May 19, 2025 8:00am

As we meander through Moody’s debt downgrade or a policy issue, does a cruel one-off effect a weak economic data flow? Leading the premarket losses Monday were key tech stocks that would be hurt the most if rising yields slowed the economy and hurt investors’ risk appetites 

News: Intellia Therapeutics (NTLA +$1.42 or +0.50% pre-open) positive 2-year follow-up data from the ongoing P1 (MAGNITUDE-2) trial of investigational nexiguran ziclumeran (nex-z) for the treatment of hereditary ATTR amyloidosis with polyneuropathy (ATTRv-PN). Transthyretin amyloidosis, or ATTR amyloidosis, is a rare, progressive and fatal disease. Hereditary ATTR (ATTRv) amyloidosis occurs when a person is born with mutations in the TTR gene, which causes the liver to produce structurally abnormal transthyretin (TTR) protein with a propensity to misfold.

Pre-open Indications: 5 Negative and 2 positive Indications

No false narratives or fake news; to read insights and analysis on the latest sector action, check out Pre-Open Brief

Never leave an investor uninformed!

Remember that overnight and pre-open actions’ futures and markets doesn’t necessarily translate into actual trading in today’s market session.

“I also hate to be so negative or contrarian but, this is a NO spin zone and truth is its product; I can always be WRONG but, I am mostly EARLY!”

My interpretation of the morning’s numbers is written to be informative; it’s built on what happened to make “it” happen today!

 

Friday’s night’s … RegMed Investors (RMi) Closing Bell: Cover, cover … https://www.regmedinvestors.com/articles/13923

RegMed Investors (RMi) Research Note: Harvard Apparatus GT (OTCQB: HRGN), The latest, WHAT happens to OTCQB: HRGN if the White House and the new head of the SEC starts to "DELIST" Chinese companies??? … Newest happening, public accountants walk … https://www.regmedinvestors.com/articles/13812

 

Monday: The pre-open Dow futures are DOWN -0.66% or (-288 points), the S&P futures are DOWN -1.16% or (-69 points) and the Nasdaq futures are DOWN -1.58% or ( -339 points)

  • Stock futures tumbled on Monday as a downgrade of the U.S.′ credit rating by Moody’s caused Treasury yields to spike.
  • European markets were down
  • Asia-Pacific markets fell negative

 

Henry’omics: We need to more than consider the economic environment to comprehend the micro re “our” universe of cell and gene therapy companies

A start to the new week and the reason why … Friday, Moody’s Ratings downgraded the U.S. sovereign credit rating by one level from Aaa to Aa1, citing mounting challenges in funding the federal budget deficit and the increasing cost of refinancing debt in a high-interest-rate environment.

Week to date, the S&P 500 was up +5.3%, and the Dow had gained +3.4% and the Nasdaq jumped +0.52%.

  • Friday: The Dow closed UP +331.99 points or +0.78%, the S&P closed UP +41.45 points or +0.70% while the Nasdaq closed UP +98.78 points or +0.52%
  • Thursday’s advance/decline line opened with a negative 9 incliner, 23 decline and 3 flats ending with a positive close of 24 incliners, 10 decliners and 1 flat         
  • Wednesday: The Dow closed DOWN -89.37 points or -0.21%, the S&P closed UP +6.03 points or +0.10% while the Nasdaq closed UP +136.72 points or +0.72%
  • Tuesday: The Dow closed DOWN -269.67 points or -0.64%, the S&P closed UP +42.36 points or +0.72% while the Nasdaq closed UP +301.74 points or +1.61%
  • Monday: The Dow closed UP +1,160.72 points or +2.81%, the S&P closed UP +164.28 points or +3.26% while the Nasdaq closed UP +779.43 points or +4.35%

Economic Data Docket: housing starts data and the University of Michigan’s consumer sentiment survey.

 

Q2 – May – 6 negative and 6 positive closes

  • Q2 - April – 10 negative and 11 positive closes

Q1/25

  • March, 10 positive and 11 negative closes
  • February – 12 holiday, 11 negative and 7 positive closes
  • January - 2 holidays, 1 market close, 10 negative and 10 positive closes

 

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

Better part of valor to not lead any investor to temptation; yet again, I am passing on forecasting the daily indications as to expectation while the aftermarket blanked while the pre-open waits for the …  econs, it is still a mix of ups, downs and just uncertainty

Some, Negative pre-open leanings:

  • Alnylam Pharmaceuticals (ALNY) – a negative -$1.42 or -0.50% pre-open
  • Beam Therapeutics (BEAM) -- a negative -$0.23 or -1.29% pre-open
  • Blueprint Medicine (BPMC) --- a negative -$0.56 or -0.55% pre-open
  • CRISPR Therapeutics (CRSP) - -- a negative -$0.70 or -1.81% pre-open
  • Ultragenyx Pharmaceuticals (RARE) - a negative -$0.11 or -0.31% pre-open

And some, Positives:

  • Moderna (MRNA) - a positive +$0.60 or +2.41% pre-open
  • Intellia Therapeutics (NTLA) – a positive +$1.42 or +0.50% pre-open

 

The BOTTOM LINE: When you want to decant or fill your portfolio carafe, always consider it, a glass half-full

May ‘25: understand the “flow” of bad market and economic karma…

  • 5/16 - Friday closed positive with 29 positive, 3 negative and 3 flats
  • 5/15 – Thursday closed positive with 24 positive, 10 negative and 1 flat
  • 5/14 – Wednesday closed negative with 8 positive, 25 negative and 2 flats
  • 5/13 – Tuesday closed negative with 6 positive, 28 negative and 1 flat
  • 5/12 – Monday closed positive with 30 positive, 3 negative and 2 flats
  • 5/9 – Friday closed negative with 10 positive, 23 negative and 2 flats
  • 5/8 - Thursday closed positive with 25 positive, 8 negative and 2 flats
  • 5/7 – Wednesday closed positive with 16 positive, 15 negative and 4 flats
  • 5/6 – Tuesday closed negative with 2 positive, 31 negative and 2 flats
  • 5/5 - Monday closed negative with 9 positive, 23 negative and 3 flats
  • 5/2 – Friday closed positive with 24 positive, 8 negative and 3 flats
  • 5/1 – Thursday closed negative with 14 positive, 19 negative and 2 flats

 

Brace ourself for a few more economics ... this week and their down trending affect?

 

Welcome to my world of defining the “grey’ in our universe!

  • The sector is what it is, until it isn’t and even then, it doesn’t seem to be… as NOT much changes as the sector’s share pricing rides the waves of volatility, algorithms, electronic trading and short covering.
  • I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

 

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC): The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed in this report.

Henry McCusker, the editor and publisher of RegMed Investors could hold or have positions securities referred to in this publication and he will NOTIFY investors of holdings.