RegMed Investors’ (RMi) pre-open: Don’t hold your breath

June 4, 2025 8:12am

Remain patient, we will be seeing the defense play after multiple up sessions

More econs this week, with electronic trading on a leach while trade policy rumors resound

ADP data reflects a … Standstill … as private payrolls increased just 37,000 In May, below the 60,000 in April and the Dow Jones forecast for 110,000. It was the lowest monthly job total from the ADP count since March 2023. Regarding wages, annual pay grew at a 4.5% rate for those remaining in their positions and 7% for job changers, both little changed from April. It was the lowest monthly job total from the ADP count since March 2023.

Pre-open Indications: 1 Sell into Strength, 1 Negative and 3 Positive

No false narratives or fake news; to read insights and analysis on the latest sector action, check out Pre-Open Brief

Never leave an investor uninformed!

Remember that overnight and pre-open actions’ futures and markets doesn’t necessarily translate into actual trading in today’s market session.

“I also hate to be so negative or contrarian but, this is a NO spin zone and truth is its product; I can always be WRONG but, I am mostly EARLY!”

My interpretation of the morning’s numbers is written to be informative; it’s built on what happened to make “it” happen today!

Tuesday’s night’s … RegMed Investors (RMi) Closing Bell: who and what is driving gains … https://www.regmedinvestors.com/articles/13944

RegMed Investors (RMi) Research Note: Harvard Apparatus GT (OTCQB): No partner, No cash, NO runway, extensive liabilities and debts to past employee and university associations … https://www.regmedinvestors.com/articles/13812

Wednesday: The pre-open Dow futures are DOWN -0.04% or (-16 points), the S&P futures are DOWN -0.05% or (-3 points) and the Nasdaq futures are DOWN -0.14% or (-40 points)

• Stock futures dived post ADP data on Wednesday, 6/4,
• Europe markets rose as EU trade chief says U.S. talks ‘advancing in the right direction’
• Asia-Pacific markets advanced

Henry’omics: We need to more than consider the economic environment to comprehend the micro re “our” universe of cell and gene therapy companies

Tuesday: The Dow closed UP +214.16 points or +0.51%, the S&P closed UP +34.43 points or +0.58% while the Nasdaq closed UP +156.34 points or +0.81%

• Monday: The Dow closed UP +35.41points or +0.08%, the S&P closed UP +24.25 points or +0.41% while the Nasdaq closed UP +128.85 points or +0.67%
• Friday: The Dow closed UP +54.34 points or +0.13%, the S&P closed DOWN -0.48 points or -0.01% while the Nasdaq closed DOWN -62.11 points or -0.32%
• After Tuesday’s gains, the S&P 500 now sits less than 3% from its 52-week high. The Nasdaq, meanwhile, is less than 4% from its recent high, and the Dow is less than 6%.

Economic Data Docket:  ADP employment, Atlanta Fed President Bostic and Fed Gov Lisa Cook at Fed listens event, S&P final U.S. services PMI, ISM services and Fed Beige Book

Q2 – June – 2 positive closes

• May – 1 market holiday, 10 negative and 11 positive closes
• Q2 - April – 10 negative and 11 positive closes

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

Better part of valor to not lead any investor to temptation; yet again, I am passing on forecasting the daily indications as to expectation while the aftermarket blanked while the pre-open waits for the …  econs, it is still a mix of ups, downs and just uncertainty

Although:

Sell Into Strength: Beam Therapeutics (BEAM) closed up +$0.69 after Monday’s+$0.36 after Friday’s -$0.49 with a neutral pre-open

CRISPR Therapeutics (CRSP) closed up +$1.09 after Monday’s +0.66 after Friday’s -$0.49 with a positive +$0.25 or +0.66% pre-open

Moderna (MRNA) closed up +$0.76 after Monday’s +$0.49 after Friday’s -$0.37 with a positive +$0.28 or +1.01% pre-open

Agenus (AGEN) closed up +$0.30 after Monday’s +$0.70 after Friday’s +$0.23 with a positive +0.35 or +7% pre-open on news

Verve Therapeutics (VERV) closed up +$0.045 after Monday’s +0.345 after Friday’s -$0.15 with a negative -0.01 or -0.21%

The BOTTOM LINE: Not a clairvoyant, there are session that are just a flip-of-the-coin

Happening or an about to … treasury yields held relatively steady following the encouraging report on the U.S. job market.

• Higher Treasury yields make it more expensive for U.S. households and businesses to borrow money and can discourage investors from paying high prices for stocks and other investments.

Investors are waiting for updates on President Trump’s tariffs, including the imposition of 50% tariffs on imports of steel and aluminum due to take effect Wednesday.

With industries lobbying for him to expand that protection to products made from those materials, analysts say prices of many basic items will likely rise. <Yahoo Finance>

June ’25:

• 6/3 - Tuesday closed positive with 24 positive, 8 negative and 3 flats
• 6/2 - Monday closed positive with 25 positive, 7 negative and 3 flats

May ’25 last week: understand the “flow” of bad market and economic karma…

• 5/30 – Friday closed negative with 6 positive, 26 negative and 3 flats
• 5/29 –Thursday closed positive with 24 positive, 10 negative and 1 flat
• 5/28 -Wednesday closed negative with 7 positive, 26 negative and 2 flats
• 5/27 - Tuesday closed positive with 21 positive, 11 negative and 3 flats
• 5/26 - Monday. Market closed - holiday

Later this week, investors will receive the latest U.S. jobs-market update from the Labor Department. For weeks now, investors have been waiting and watching for an “ah-ha” moment in the economic data that would signal, in no uncertain terms, that the U.S. economy is heading for a recession, said Callie Cox, chief market strategist at Ritholtz Wealth Management. <MarketWatch>

Reiterating, “There are always some big ifs, especially given some of the headlines that could emanate after a past few months of news flatulence.

• As I also wrote, about June… “Get back-in and re-test the sector waters after May’s cell and gene therapy sector ‘s month alternations, nibble!  Some believe in a “June Swoon;” however, June will be no better or worse than any other month. Although, I consider the so-called summer rally after the peripatetic or wandering.”

As always, brace ourself for more volatility, economics and their down trending affect?

Welcome to my world of defining the “grey’ in our universe!

• The sector is what it is, until it isn’t and even then, it doesn’t seem to be… as NOT much changes as the sector’s share pricing rides the waves of volatility, algorithms, electronic trading and short covering.
• I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC): The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities.

I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.