March 8, 2019 6:14pm

With volume slipping lower as the IBB also slipped (-0.49) again

It’s not about sentiment, confidence or sector breadth but, pessimism and anticipation of increasing LPS (loss-per-share) quarterly earnings as smaller caps begin releasing

Pre-open indications: 4 HITs and 3 MISS


It’s not hard to be right so often, it’s about refining expectation, defining insight and NOT being indentured to ANY financial institution! 

That’s why my “quantamental” blend of styles; must become the “tool” for investors and traders to portfolio enrichment.


Markets and indexes:

  • The Dow closed down -22.99 points or -0.09% to 25,450.24
  • The S&P closed down -5.86 points or -0.21% to 2,743.07
  • The NASDAQ was down -13.32 points or -0.18% to 7,408.14



The sector closed up having been below the waterline for most of the session.

The indexes posted their biggest weekly declines of the year. The major indexes all dropped more than 2% this week. The NASDAQ snapped a 10-week winning streak, while the Dow notched its second weekly decline of the year.

It has seemed to be a long week as the sector alternating in their closes.


Pre-open post, “caution is in the air after alternating closes in the first full week of a new month. Sector focus is on ending the week without further share pricing downfalls!”


The advance/decline line scenario of 45 covered companies:  

  • The open was negative with the A/DL to 10/30 and 5 flats;
  • The mid-day was negative with an A/DL of 15/27 and 3 flats;
  • The close was positive with an A/DL of 22/20 and 3 flats;


Pre-open indications: 4 HITs and 3 MISS

  • Alnylam Pharmaceuticals (ALNY) closed down -$0.10 – miss;
  • CRISPR Therapeutics (CRSP) closed down -$1.00 – hit;
  • Editas Medicine (EDIT) closed down -$0.26 – hit;
  • Intellia Therapeutics (NTLA) closed up +$0.15 – hit;
  • BioTime (NYSEMKT: BTX) closed up +$0.03 – hit;
  • ReNeuron (RENE.L) closed up +$4.00 – miss;
  • Verastem Oncology (VSTM) closed down -$0.02 – miss;


Bouncing to the upside:  

  • RENE.L (+$4.00), BOLD (+$1.38), QURE (+$1.22), IONS (+$0.65) and STML (+$0.60)

Leading the pack to the downside:

  • FIXX (-$1.71), RGNX (-$1.35), BMRN (-$1.32), AXGN (-$1.31) and CRSP (-$1.00)

Closing FLAT:  



Tonight’s percentage (%) indicators: 

  • Range of the 22 upside was +0.06% (CLLS) to +10.57% (CUR) while the 20 downside ranged from -0.06% (VYGR) to -7.95% (ADVM).

Volume stat: 

  • 8 out of the 22 upside had higher (than the 3 month average) volume
  • 1 out of the 20 downside experienced greater volume (than the 3 month average)



The iShares NASDAQ Biotechnology (IBB) indicator:

  • Friday was down -0.49% after NOT indicating;
  • Thursday was down -0.66% after NOT indicating;
  • Wednesday was down -3.13% after NOT indicating;
  • Tuesday was down -0.52% after NOT indicating;
  • Monday was down -0.96% after indicating a POSITIVE +0.4% in the pre-market;
  • Last Friday was up +2.10% after NOT indicating;


March sessions:

Friday closed POSITIVE with 20 decliners, 22 advancers and 3 flats;

Thursday closed POSITIVE with 14 decliners, 29 advancers and 2 flats;

Wednesday closed NEGATIVE with 39 decliners, 5 advancers and 1 flat;

Tuesday (3/4) closed POSITIVE with 17 decliners, 23 advancers and 5 flats;

Monday (3/1) closed NEGATIVE with 24 decliners, 18 advancers and 3 flats;

Friday (3/1) closed POSITIVE with 11 decliners, 32 advancers and 2 flats;


Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.

Henry McCusker, the editor and publisher of RegMed Investors does not hold or have positions in securities referred to in this publication.