August 26, 2022 7:44am

I’d be watching bond volatility and yield curves which could stimulate turbulent markets

Pre-open indications: I am abstaining yet, will throw-out some “coulda’s” – 3 Negative Indications or maybe “wooda’s” - 2 positive Indications and 1 Puff/Pump/Promote

RMi outlines a daily bell ringing of “indications” about what you need to know; it’s what could happen or materialize after the opening and what might happen during the session.

More frequently right than consequentially wrong; there is VALUE out there. What I provide is an intelligence daily.

The 8:00 A.M., ET edition

Remember that overnight and pre-open actions in futures don't necessarily translate into actual trading in the coming day’s session.


Dow futures are DOWN -0.22% or (-70 points), S&P futures are DOWN -0.35% (-14 points) and NASDAQ futures are DOWN -0.45% (-60 points) early in the pre-open – so far,


Stock futures are slipping,

European markets were mixed, the pan-European Stoxx 600 was 0.2% lower by late morning, having given back opening gains of around 0.5%.

Asia-Pacific markets advanced higher.



Thursday, the Dow jumped about 322.55 points, the S&P 500 gained 55.82 points, as the Nasdaq advanced207.74

The major averages are on pace for their second straight down week; the Dow is on track for a 1.2% decline, the S&P 500 is down -0.7% and Nasdaq -0.05%.

Economic Data Docket: U.S. household spending, University of Michigan’s consumer sentiment for August and Powell’s Fed’s guidance or not.


RegMed Investors’ (RMi) closing bell: “why is the sector alternating between momentum driven upside and downside? Questions arise as CEOs do LESS to assure their investors while forgetting shareholders are co-owners?” …

Ebb and flow –

Q3/22 – August – 11 positive and 8 negative close

July - 1 holiday, 10 negative and 10 positive closes

Q2/22 –

June – 1 holiday, 9 positive and 11 negative closes

·         May - 11 positive and 10 negative closes

·         April - 1 holiday, 6 positive and 13 negative closes


·         March – 13 negative and 10 positive closes

·         February stats: 11 negative, 8 positive closes and 1 holiday

·         January stats: 2 holidays, 1 neutral, 13 negative and 6 positive closes


Companies in my headlights – It’s your decision; I provide ideas and context: INDICATIONS

Negative Indications:

Beam Therapeutics (BEAM) closed up +$2.31 to $62.15 with a negative -$1.15 or -1.85% preopen indication,

BioLife Solutions (BLFS) closed up +$0.94 to $24.30 with a negative -$0.80 or -3.29% pre-open indication,

Voyager Therapeutics (VYGR) closed up +$0.22 to $6.36 with a negative -$0.20 or -3.14% pre-open indication


Positive Indication:

Agenus (AGEN) closed down -$0.10 to $2.89 with a positive +$0.01 or +0.35%

bluebird bio (BLUE) closed down -$0.16 to $6.14 with a positive +$0.17 or +2.77% pre-open indication


Puff/Pump and Promote: Maintaining SELL

Biostage (OTCQB: BSTG) closed down -$0.40 (was -$2.20) trading 7,913 shares <3-month average = 1,211> after Wednesday’s +$2.20 to $7.20 with 13,882 shares traded after Tuesday’s +$0.45 with 1,249 shares traded after Monday’s flat following Friday’s $0.00 with 37 shares traded, Thursday’s -$0.15 with 790 shares traded, Wednesday’s +$0.15 with 1,035 shares traded, Tuesday’s flat (with 1,824 shares traded), and last Monday flat.

Its BOD approved on 7/28 amending and restating their Certificate of Incorporation to affect a reverse split of the issued and outstanding common stock at a ratio of not less than 1-for-1.25 and not greater than 1-for-5. What about all those PPM (private placements) as an offering follows?

·         BSTG seems to have the ONLY avenue to finance to utilize non-U.S. Chinese investors? Are we in favor of Beijing funding and continue to control BSTG in our own country? Another question, makes one wonder, Newbridge Securities?

·         How much lipstick is a lot on this pig with an almost 4-year-old IND and NO clinical trial initiation?

·         New CFO, number #7 for the chute?

·         WATCH and be ready for a BIG reverse of shares to enable offering from multiple private placements as it tries to facilitate an offering with Newbridge Securities?


The BOTTOM LINE: I try to keep it simple … and short!

Some quotes to be remembered, “The real question that should be asked is how many companies are at the end of sentiments leash? Start by looking at cell and gene therapy companies trading below cash!”

How many companies are LOSING the investment high ground?


 Investors seem to don't want to commit heavily before today's speech from Fed chief Jerome Powell. 

As I have written, I devote a lot of time to the direction of the sector to “reckon” the geography of my coverage group.”

With the cell and gene therapy sector shows more signs of drama of upside movement alternating to continued weakness, investors should be playing more defense with existing positions.

That doesn't mean you should flee entirely to cash, but investors make sure gains don't evaporate thus … be quick to drop losing positions.

Whether information or intelligence is good, bad or somewhere in between; RMi’s daily report is a primer that may say little or a lot; yet it serves as insurance that all indications are being examined and evaluated.


Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice.

All investments are subject to risks. Investors should consider investment objectives.

Regulation Analyst Certification (Reg AC): The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and its or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed in this report.

Henry McCusker, the editor and publisher of RegMed Investors does not hold or have positions securities referred to in this publication.