May 27, 2025 7:45am

Our share price need to go faster and further after exiting alternating bottoms

However, expectation seems to be dependent on new flow enhances by tariff plays, economics, micro and macro

Pre-open Indications: 1 Neutral, 1 Negative and 4 Positive

No false narratives or fake news; to read insights and analysis on the latest sector action, check out Pre-Open Brief

Never leave an investor uninformed!

Remember that overnight and pre-open actions’ futures and markets doesn’t necessarily translate into actual trading in today’s market session.

“I also hate to be so negative or contrarian but, this is a NO spin zone and truth is its product; I can always be WRONG but, I am mostly EARLY!”

My interpretation of the morning’s numbers is written to be informative; it’s built on what happened to make “it” happen today!

 

Friday’s night’s … RegMed Investors (RMi) Closing Bell: All I can sing: swing low, non-sweetening index chariot … https://www.regmedinvestors.com/articles/13932   

RegMed Investors (RMi) Research Note: Harvard Apparatus GT (OTCQB): No partner, No cash, NO runway, extensive liabilities and debts to past employee and university associations … https://www.regmedinvestors.com/articles/13812

 

Tuesday: The pre-open Dow futures are UP +1.33% or (+556 points), the S&P futures are UP +1.47% or (+85.75 points) and the Nasdaq futures are UP +1.57% or (+330 points)

  • Tuesday stock futures jumped after Monday’s Memorial Day market close
  • Tuesday European shares were upward after Monday positive moves
  • Asia-Pacific markets trade mixed again (Monday) as investors assess Trump’s tariff plans

 

Henry’omics: We need to more than consider the economic environment to comprehend the micro re “our” universe of cell and gene therapy companies

Friday: The Dow closed DOWN -256.02 points or -0.61%, the S&P closed DOWN -39.19 points or -0.67% while the Nasdaq closed DOWN -188.53 points or -1%

  • Stocks sold off on Friday after Trump’s threat to impose new tariffs on the EU and tech giant Apple.

Economic Data Docket:  couple …

  • April Durable Orders (month to month): -8.1% vs. 7.5% in November and May Consumer Confidence Survey: 89.4 vs. 86.0 in April
  • On Sunday, President Trump then said he had agreed to delay the 50% tariffs to July 9 following a call from EU Commission President Ursula von der Leyen.

 

Q2 – May – 8 negative and 9 positive closes

  • Q2 - April – 10 negative and 11 positive closes

Q1/25

  • March, 10 positive and 11 negative closes
  • February – 12 holiday, 11 negative and 7 positive closes
  • January - 2 holidays, 1 market close, 10 negative and 10 positive closes

 

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

Better part of valor to not lead any investor to temptation; yet again, I am passing on forecasting the daily indications as to expectation while the aftermarket blanked while the pre-open waits for the …  econs, it is still a mix of ups, downs and just uncertainty

Pre-open indications:

Alnylam Pharmaceuticals (ALNY) closed up +$0.06 with a positive aftermarket of +$1.46 or +0.50%

Blueprint Medicine (BPMC) closed up +$1.16 with a positive +2.50 or +2.46%

Ionis Pharmaceuticals (IONS) closed down -$0.28 with a negative aftermarket of -$0.59 or -1.79%

Intellia Therapeutics (NTLA) closed down -$0.30 with a pre-open positive +$0.12 or +1.31%

Moderna (MRNA) closed down -$0.46 with a positive pre-open +$0.59 or +2.55%

Vericel (VCEL) closed down -$0.46 with a neutral pre-open

 

The BOTTOM LINE: Maintaining, “When you think of wanting to decant (selling) or fill (buying) your portfolio carafe, always consider it, a glass half-full.”

May ‘25: understand the “flow” of bad market and economic karma…

  • 5/23 - Friday closed negative with 7 positive, 25 negative and 3 flats
  • 5/22 – Thursday closed positive with 19 positive, 14 negative and 2 flats
  • 5/21 – Wednesday closed negative with 3 positive, 30 negative and 2 flats
  • 5/20 – Tuesday closed positive with 23 positive, 9 negative and 3 flats
  • 5/19 - Monday closed positive with 23 positive, 12 negative and 1 flat
  • 5/16 - Friday closed positive with 29 positive, 3 negative and 3 flats
  • 5/15 – Thursday closed positive with 24 positive, 10 negative and 1 flat
  • 5/14 – Wednesday closed negative with 8 positive, 25 negative and 2 flats
  • 5/13 – Tuesday closed negative with 6 positive, 28 negative and 1 flat
  • 5/12 – Monday closed positive with 30 positive, 3 negative and 2 flats
  • 5/9 – Friday closed negative with 10 positive, 23 negative and 2 flats
  • 5/8 - Thursday closed positive with 25 positive, 8 negative and 2 flats
  • 5/7 – Wednesday closed positive with 16 positive, 15 negative and 4 flats
  • 5/6 – Tuesday closed negative with 2 positive, 31 negative and 2 flats
  • 5/5 - Monday closed negative with 9 positive, 23 negative and 3 flats
  • 5/2 – Friday closed positive with 24 positive, 8 negative and 3 flats
  • 5/1 – Thursday closed negative with 14 positive, 19 negative and 2 flats

 

As always, brace ourself for more volatility, economics and their down trending affect?

Welcome to my world of defining the “grey’ in our universe!

  • The sector is what it is, until it isn’t and even then, it doesn’t seem to be… as NOT much changes as the sector’s share pricing rides the waves of volatility, algorithms, electronic trading and short covering.
  • I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

 

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC): The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed in •