pediatric patients with steroid-refractory acute GVHD is expected to complete enrollment in 4Q17, with the primary endpoint data (day 28 readout) in 1Q18, followed by day 100 survival data in 2Q18. Heart failure (HF), MPC-150-IM: The P3 study in class II-III HF has enrolled over 400 patients and is on track to complete enrollment (N=600) in 2H18. The P2b study in end-stage HF (Class IV) completed enrollment (N=159) in 3Q17 with data readouts expected in 1Q18 and 3Q18. Disc Degeneration (DD), MPC-06-ID: The P3 (N=360) study is expected to complete enrollment in early 1Q18. The study is evaluating durable pain reduction and functional improvement (aiming for similar results observed in the N=100 P2 study). Rheumatoid Arthritis (RA), MPC-300-IV: Data in the P2 study demonstrated durable efficacy in anti-TNF refractory patients going out to 52 weeks. The totality of the data will be used to design a P3 program, though timing has not been disclosed. Mesoblast's strong IP estate has to be better valued …buy
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Editor and Publisher ... Henry McCusker enters his tenth (10th) year at RegMed Investors