RegMed Investors’ (RMi) pre-open: volatility is still on the front burner

July 21, 2025 8:04am

As for this week, it doesn’t bring much in terms of economic data, but it does feature a busy earnings schedule

Despite the mixed reaction to econs, earnings; the season is off to a strong start.

Pre-open Signals: 5 Positive and 1 Negative Indications

Never leave an investor uninformed …

I say what others won’t, so you can do what others can’t!

Remember that overnight and pre-open actions’ futures and markets doesn’t necessarily translate into actual trading in today’s market session.

I post about “indication intelligence” devoting my time to collection and analysis of information to assist investors with insight into sector vulnerabilities and strengths. A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

Let’s get to the point, few adverbs and even fewer adjectives, no vacillating; I get right to the point, telling investors what has meaning and why news or indications matter.

Friday’s night’s … RegMed Investors (RMi) Closing Bell:  Another I told you so … https://www.regmedinvestors.com/articles/14004

RegMed Investors (RMi) Research Note: Harvard Apparatus GT (OTCQB): PONZI Scheme at its best or was convicted Bernie Madoff also resurrected … https://www.regmedinvestors.com/articles/13812

Monday: The pre-open Dow futures are UP +0.22% or (+99 points), the S&P futures are UP +0.22% or (+14 points) and the Nasdaq futures are UP +0.24% or (+56 point)

U.S. stock futures were “flitting” higher on Monday, 7/21

European were “steaming” lower as their session ran,

Asia-Pacific markets mostly rose then dived

Henry’omics: We need to more than consider the economic environment to comprehend the micro re “our” universe of cell and gene therapy companies

• Friday: The Dow closed DOWN -142.30 points or -0.323%, the S&P closed DOWN -0.547 points or -0.01% while the Nasdaq closed UP +10.01 points or +0.05%
• Thursday: The Dow closed UP +229.71 points or +0.52%, the S&P closed UP +33.66 points or +0.54% while the Nasdaq closed UP +153.78 points or +0.74%
• Wednesday: The Dow closed UP +231.49 points or +0.53%, the S&P closed UP +19.94 points or +0.32% while the Nasdaq closed UP +52.69 points or +0.26%
• Tuesday: The Dow closed DOWN -436.36 points or -0.98%, the S&P closed DOWN -24.80 points or -0.40% while the Nasdaq closed UP +37.47 points or +0.18%
• Monday: The Dow closed UP +81.93 points or +0.18%, the S&P closed UP +8.81 points or +0.14% while the Nasdaq closed UP +54.80 points or +0.27%
• Last week, the S&P 500 gained +0.06%, the Dow fell below -1% and the Nasdaq popped +1.5%.

Economic Data Docket: U.S. leading economic indicators for June – 10 a.m.

Q3 – July – 1 market holiday, 9 positive and 3 negative closes

Q2  

• June – 1 market holiday, 1 neutral, 8 negative, and 11 positive closes
• May – 1 market holiday, 10 negative and 11 positive closes
• April – 10 negative and 11 positive closes

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

• It is still a mix of ups, downs and just uncertainty …

Although:

Mesoblast (MESO) closed up +$3.28 with a positive +$0.08 or +0.51% pre-open – SELL into Strength

Beam Therapeutics (BEAM) closed up +$0.30 after Thursday’s +$0.38, Wednesday’s +$0.51 and Tuesday’s -$1.59 with a positive +$0.43 or +2.07% pre-open

Alnylam Pharmaceuticals (ALNY) closed down -$4.16+$1.88 after Wednesday’s +$11.50, Tuesday’s -$4.63 and Monday’s +$0.81 with a positive +$1.50 or +0.47% pre-open

CRISPR Therapeutics (CRSP) closed up +10.10.04 after Thursday’s -$0.05, Wednesday’s +$2.48, Tuesday’s -$3.69 and Monday’s -$0.38 with a positive +$2.08 or +3.19% pre-open

Moderna (MRNA) closed down -$0.94 after Thursday’s +$0.14, Wednesday’s +$0.52, Tuesday’s -$1.29 and Monday’s -$0.77 with a positive +$0.38 or +1.22% pre-open

Intellia Therapeutics (NTLA) closed up +$0.22 after Thursday’s -0.13 and Wednesday’s +0.53 with a positive +0.22 or +1.822% pre-open

The BOTTOM LINE: July is slowly coming to an end with 9 sessions left.

• After econs stifled the sector and markets, and summer doldrums, tariff conflicts, vacations and selling before the earnings cycle to pay for the lobster rolls.

Cell and gene therapy sector equities closed Friday negative after positive Thursday and Wednesday continued the run to the upside after Tuesday positive close after diving on Monday

• After last week popping multiple positive closes (Thursday, Wednesday, Tuesday and Monday) in this new month, July and Q.

“I also hate to be so negative or contrarian but, this is a NO spin zone and truth is its product; I can always be WRONG but, I am mostly EARLY!”

To characterize July, to understand the “flow” of markets, the cell and gene therapy sector and economic karma…

• 7/16 – Friday closed negative with 10 positive, 21 negative and 4 flats
• 7/17 – Thursday closed positive with 17 positive, 14 negative and 4 flats
• 7/16 - Wednesday closed positive with 24 positive, 5 negative and 6 flats
• 7/15 - Tuesday closed negative with 3 positive, 29 negative and 3 flats
• 7/14 - Monday closed positive with 20 positive, 11 negative and 4 flats

Last week:

• 7/11 – Friday closed negative with 5 positive, 28 negative and 2 flats
• 7/10 – Thursday closed positive with 19 positive, 14 negative and 2 flats
• 7/9 – Wednesday closed positive with 28 positive, 5 negative and 2 flats
• 7/8 - Tuesday closed positive with 22 positive, 10 negative and 3 flats
• 7/7 – Monday closed negative with 6 positive, 27 negative and 2 flats

Reiterating, “There are always some big ifs, especially given some of the headlines that could emanate after a past few months of news flatulence.

• Some believe in a “June Swoon;” however, June will be no better or worse than any other month. Although, I consider the so-called summer rally after the peripatetic or wandering.”

As always, I brace myself for more volatility, economics and their down trending affect?

Welcome to my world of defining the “grey’ in our universe!

• I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC): The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities.

 I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.