RegMed Investors’ (RMi) pre-open: Clarity on the interest rate outlook

August 22, 2025 7:49am

Could determine the direction of the near-term outlook for the stock market that’s come under pressure

“It’s always darkest before the pitch dark”

There are buying opportunities and sell signals, but many names are likely to reverse direction after the open …

Never leave an investor uninformed … I say what others won’t, so you can do what others can’t!

Remember that overnight and pre-open actions’ futures and markets doesn’t necessarily translate into actual trading in today’s market session.

The sector is what it is, until it isn’t and even then, it doesn’t seem to be …

Pre-open (my) Signals: 2 Negative, 2 Positive and a lot of No Indications

My interpretation of the morning’s numbers is written to be informative; it’s built on what happened to make “it” happen today!

Thursday’s night’s … RegMed Investors (RMi) Closing Bell: Waiting for Jerome … Like “Waiting for Godot”, a tragic comedy plays-out and rate cuts also don’t arrive … https://www.regmedinvestors.com/articles/14073

RegMed Investors (RMi) Research Note: Harvard Apparatus GT (OTCQB): Just another wrinkle – Q2/25’s 10-Q – liabilities exceed cash position … https://www.regmedinvestors.com/articles/13812

Friday: The pre-open Dow futures are UP +0.28% or (+125 points), the S&P futures are UP +0.17% or (+11 points) and the Nasdaq futures are UP +0.11% or (+25 point)

• U.S. stock futures rose slightly Friday preparing for the Powell speech,  
• European markets traded higher,
• Asia-Pacific markets traded mixed

Henry’omics: We need to more than consider the economic environment to comprehend the micro re “our” universe of cell and gene therapy companies

• Thursday: The Dow closed DOWN -152.81 points or -0.34%, the S&P closed DOWN -25.61 points or -0.40% while the Nasdaq closed DOWN -72.545 points or -0.34%
• Wednesday: The Dow closed UP +16.04 points or +0.04%, the S&P closed DOWN -15.59 points or -0.24% while the Nasdaq closed DOWN -142.095 points or -0.67%
• Tuesday: The Dow closed UP +10.45 points or +0.02%, the S&P closed DOWN -37.78 points or -0.59% while the Nasdaq closed DOWN – 314.82 points or -1.46%
• Monday: The Dow closed DOWN -34.30 points or -0.08%, the S&P closed DOWN -0.65 points or -0.01% while the Nasdaq closed UP +6.797 points or +0.03%
• Last week, the S&P 500 was up +0.9%. the Nasdaq is up +0.8% and the Dow +1.7%
• The previous week, the S&P 500 has gained 2.5%, the Nasdaq has added +3.9% and the Dow has advanced 1.4%.

Economic Data Docket: Fed Chair Jerome Powell speaks from Jackson Hole                                          

Q3 – August - 7 negative and 7 positive closes

•             July – 1 market holiday, 13 positive and 9 negative closes

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

• I’ll pass; …. an escape from this week’s econs and more earnings releases, and the usual ups, downs and just plain uncertainty

Although:

Lenz Therapeutics (LENZ0 closed up +$1.31 after Wednesday’s +$0.93 after Tuesday’s -$1.16 after Monday’s +$0.92 with a positive +$0.15 or +0.38% pre-open

Sarepta Therapeutics (SRPT) closed down -$0.52 after Wednesday’s +$0.40 after Tuesday’s -$0.81 after Monday’s -$0.82 with a negative -$0.20 or -1% pre-open

Precigen (PGEN0 closed up +$0.43 with a positive +$0.09 or +2.47% pre-open

Alnylam Pharmaceuticals (ALNY) closed up +$9.24 with a negative -$1.13 or -0.24% pre-open

The BOTTOM LINE: Powell's speech has investors on edge. His remarks are set to not only shake up rate-cut bets but also shape monetary policy for years to come.

• More signs that a rate cut may not be imminent piled up.
• Minutes from the Federal Reserve's last meeting showed that the two officials who dissented from the decision to hold rates steady in July were largely alone in their opinion.
• The minutes’ also indicated inflation was more of a concern for officials than labor market weakness.
• Finally, two policymakers, Jeffrey Schmid and Beth Hammack, expressed wariness over a September rate cut on Thursday.

As I wrote in the title, “It’s always darkest before the pitch dark”

Scaling your positions to some extent.

• If you do nothing, the risk is that you'll gain however, if a “falling knife” you will lose to gain in the future.
• But, by selling some closer to the top, it's easier to exit, or most times you can get away with holding-on through a sell-off.
• Shares always seem to bounce back, if one … waits long enough.

And I do NOT see huge, crippling losses in the near future.

August: understand the “flow” …

• 8/21 – Thursday closed positive with 22 positive, 12 negative and 1 flat
• 8/20 - Wednesday closed negative with 14 positive, 19 negative and 2 flats
• 8/19 - Tuesday closed negative with 5 positive, 28 negative and 2 flats
• 8/18 -Monday closed neutral with 18 positive, 17 negative and 0 flat
• 8/15 – Friday closed positive with 25 positive, 9 negative and 1 flat
• 8/14 – Thursday closed positive with 18 positive, 17 negative and 0 flat
• 8/13 – Wednesday closed positive with 32 positive, 2 negative and 1 flat
• 8/12 - Tuesday closed positive with 28 positive, 6 negative and 1 flat
• 8/11 – Monday closed negative with 10 positive, 25 negative and 0 flat
• 8/8 – Friday closed negative with 11 positive, 23 negative and 1 flat
• 8/7 – Thursday closed negative with 9 positive, 24 negative and 2 flats
• 8/6 – Wednesday closed negative with 11 positive, 22 negative and 2 flats
• 8/5 – Tuesday closed negative with 15 positive, 19 negative and 1 flat
• 8/4 – Monday closed positive with 27 positive, 8 negative and 0 flats
• 8/1 – Friday closed negative with 9 positive, 20 negative and 6 flats

A problem in the week, “Fed minutes from the late July meeting show policymakers divided between inflation and labor market concerns as tariffs complicate the central bank's job.

• Fed chief Jerome Powell will give his final Jackson Hole speech on this morning.” 

Earnings are a highlight: Meeting earnings expectation and/or missing consensus will deem share pricing outcomes.

• Earnings:  4 net incomes and 25 net losses of 29 releases to date

I also hate to be so negative or contrarian but, this is a NO spin zone and truth is its product; I can always be WRONG but, I am mostly EARLY!”

Reiterating, “There are always some big ifs, especially given some of the headlines that could emanate after a past few months of news flatulence.

• As always, I brace myself for earnings associated with share pricing volatility, some economics and tariff developments and their effects?

Welcome to my world of defining the “grey’ in our universe!

• I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC): The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities.

 I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.