RegMed Investors’ (RMi) pre-open: Are “they” coming for us i.e., portfolio?

August 26, 2025 7:52am

Increasing cash positions until September advance hedge and institution rebalancing and rotations

I'll be by the pool ... trying to escape market forces!

Even as I see some aftermarket green, I expect more sentiment selling as we get closer to August’s month end and to the Labor Day holiday

Never leave an investor uninformed … I say what others won’t, so you can do what others can’t!

Remember that overnight and pre-open actions’ futures and markets doesn’t necessarily translate into actual trading in today’s market session.

Pre-open (my) Signals: 5 Positive Indications

The sector is what it is, until it isn’t and even then, it doesn’t seem to be …

My interpretation of the morning’s numbers is written to be informative; it’s built on what happened to make “it” happen today!

Monday’s night’s … RegMed Investors (RMi):  Sector dives as Labor Day weekend is on its way … https://www.regmedinvestors.com/articles/14077

RegMed Investors (RMi) Research Note: Harvard Apparatus GT (OTCQB): Just another wrinkle – Q2/25’s 10-Q – liabilities exceed cash position … https://www.regmedinvestors.com/articles/13812

Tuesday: The pre-open Dow futures are DOWN -0.12% or (-55 points), the S&P futures are DOWN -0.10% or (-6 points) and the Nasdaq futures are DOWN -0.10% or (-24 point)

• U.S. stock futures were lower early Tuesday, 8/26
• European stock markets opened sharply lower,
• Asia Pacific markets mostly fall

Henry’omics: We need to more than consider the economic environment to comprehend the micro re “our” universe of cell and gene therapy companies

• Monday: The Dow closed DOWN -349.27 points or -0.77%, the S&P closed DOWN -27.59 points or -0.43% while the Nasdaq closed DOWN -47.243 points or -0.22%
• Friday: The Dow closed UP +846.24 points or +1.89%, the S&P closed UP +96.75 points or +1.52% while the Nasdaq closed UP +396.223 points or +1.88%

Economic Data Docket: FHFA house price index, month over month, June (-0.2% prior); S&P CoreLogic Case-Shiller 20-City, year over year, non-seasonally adjusted (+2.8% prior); Conference Board Consumer Confidence, August (96.4 expected, 97.2 prior); Richmond Fed manufacturing index, August (-20 prior)                      

Q3 – August - 8 negative and 8 positive closes

•             July – 1 market holiday, 13 positive and 9 negative closes

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

• I’ll pass; …. an escape from this week’s econs and the usual ups, downs and just plain uncertainty

Although:

• BioNTech SE (BNTX) closed down -$5.81 with a positive +$0.24 or +0.23% pre-open
• CRISPR Therapeutics (CRSP) closed down -$0.19 after Friday’s +$1.50 with a positive +$0.42 or +0.78% pre-open
• Sarepta Therapeutics (SRPT) closed down -$2.16 with a positive +$0.23 or +1.27% pre-open
• Moderna (MRNA) closed down -$1.77 after Friday’s +$0.90 with a positive +$0.13 or +0.51% pre-open
• Beam Therapeutics (BEAM) closed down -$0.20 after Friday’s +$0.63 with a positive +$0.12 or 0.73% pre-open

The BOTTOM LINE: A lot of green in Monday’s aftermarket while downside risks are on the table … as September’s fund with rebalancing and forthcoming rotations.

• I expect some sentiment selling as we get closer to August’s month end and to Labor Day

Putting to the test on the coming Friday with the release of the Personal Consumption Expenditures (PCE) index, the Fed's preferred inflation measure.

• Expect core PCE inflation to peak slightly above 3% by the end of the year. With inflation drifting in the wrong direction and the labor market losing momentum, the Fed faces difficult trade-offs in balancing its dual mandate."

August: understand the “flow” …

• 8/25 – Monday closed negative with 4 positive, 29 negative and 2 flats

Last week:

• 8/22 – Friday closed positive with 30 positive, 4 negative and 1 flat
• 8/21 – Thursday closed positive with 22 positive, 12 negative and 1 flat
• 8/20 - Wednesday closed negative with 14 positive, 19 negative and 2 flats
• 8/19 - Tuesday closed negative with 5 positive, 28 negative and 2 flats
• 8/18 - Monday closed positive with 18 positive, 17 negative and 0 flat

Earnings:  A few left, so far ... 4 net incomes and 25 net losses of 29 releases to date

I also hate to be so negative or contrarian but, this is a NO spin zone and truth is its product; I can always be WRONG but, I am mostly EARLY!”

Welcome to my world of defining the “grey’ in our universe!

• I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC): The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities.

 I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.