RegMed Investors’ (RMi) pre-open: hold the line

August 18, 2025 7:50am

That is, the Advance/Decline (A/D) line after 4 successive positive closes

Why the market and sector been experiencing the ups lately, so far in August? It was the sectors grappling with being oversold, not the usual missed earnings beat and consensus scores but advancing quantifiable trials

What's more interesting is a few M&A’s, some solid runways and a few follow-on offerings and in multiple cases positive clinical guidance despite all the whispering about the FDA, drug tariffs and the FED, notwithstanding the potential of “uncle algo and his electronic dwarfs” now gathering for profit taking

Never leave an investor uninformed … I say what others won’t, so you can do what others can’t!

Remember that overnight and pre-open actions’ futures and markets doesn’t necessarily translate into actual trading in today’s market session.

There are buying opportunities and sell signals, but many names are likely to reverse direction after the open …

Pre-open (my) Signals: 5 Negative Indications

My interpretation of the morning’s numbers is written to be informative; it’s built on what happened to make “it” happen today!

Friday’s night’s … RegMed Investors (RMi) Closing Bell: My expectation thesis became a component of reality … https://www.regmedinvestors.com/articles/14066

RegMed Investors (RMi) Research Note: Harvard Apparatus GT (OTCQB): Just another wrinkle – Q2/25’s 10-Q – liabilities exceed cash position … https://www.regmedinvestors.com/articles/13812

Monday: The pre-open Dow futures are DOWN -0.08% or (-35 points), the S&P futures are DOWN -0.15% or (-9.75 points) and the Nasdaq futures are DOWN -0.22% or (-52.75 point)

• Stock futures traded lower Monday 8/18
• European markets were lower,
• Asia-Pacific markets closed mostly higher.

Henry’omics: We need to more than consider the economic environment to comprehend the micro re “our” universe of cell and gene therapy companies

• Friday: The Dow closed UP +34.85 points or +0.08%, the S&P closed DOWN -18.74 points or -0.29% while the Nasdaq closed DOWN -87.693 points or -0.40%
• Thursday: The Dow closed DOWN -11.01 points or -0.02%, the S&P closed UP +1.96 points or +0.03% while the Nasdaq closed DOWN -2.47 points or -0.01%
• Wednesday: The Dow closed UP +463.66 points or +1.04%, the S&P closed UP +20.82 points or +0.32% while the Nasdaq closed UP +31.236 points or +0.14%
• Tuesday: The Dow closed UP +483.52 points or +1.10%, the S&P closed UP +72.31 points or +1.13% while the Nasdaq closed UP +296.50 points or +1.39%
• Monday: The Dow closed DOWN -200.52 points or -0.45%, the S&P closed DOWN -16 points or -0.25% while the Nasdaq closed DOWN -64.62 points or -0.30%
• Last week, the S&P 500 was up +0.9%. the Nasdaq is up +0.8% and the Dow +1.7%.
• The previous week, the S&P 500 has gained 2.5%, the Nasdaq has added +3.9% and the Dow has advanced 1.4%.

Economic Data Docket: he National Association of Home Builders’ August housing market index at 10 a.m. ET. July’s reading rose to 33, but mortgage rates north of 6% have kept optimism in check.

• Investors will be looking for any cracks in builder confidence that might foreshadow softness in starts and permits later in the week.

Q3 – August - 6 negative and 5 positive closes

•             July – 1 market holiday, 13 positive and 9 negative closes

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

•  The usual ups, downs and just plain uncertainty

Although … my thoughts

Alnylam Pharmaceuticals (ALNY closed up +$6.18 after Thursday’s +$10.21, Wednesday’s +$2.59, Tuesday’s -$5.07 and Monday’s -$3.93 with a positive +$0.99 pre-open – SELL into Strength

IQVIA Holdings (IQV closed up +$1.69 after Thursday’s -$0.83, Wednesday’s +$4.27, Tuesday’s +$5.90 and Monday’s +$0.28 with a negative -$0.09 pre-open

Sarepta Therapeutics (SRPT +$1.51 with a positive +$0.09 pre-open – SELL into Strength

Precigen (PGEN closed up+$1.09 after FDA approval with a negative -$0.06 pre-open

CRISPR Therapeutics (CRSP closed up +$0.91 after Thursday’s +$1.55 with a negative -$0.43 pre-open

The BOTTOM LINE: Market ups, econs … the causes and effect …

After rate fears of a suspect or even a measly Fed rate cut, markets ended the week largely unfazed by hotter wholesale inflation print.

• The fresh data now puts the Fed, which targets 2% inflation, in a precarious position as tensions between its dual mandate of price stability and maximum employment begin to surface.

Massive downward revisions in July's jobs report last week fueled concerns that the labor market is softening too quickly, strengthening the case for rate cuts. But the hotter-than-anticipated inflation data could suggest the need for more restraint.

• As of Friday afternoon, markets continued to price in about an 85% probability that the central bank will cut rates in September, according to the latest CME FedWatch Tool. Fed Chair Powell's Jackson Hole speech this week could give hints on the Fed's next policy move??

August: understand the “flow” …

• 8/15 – Friday closed positive with 25 positive, 9 negative and 1 flat
• 8/14 – Thursday closed positive with 18 positive, 17 negative and 0 flat
• 8/13 – Wednesday closed positive with 32 positive, 2 negative and 1 flat
• 8/12 - Tuesday closed positive with 28 positive, 6 negative and 1 flat
• 8/11 – Monday closed negative with 10 positive, 25 negative and 0 flat
• 8/8 – Friday closed negative with 11 positive, 23 negative and 1 flat
• 8/7 – Thursday closed negative with 9 positive, 24 negative and 2 flats
• 8/6 – Wednesday closed negative with 11 positive, 22 negative and 2 flats
• 8/5 – Tuesday closed negative with 15 positive, 19 negative and 1 flat
• 8/4 – Monday closed positive with 27 positive, 8 negative and 0 flats
• 8/1 – Friday closed negative with 9 positive, 20 negative and 6 flats

Earnings are still the highlight of the week: Meeting earnings expectation and/or missing consensus will deem share pricing outcomes.

• Earnings:  4 net incomes and 25 net losses of 29 releases to date

I also hate to be so negative or contrarian but, this is a NO spin zone and truth is its product; I can always be WRONG but, I am mostly EARLY!”

Reiterating, “There are always some big ifs, especially given some of the headlines that could emanate after a past few months of news flatulence.

• As always, I brace myself for earnings associated with share pricing volatility, some economics and tariff developments and their effects?

Welcome to my world of defining the “grey’ in our universe!

• I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC): The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities.

 I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.