RegMed Investors’ (RMi) pre-open: let it go, retail investors have no control

May 23, 2025 8:37am

Treasury’s yield will determine the course, while volatility is a formal measure of risk

Yesterday Thursday, 3-major averages closed mixed as investors grappled with fears of rising rates and worries about a ballooning U.S. deficit. The 30-year Treasury yield hit its highest since 2023 as lawmakers passed a bill that investors fear could worsen the U.S. deficit.

A 3-day weekend ahead, can’t come soon enough, market closed for Memorial Day on Monday!

Pre-open Indications: 4 Negative and 1 Positive

No false narratives or fake news; to read insights and analysis on the latest sector action, check out Pre-Open Brief

Never leave an investor uninformed!

Remember that overnight and pre-open actions’ futures and markets doesn’t necessarily translate into actual trading in today’s market session.

“I also hate to be so negative or contrarian but, this is a NO spin zone and truth is its product; I can always be WRONG but, I am mostly EARLY!”

My interpretation of the morning’s numbers is written to be informative; it’s built on what happened to make “it” happen today!

Thursday’s night’s … RegMed Investors (RMi) Closing Bell: sessions keep alternating into the worse and better of pricing … https://www.regmedinvestors.com/articles/13930

RegMed Investors (RMi) Research Note: Harvard Apparatus GT (OTCQB): No partner, No cash, NO runway, extensive liabilities and debts to past employee and university associations … https://www.regmedinvestors.com/articles/13812

Friday: The pre-open Dow futures are DOWN -1.9% or (-542 points), the S&P futures are DOWN -1.45% or (-85 points) and the Nasdaq futures are -1.83% or (-388 points)

• Stock futures were slipping down pre-open on Friday,
• European markets opened higher,
• Asia-Pacific markets were mixed

Henry’omics: We need to more than consider the economic environment to comprehend the micro re “our” universe of cell and gene therapy companies

Thursday: The Dow closed DOWN -0.00 points or -1.35%, the S&P closed DOWN -2.60 points or -0.04% while the Nasdaq closed UP +53.09 points or +0.28%

Wednesday: The Dow closed DOWN -816.80 points or -1.91%, the S&P closed DOWN -95.85 points or -1.61% while the Nasdaq closed DOWN -270.07 points or -1.41%

Tuesday: The Dow closed DOWN -114.83 points or -0.27%, the S&P closed DOWN -23.14 points or -0.39% while the Nasdaq closed DOWN -72.75 points or -0.38%

Monday: The Dow closed UP +137.33 points or +0.32%, the S&P closed UP +5.22 points or -0.09% while the Nasdaq closed UP +4.36 points or +0.02%

Economic Data Docket:  building permits and new home sales data

Q2 – May – 7 negative and 9 positive closes

• Q2 - April – 10 negative and 11 positive closes

Q1/25

• March, 10 positive and 11 negative closes
• February – 12 holiday, 11 negative and 7 positive closes
• January - 2 holidays, 1 market close, 10 negative and 10 positive closes

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

Better part of valor to not lead any investor to temptation; yet again, I am passing on forecasting the daily indications as to expectation while the aftermarket blanked while the pre-open waits for the …  econs, it is still a mix of ups, downs and just uncertainty

Pre-open indications:

• CRISPR Therapeutics (CRSP) closed up +$0.54 with a negative -$0.42 or -1.12%
• Intellia Therapeutics (NTLA) closed up +$0.26 with a negative -$0.08 or -0.85%
• Moderna (MRNA) closed up +0.92 with a negative -$0.01 or -0.04%
• Verve Therapeutics (VERV) closed up +0.15 with a negative -$0.03 or -0.6849%
• Sold Biosciences (SLDB) closed up +$0.19 with a positive +0.05 or +1.73%

The BOTTOM LINE: When you think of wanting to decant (selling) or fill (buying) your portfolio carafe, always consider it, a glass half-full

May ‘25: understand the “flow” of bad market and economic karma…

• 5/22 – Thursday closed positive with 19 positive, 14 negative and 2 flats
• 5/21 – Wednesday closed negative with 3 positive, 30 negative and 2 flats
• 5/20 – Tuesday closed positive with 23 positive, 9 negative and 3 flats
• 5/19 - Monday closed positive with 23 positive, 12 negative and 1 flat

• 5/16 - Friday closed positive with 29 positive, 3 negative and 3 flats
• 5/15 – Thursday closed positive with 24 positive, 10 negative and 1 flat
• 5/14 – Wednesday closed negative with 8 positive, 25 negative and 2 flats
• 5/13 – Tuesday closed negative with 6 positive, 28 negative and 1 flat
• 5/12 – Monday closed positive with 30 positive, 3 negative and 2 flats

• 5/9 – Friday closed negative with 10 positive, 23 negative and 2 flats
• 5/8 - Thursday closed positive with 25 positive, 8 negative and 2 flats
• 5/7 – Wednesday closed positive with 16 positive, 15 negative and 4 flats
• 5/6 – Tuesday closed negative with 2 positive, 31 negative and 2 flats
• 5/5 - Monday closed negative with 9 positive, 23 negative and 3 flats

• 5/2 – Friday closed positive with 24 positive, 8 negative and 3 flats
• 5/1 – Thursday closed negative with 14 positive, 19 negative and 2 flats

Brace ourself for more earnings and economics and their down trending affect?

Welcome to my world of defining the “grey’ in our universe!

• The sector is what it is, until it isn’t and even then, it doesn’t seem to be… as NOT much changes as the sector’s share pricing rides the waves of volatility, algorithms, electronic trading and short covering.
• I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC): The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.