RegMed Investors’ (RMi) pre-open: Anticipating a pop or am I dreaming?

August 21, 2025 7:57am

The recent selling binge followed a buying spree tailed by a sell-off begets some “ascensions” rewarding post earnings releases with better clinical advances and runways; although some lower highs.

News: Sarepta Therapeutics (SRPT -$0.81 or -3.94% to $19.77) has entered into negotiated exchange agreements with a limited number of holders of its 1.25% convertible senior notes due 2027. Pursuant to the exchange agreements, the Company will exchange approximately $700.0 M in aggregate principal amount of the Existing Convertible Notes for approximately $602 M in aggregate principal amount of new 4.875% convertible senior notes due 2030 (up to approximately 6.7 M shares of its common stock and approximately $123.3 M in cash. Additionally, it entered into a privately negotiated subscription agreement with J. Wood Capital Advisors LLC for the private placement of up to approximately 1.4 M shares of stock.

BREAKING: Initial unemployment benefit filings saw a bump last week through layoffs still appear to be limited. Jobless claims totaled 235,000 for the week ending Aug. 16, up 11,000 from the prior period and higher than the consensus estimate for 225,000. The Philadelphia Fed’s manufacturing index for August posted an unexpectedly weak reading of -0.3, down from 15.9 the prior month and below the estimate for 7.0.

Never leave an investor uninformed … I say what others won’t, so you can do what others can’t!

Remember that overnight and pre-open actions’ futures and markets doesn’t necessarily translate into actual trading in today’s market session.

There are buying opportunities and sell signals, but many names are likely to reverse direction after the open …

Pre-open (my) Signals: 2 Negative and 4 Positive Indications

My interpretation of the morning’s numbers is written to be informative; it’s built on what happened to make “it” happen today!

Wednesday’s night’s … RegMed Investors (RMi) Closing Bell: It was not a surprise … https://www.regmedinvestors.com/articles/14071

RegMed Investors (RMi) Research Note: Harvard Apparatus GT (OTCQB): Just another wrinkle – Q2/25’s 10-Q – liabilities exceed cash position … https://www.regmedinvestors.com/articles/13812

Thursday: The pre-open Dow futures are DOWN -0.32% or (-142 points), the S&P futures are DOWN -0.19% or (-12 points) and the Nasdaq futures are DOWN -0.13% or (-30 point)

• Stock futures inched down ward on Thursday, 8/21
• European markets dived,
• Asia-Pacific markets mostly rose.

Henry’omics: We need to consider the state of the closes  to comprehend “our” the effect to our universe of cell and gene therapy companies

• Wednesday: The Dow closed UP +16.04 points or +0.04%, the S&P closed DOWN -15.59 points or -0.24% while the Nasdaq closed DOWN -142.095 points or -0.67%
• Tuesday: The Dow closed UP +10.45 points or +0.02%, the S&P closed DOWN -37.78 points or -0.59% while the Nasdaq closed DOWN – 314.82 points or -1.46%
• Monday: The Dow closed DOWN -34.30 points or -0.08%, the S&P closed DOWN -0.65 points or -0.01% while the Nasdaq closed UP +6.797 points or +0.03%
• Last week, the S&P 500 was up +0.9%. the Nasdaq is up +0.8% and the Dow +1.7%
• The previous week, the S&P 500 has gained 2.5%, the Nasdaq has added +3.9% and the Dow has advanced 1.4%.

Economic Data Docket: Initial jobless claims, Philadelphia Fed manufacturing survey - Aug., S&P flash U.S. services PMI - Aug., S&P flash U.S. manufacturing PMI -Aug., Existing home sales – July and U.S. leading economic indicators.                                  

Q3 – August - 7 negative and 6 positive closes

•             July – 1 market holiday, 13 positive and 9 negative closes

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

• I’ll pass; …. an escape from this week’s econs and more earnings releases, and the usual ups, downs and just plain uncertainty

Although …

CRISPR Therapeutics (CRSP) closed down -$1.09 after Tuesday’s -$3.43 and Monday’s -$2.14 with a positive +$0.23 or +0.43% pre-open

Beam Therapeutics (BEAM) closed down -$0.29 after Tuesday’s -$0.75 and Monday’s -$0.72 with a positive +$0.35 or +2.18% pre-open

Moderna (MRNA) closed down -$1.02 with a positive +$0.02 or +0.07% pre-open

Mesoblast (MESO) closed down -$0.13 after Tuesday’s -$0.79 and Monday’s -$0.32 with a positive +$0.02 or +0.07% pre-open

Sarepta Therapeutics (SRPT) closed up +$0.40 with a negative -$0.81 or -3.94% pre-open

Lenz Therapeutics (LENZ) closed up +$0.93 after Tuesday’s -$1.16 after Monday’s +$0.92 with a negative -$0.14 or -0.36% pre-open

The BOTTOM LINE: A new session today, Thursday waiting for sentiment’s tone

• Wednesday, the stock market had another mixed session, with the Nasdaq and S&P 500 falling but closing well off session lows.

As sector” leaders” sold off in recent days, investors should be “picking-up sticks i.e., shares” and scaling out to some extent.

• If you do nothing, the risk is that you'll gain however if a “falling knife” you will lose to gain in the future.
• But, by selling some closer to the top, it's easier to exit, or most times you can get away with holding-on through a sell-off.
• Shares always seem to bounce back, if one waits long enough.

And I do NOT see huge, crippling losses in the near future.

August: understand the “flow” …

• 8/20 - Wednesday closed negative with 14 positive, 19 negative and 2 flats
• 8/19 - Tuesday closed negative with 5 positive, 28 negative and 2 flats
• 8/18 -Monday closed neutral with 18 positive, 17 negative and 0 flat
• 8/15 – Friday closed positive with 25 positive, 9 negative and 1 flat
• 8/14 – Thursday closed positive with 18 positive, 17 negative and 0 flat
• 8/13 – Wednesday closed positive with 32 positive, 2 negative and 1 flat
• 8/12 - Tuesday closed positive with 28 positive, 6 negative and 1 flat
• 8/11 – Monday closed negative with 10 positive, 25 negative and 0 flat
• 8/8 – Friday closed negative with 11 positive, 23 negative and 1 flat
• 8/7 – Thursday closed negative with 9 positive, 24 negative and 2 flats
• 8/6 – Wednesday closed negative with 11 positive, 22 negative and 2 flats
• 8/5 – Tuesday closed negative with 15 positive, 19 negative and 1 flat
• 8/4 – Monday closed positive with 27 positive, 8 negative and 0 flats
• 8/1 – Friday closed negative with 9 positive, 20 negative and 6 flats

A problem in the week, “Fed minutes from the late July meeting show policymakers divided between inflation and labor market concerns as tariffs complicate the central bank's job. Fed chief Jerome Powell will give his final Jackson Hole speech on Friday morning.” <IBD>

Earnings are still the highlight of the week: Meeting earnings expectation and/or missing consensus will deem share pricing outcomes.

• Earnings:  4 net incomes and 25 net losses of 29 releases to date

I also hate to be so negative or contrarian but, this is a NO spin zone and truth is its product; I can always be WRONG but, I am mostly EARLY!”

Welcome to my world of defining the “grey’ in our universe!

• I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC): The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities.

 I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.