RegMed Investors’ (RMi) pre-open: It ain’t over, still more econs

July 16, 2025 7:57am

June’s consumer inflation (CPI) report weighed on markets Tuesday; with another inflation reading today as June’s producer price index (PPI) ...

Breaking: June’s producer price index (PPI) reflected no change in wholesale prices for the month. Economists expected a 0.2% increase for PPI. Core wholesale inflation were subdued, final demand goods prices rose 0.3%, but were offset by a 0.1% fall in services. Within the goods category, tariff-sensitive communication equipment posted a gain of 0.8%. Core goods prices also rose 0.3%. Core goods prices also rose 0.3%. Energy prices rose 0.6% in June, while food prices increased 0.2%. Within the food category, chicken eggs tumbled 21.8%.

News: Prime Medicine (PRME +$0.04 or +0.93% to $4.33) Additional Funding of Up to $24 Million from the Cystic Fibrosis Foundation to Advance Prime Editing Treatments for Cystic Fibrosis. Voyager Therapeutics (VYGR +$0.02 or +0.81% to $3.10) continued the expansion of its Alzheimer’s disease (AD) franchise with the introduction of a wholly-owned program that modulates the expression of apolipoprotein E (APOE), the strongest genetic risk factor for AD.i

Remember market and sector’s share pricing up/downs are not always an exercise

Pre-open Signals: another weak aftermarket/pre-open, although 2 Positive Indications

Never leave an investor uninformed …

I say what others won’t, so you can do what others can’t!

If you’re interested in investing in the cell and gene therapy sector, it’s required to identify/postulate if “conditions” are attractive

Remember that overnight and pre-open actions’ futures and markets doesn’t necessarily translate into actual trading in today’s market session.

My interpretation of the morning’s numbers is written to be informative; it’s built on what happened to make “it” happen today!

Tuesday’s night’s … RegMed Investors (RMi) Closing Bell:  Wipe-out, a co-dependent of ebb and flow … https://www.regmedinvestors.com/articles/13998

RegMed Investors (RMi) Research Note: Harvard Apparatus GT (OTCQB): PONZI Scheme at its best or was convicted Bernie Madoff also resurrected … https://www.regmedinvestors.com/articles/13812

Tuesday: The pre-open Dow futures are UP +0.19% or (+82 points), the S&P futures are DOWN -0.06% or (-4 points) and the Nasdaq futures are DOWN -0.22% or (-50 point)

Stock futures are split, neg/pos on Wednesday, 7/16 waiting for yet another inflation data point

European stocks opened lower,

Asia-Pacific markets mostly fall after U.S.-Indonesia trade deal

Henry’omics: We need to more than consider the economic environment to comprehend the micro re “our” universe of cell and gene therapy companies

• Tuesday: The Dow closed DOWN -436.36 points or -0.98%, the S&P closed DOWN -24.80 points or -0.40% while the Nasdaq closed UP +37.47 points or +0.18%
• Monday: The Dow closed UP +81.93 points or +0.18%, the S&P closed UP +8.81 points or +0.14% while the Nasdaq closed UP +54.80 points or +0.27%
• Friday: The Dow closed DOWN -279.13 points or -0.63%, the S&P closed DOWN -20.71 points or -0.33% while the Nasdaq closed DOWN -45.14 points or -0.22%
• Last week, the S&P 500 dipped 0.3%, the Dow fell 1% and the Nasdaq dived -0.1%.

Economic Data Docket: Producer Price Index (PPI), Beige Book, Industrial Production, Capacity Utilization and a couple of Fed President Speeches

• Weekly mortgage demand plummeted 10%, as rates and economic concerns rose: the average contract interest rate for 30-year fixed-rate mortgages with conforming loan balances, $806,500 or less, increased to 6.82% from 6.77%. Applications for a mortgage to purchase a home dropped 12% for the week and were 13% higher than the same week 1-year ago. Applications to refinance a home loan dropped 7% for the week and were 25% higher than the same week 1-year ago.

More econs This Week, 7/14 to 7/18: PPI, another Initial Jobless Claims, Fed Beige book, Home Builder Confidence Index, Philadelphia Fed manufacturing survey, Retail sales, Housing Starts, Building Permits, and a few more contributing to inflation this week plus Fed Presidents speeches

Q3 – July – 1 market holiday, 7 positive and 3 negative closes

Q2  

• June – 1 market holiday, 1 neutral, 8 negative, and 11 positive closes
• May – 1 market holiday, 10 negative and 11 positive closes
• April – 10 negative and 11 positive closes

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

• Yet again, I am passing on forecasting the daily indications due to econs, algos and electronic trading, vacation … it is still a mix of ups, downs and just uncertainty

Although …

Alnylam Pharmaceuticals (ALNY) closed down -$4.63 after Monday’s +$0.81 with a positive +$6.68 or +2.15% pre-open

Beam Therapeutics (BEAM) closed down -$1.59 after Monday’s +$0.01, Friday’s -$0.87, Thursday’s +$0.57 and last Wednesday’s +$1.10 with a positive +$0.22 or +1.12% pre-open  

The BOTTOM LINE: July is here as econs stifle the sector and markets, and summer doldrums, tariff conflicts, vacations and selling before the earnings cycle to pay for the lobster rolls.

“I also hate to be so negative or contrarian but, this is a NO spin zone and truth is its product; I can always be WRONG but, I am mostly EARLY!”

Cell and gene therapy sector equities closed Friday negative after positive Thursday and Wednesday continued the run to the upside after Tuesday positive close after diving on Monday

• After last week popping multiple positive closes (Thursday, Wednesday, Tuesday and Monday) in this new month, July and Q.

To characterize July, to understand the “flow” of markets, the cell and gene therapy sector and economic karma…

• 7/15 - Tuesday closed negative with 3 positive, 29 negative and 3 flats
• 7/14 - Monday closed positive with 20 positive, 11 negative and 4 flats
• 7/11 – Friday closed negative with 5 positive, 28 negative and 2 flats
• 7/10 – Thursday closed positive with 19 positive, 14 negative and 2 flats
• 7/9 – Wednesday closed positive with 28 positive, 5 negative and 2 flats
• 7/8 - Tuesday closed positive with 22 positive, 10 negative and 3 flats
• 7/7 – Monday closed negative with 6 positive, 27 negative and 2 flats
• 7/4 – Friday was a market holiday
• 7/3 – Thursday closed positive with 23 positive, 6 negative and 6 flats
• 7/2 - Wednesday closed positive with 24 positive, 7 negative and 4 flats
• 7/1 – Tuesday closed positive with 21 positive, 11 negative and 3 flats
• 6/30 - Monday closed positive with 20 positive, 11 negative and 4 flats

Reiterating, “There are always some big ifs, especially given some of the headlines that could emanate after a past few months of news flatulence.

• Some believe in a “June Swoon;” however, June will be no better or worse than any other month. Although, I consider the so-called summer rally after the peripatetic or wandering.”

As always, I brace myself for more volatility, economics and their down trending affect?

Welcome to my world of defining the “grey’ in our universe!

• I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC): The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities.

 I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.