Indication intelligence, analysis and sector perception

RMi Research Note: Japan’s Takeda (TAK) exits cell and gene therapy (CGT) research with $395 M write-off

October 12, 2025

In 2020, they looked and now in 2025, vaccines will become a core business. Reuters reported “The move marks a significant shift for the Japanese drugmaker, which had spent years trying to build a presence in cell therapy, particularly in cancer treatment.” TAK will focus on small molecule drugs, biologics and antibody-drug conjugates – areas it believes can deliver innovative medicines to patients more quickly and at greater scale. Takeda's current 5 core businesses are oncology, gastroenterology, neuroscience, rare diseases, and plasma-derived therapies  

RMi Research Note: Harvard Apparatus GT (OTCQB): Who is wasting lipstick on this pig?

October 9, 2025

Who is pumping the volume thus the price, after the usual small and inching volume or no volume  Challenging and questionable "aspects" state the obvious – a Ponzi Scheme! They’re BROKE filing with yet another PPM unfulfilled! What valuation model would even/ever justify a PPM pricing? Accumulated deficit to date= $103.2 M in 12 years WHO is their major shareholder – DST Capital and itsDAILY buyer, OTCQB: HRGN’s in-house fund run by its president Hong Yu, funded by Mrs. bin (Zhao) of Weston, Mass. ??? U.S. investors BEWARE, forewarned is forearmed?              

RMi Research Note: uniQure NV (QURE) Closes 6.736 M share offering priced at $47.50

September 29, 2025

For gross proceeds of $345 M QURE closed up +$5.09 or +9.37% to $59.40 with an aftermarket pricing of -$1.25 or -2.10% to $58.15 QURE had soared by 291% week-on-week to climb to a new all-time high based on astronomical performance of its delivered gene therapy treatment AMT-130 for Huntington’s disease.