July 25, 2025 8:01am

Ending the week weak, splitting early to beat the heat

Thursday, the Russell 2000 was down -0.7%; although remaining up 1.3% for the week

Pre-open Signals: IF (it’s Friday)

News: Ionis Pharmaceuticals (IONS +$0.23 or +0.55% to $42.38 pre-open) and Sobi® today announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency has adopted a positive opinion of TRYNGOLZA® (olezarsen) as an adjunct to diet in adult patients for the treatment of genetically confirmed familial chylomicronemia syndrome (FCS). The positive opinion is now referred to the European Commission (EC) for an approval decision, which is expected by Q4/25.

Never leave an investor uninformed … I try to rationalize the whys of inclines or declines in share pricing as lately it seems no news is good news

I say what others won’t, so you can do what others can’t!

Remember that overnight and pre-open actions’ futures and markets doesn’t necessarily translate into actual trading in today’s market session.

Let’s get to the point, few adverbs and even fewer adjectives, no vacillating; I get right to the point, telling investors what has meaning and why news or indications matter.

 

Thursday’s night’s … RegMed Investors (RMi) Closing Bell: Econs flash their “six” with expectation and in anticipation … https://www.regmedinvestors.com/articles/14012

RegMed Investors (RMi) Research Note: Harvard Apparatus GT (OTCQB): Sustaining a Loser … https://www.regmedinvestors.com/articles/13812

 

Friday: The pre-open Dow futures are UP +0.05% or (+23 points), the S&P futures are UP +0.07% or (+4 points) and the Nasdaq futures are DOWN -0.04% or (-8.75 point)

  • Stock futures crawled mixed on Friday, 7/25,
  • European markets were crashing,
  • Asia-Pacific markets slipped and fell.

 

Henry’omics: We need to more than consider the economic environment to comprehend the micro re “our” universe of cell and gene therapy companies

  • Thursday: The Dow closed DOWN -316.20 points or -0.70%, the S&P closed UP +4.44 points or +0.07% while the Nasdaq closed UP +37.94 points or +0.18%
  • Wednesday: The Dow closed UP +507.85 points or +1.14%, the S&P closed UP +49.33 points or +0.78% while the Nasdaq closed UP +127.33 points or +0.61%
  • Tuesday: The Dow closed UP +179.37 points or +0.40%, the S&P closed UP +4.02 points or +0.06% while the Nasdaq closed DOWN – 81.49 points or -0.39%
  • Monday: The Dow closed DOWN -19.12 points or -0.04%, the S&P closed UP +8.81 points or +0.14% while the Nasdaq closed UP +78.52 points or +0.38%

Economic Data Docket: Durable-goods orders and Durable-goods minus transportation

 

Q3 – July – 1 market holiday, 13 positive and 5 negative closes

Q2  

  • June – 1 market holiday, 1 neutral, 8 negative, and 11 positive closes
  • May – 1 market holiday, 10 negative and 11 positive closes
  • April – 10 negative and 11 positive closes

 

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

  • I’ll pass; it is Friday, an escape in the making of ups, downs and just plain uncertainty

 

The BOTTOM LINE: I … STILL …feel RED flags are flying and the firing range is open!

July is slowly coming to an end with 5 (including today) sessions left.

  • After econs stifled the sector and markets, and summer doldrums, tariff conflicts, vacations and selling before the earnings cycle to pay for the lobster rolls.

 

Earnings are a’comin: 7/29, Tuesday = uniQure NV (QURE), 7/30, Wednesday = MiMedx (MDXG), 7/31, Thursday = Alnylam Pharmaceuticals (ALNY), Vericel (VCERL), 8/1 = Ionis Pharmaceuticals (IONS), Moderna (MRNA) and 8/5, Tuesday = AxoGen (AXGN)

 

Cell and gene therapy sector equities closed negative on Thursday after Wednesday, Tuesday and Monday positive closes …

  • After Friday’s negative after positive Thursday and Wednesday continued the run to the upside after Tuesday positive close after diving on Monday
  • After last week popping multiple positive closes (Thursday, Wednesday, Tuesday and Monday) in this new month, July and Q.

“I also hate to be so negative or contrarian but, this is a NO spin zone and truth is its product; I can always be WRONG but, I am mostly EARLY!”

To characterize July, to understand the “flow” of markets, the cell and gene therapy sector and economic karma…

  • 7/24 – Thursday closed negative with 7 positive, 25 negative and 3 flats
  • 7/23 – Wednesday closed positive with 30 positive, 1 negative and 4 flats
  • 7/22 – Tuesday closed positive with 19 positive, 10 negative and 6 flats
  • 7/21 – Monday closed positive with 17 positive, 14 negative and 4 flats

Last week:

  • 7/18 – Friday closed negative with 10 positive, 21 negative and 4 flats
  • 7/17 – Thursday closed positive with 17 positive, 14 negative and 4 flats
  • 7/16 - Wednesday closed positive with 24 positive, 5 negative and 6 flats
  • 7/15 - Tuesday closed negative with 3 positive, 29 negative and 3 flats
  • 7/14 - Monday closed positive with 20 positive, 11 negative and 4 flats

The previous week:

  • 7/11 – Friday closed negative with 5 positive, 28 negative and 2 flats
  • 7/10 – Thursday closed positive with 19 positive, 14 negative and 2 flats
  • 7/9 – Wednesday closed positive with 28 positive, 5 negative and 2 flats
  • 7/8 - Tuesday closed positive with 22 positive, 10 negative and 3 flats
  • 7/7 – Monday closed negative with 6 positive, 27 negative and 2 flats

Reiterating, “There are always some big ifs, especially given some of the headlines that could emanate after a past few months of news flatulence.

  • Some believe in a “June Swoon;” however, July has been better than the previous months. Although, I consider the so-called summer rally after the peripatetic or wandering.”

As always, I brace myself for more volatility, economics and their down trending affect?

Welcome to my world of defining the “grey’ in our universe!

  • I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

 

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC): The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities.

 I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.