September 8, 2022 7:47am

Realize some profit and build more cash from any new highs

Indications: 2 Positive Indications, 3 Negative Indications and 1 Pump/Promotes

RMi outlines a daily bell ringing of “indications” about what you need to know; it’s what could happen or materialize after the opening and what might happen during the session.

More frequently right than consequentially wrong; there is VALUE out there. What I provide is an intelligence daily.

The 8:00 A.M., ET edition

Remember that overnight and pre-open actions in futures don't necessarily translate into actual trading in the coming day’s session.


Dow futures are UP +0.06% or (+17 points), S&P futures are DOWN -0.01 (-1 point) and NASDAQ futures are DOWN -0.09% (-11 points) early in the pre-open – so far,


Stock futures were up, mixed and headed lower on Thursday,

European markets opened higher,

Asia-Pacific markets were mixed. As Chinese "Components and Composites" struggled



Last night, the Dow closed UP +435.98 points (+1.98); the S&P closed UP +71.68 points (+1.83%) while the Nasdaq closed UP +246.99 points (+2.14%)

For the week, the Dow gained 1.4% and is now up 0.8%, the S&P 500 climbed 1.8% and is now up 1.4% while the Nasdaq rose 2.1% and is now up 1.4% for the week. The Russell 2000 small caps gained 2.2% and is now up 1.2% for the week.

It was the best day since 8/10 for all three (3) averages, and the Nasdaq snapped a seven (7) day losing streak.

A quote to be considered and remembered, “Recession risk is rising and we have been moving more defensive in our portfolios as a result. However, high inflation means that traditional ‘risk off’ strategies such as cash and government bonds can create a drag on total return,” Lauren Goodwin, economist and portfolio strategist at New York Life Investments, said in a note to clients.

Economic Data Docket: jobless claims data; economists expect 235,000 initial unemployment claims, up slightly from 232,000 in the previous week.


RegMed Investors’ (RMi) Wednesday’s closing bell: “A reaction to the market while electronic trading and algorithms recoup their sell “rules”. As I had stated this a.m., “arguably the cell and gene therapy sector is due for a bounce” …


Ebb and flow –

Q3/22 – September – 1 holiday, 2 positive and 2 negative closes

·         August – 1 neutral, 11 positive and 11 negative closes

·         July - 1 holiday, 10 negative and 10 positive closes

Q2/22 –

·         June – 1 holiday, 9 positive and 11 negative closes

·         May - 11 positive and 10 negative closes

·         April - 1 holiday, 6 positive and 13 negative closes


·         March – 13 negative and 10 positive closes

·         February stats: 11 negative, 8 positive closes and 1 holiday

·         January stats: 2 holidays, 1 neutral, 13 negative and 6 positive closes


Companies in my headlights – It’s your decision; I provide ideas and context: INDICATIONS

Positive Indications:

uniQure NV (QURE) closed up +$1.35 to $20.85 after Tuesday’s -$1.116 after Monday’s holiday following Friday’s $20.66 and Thursday’s $20.67 with a positive +$0.78 or +3.74% pre-open indication,

Fate Therapeutics (FATE) closed up +$2.01 to $27.31 after Tuesday’s $25.30, Monday’s holiday, Friday’s $26.72 and last Thursday’s $27.03 with a positive +$0.64 or +2.345 pre-open indication,


Negative Indications:

bluebird bio (BLUE) closed up +$0.49 to $5.86 after Tuesday’s $6.37, Friday’s $6.83 and Thursday’s $6.55 with a negative -$0.05 or 0.73% pre-open indication,

Chinook Therapeutics (KDNY) closed up +$1.12 to $21.47 after Tuesday’s $20.35 and Friday’s $21.22 with a negative -$0.37 or -1.72% pre-open indication,

Intellia Therapeutics (NTLA) closed up +$2.24 to $57.61 after Tuesday’s $55.37, Monday’s holiday and Friday’s $56.01 and last Thursday’s $59.97 with a negative -$0.61 or -1.06% pre-open indication,


Puff/Pump and Promote: Maintaining SELL

Biostage (OTCQB: BSTG) closed down -$0.60 after Tuesday’s flat with 34 shares traded on Tuesday, Monday’s holiday following Friday’s $0.00 Thursday’s $0.00 and last Wednesday’s $0.00 <3-month average = 1,617>,

·         How much lipstick is a lot on this pig with an almost 4-year-old IND and NO clinical trial initiation?

·         WATCH and be ready for a BIG reverse of shares to enable offering from multiple private placements as it tries to facilitate an offering with Newbridge Securities?



The BOTTOM LINE: I follow the dictum, quoting Churchill that “short words are best, and the old words when short are best of all.”

I try to keep it simple … and short as I love my coverage list – yet, the truth will set investors free from electronic and algorithm control!

September started with 1 holiday, 2 positive and 2 negative closes; August is over with 1 neutral, 11 positive and 11 negative closes while last week which ended the month.

As I continually question, “The real question that should be asked is how many companies are at the end of sentiments …  leash? Start by looking at cell and gene therapy companies trading below cash!” 

Second Question, “How many companies are LOSING the investment high ground? TOO MANY” …!!!

Investors need to come to terms of the cell and gene therapy sector’s state of affairs and health as individual company’s actions cast doubts upon sentiment as reflected by August’s final accounting of positive and negative closes.

Companies NEED BETTER outreach to investors which means … NOT to enrich themselves at shareholder’s expense!

CEO salaries, spending the G&A are totally OUT-OF-WHACK; these are companies are in the development stage and will be for years without products in most cases not like the tech companies, who CEOs and management teams think they should be compared to for bi-weekly cash and “beanies”!

When it comes time to invest or even hold onto an investment; I’d say … focus on what percentage ownership of stock … NOT options CEOs and management teams own versus their salary and bonus.

Also, investors can’t afford the outsized valuation price targets by I-Banks research and believe that CEOs are “accomplices” to over-estimating expectation and guidance in regard to valuation

The only thing investors are able to hang to at that point is HOPE – which is not a technical or fundamental indicator.  Keep your eyes on historical pricings that, haven’t responded to I-Bank research price targets.

As I have written, “I devote a lot of time to the direction of the sector to reckon the geography of my coverage group.”

That doesn't mean you should flee entirely to cash, but investors make sure gains don't evaporate thus … be quick to drop losing positions.

Whether information or intelligence is good, bad or somewhere in between; RMi’s daily report is a primer that may say little or a lot; yet it serves as insurance that all indications are being examined and evaluated.


Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice.

All investments are subject to risks. Investors should consider investment objectives.

Regulation Analyst Certification (Reg AC): The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and its or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed in this report.

Henry McCusker, the editor and publisher of RegMed Investors does not hold or have positions securities referred to in this publication.