August 27, 2025 6:37am
While U.S. markets march higher, the VIX, sometimes called the “fear gauge” settled Tuesday (8/26) at 14.62 closer to the year-lows (12.70) after the highest close at 52.33 (4/8/25)
Even as I see some aftermarket green, I expect more sentiment selling as we get closer to August’s month end and to the Labor Day holiday
Never leave an investor uninformed … I say what others won’t, so you can do what others can’t!
Remember that overnight and pre-open actions’ futures and markets doesn’t necessarily translate into actual trading in today’s market session.
Pre-open (my) Signals: 5 Positive and 2 Negative Indications
The sector is what it is, until it isn’t and even then, it doesn’t seem to be …
My interpretation of the morning’s numbers is written to be informative; it’s built on what happened to make “it” happen today!
Tuesday’s night’s … RegMed Investors (RMi): Sector identified by pockets of green and red … https://www.regmedinvestors.com/articles/14079
RegMed Investors (RMi) Research Note: Harvard Apparatus GT (OTCQB): Just another wrinkle – Q2/25’s 10-Q – liabilities exceed cash position … https://www.regmedinvestors.com/articles/13812
Wednesday: The pre-open Dow futures are UP +0.05% or (+22 points), the S&P futures are UP +0.03% or (+2 points) and the Nasdaq futures are UP +0.02% or (+4 point)
- Stock futures were basically flat and positive Wednesday, 8/27
- European markets shed early gains and traded lower,
- Asia-Pacific markets trade mixed.
Henry’omics: We need to more than consider the economic environment to comprehend the micro re “our” universe of cell and gene therapy companies
- Tuesday: The Dow closed UP +135.60 points or +0.30%, the S&P closed UP +26.62 points or +0.41% while the Nasdaq closed UP +94.978 points or +0.44%
- Monday: The Dow closed DOWN -349.27 points or -0.77%, the S&P closed DOWN -27.59 points or -0.43% while the Nasdaq closed DOWN -47.243 points or -0.22%
Economic Data Docket: MBA Mortgage Applications, week ending Aug. 22 (-1.4% prior)
Q3 – August - 9 negative and 9 positive closes
• July – 1 market holiday, 13 positive and 9 negative closes
Companies in my headlights – It’s your decision; I provide ideas and context
I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths. A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.
- I’ll pass; …. an escape from this week’s econs and more earnings releases, and the usual ups, downs and just plain uncertainty
Although:
BioNTech SE (BNTX) closed down -$0.28 after Monday’s -$5.81 with a positive +$0.77 or +0.73% pre-open
CRISPR Therapeutics (CRSP) closed up +$0.75 after Monday’s -$0.19 after Friday’s +$1.50 with a positive +$0.57 or +1.04% pre-open
Sarepta Therapeutics (SRPT) closed up +0.10 after Monday’s -$2.16 with a positive +$0.07 or +0.38% pre-open
Moderna (MRNA) closed down -$0.62 after Monday’s -$1.77 after Friday’s +$0.90 with a positive +$0.15 or +0.61% pre-open
Beam Therapeutics (BEAM) closed up +$0.20 after Monday’s -$0.20 after Friday’s +$0.63 with a positive +$0.11 or 0.66% pre-open
Alnylam Pharmaceuticals (ALNY) closed up +$7.56 after Monday’s -$10.74 with a negative -$0.49 or -0.11% pre-open
Vericel (VCEL) closed up +$0.66 after Monday’s -$1.24 with a negative -$0.10 or -0.27% pre-open
The BOTTOM LINE: I am sick of hearing about Nvidia (NVDA) … as an indicator.
- Regardless of whether you think about NVDA shares or not, its result will impact your portfolio in some way.
Putting to the test on the coming Friday with the release of the Personal Consumption Expenditures (PCE) index, the Fed's preferred inflation measure.
- Expect core PCE inflation to peak slightly above 3% by the end of the year. With inflation drifting in the wrong direction and the labor market losing momentum, the Fed faces difficult trade-offs in balancing its dual mandate."
August: understand the “flow” …
- 8/26 - Tuesday closed positive with 25 positive, 9 negative and 1 flat
- 8/25 – Monday closed negative with 4 positive, 29 negative and 2 flats
Last week:
- 8/22 – Friday closed positive with 30 positive, 4 negative and 1 flat
- 8/21 – Thursday closed positive with 22 positive, 12 negative and 1 flat
- 8/20 - Wednesday closed negative with 14 positive, 19 negative and 2 flats
- 8/19 - Tuesday closed negative with 5 positive, 28 negative and 2 flats
- 8/18 - Monday closed positive with 18 positive, 17 negative and 0 flat
Earnings are still the highlight of the week: Meeting earnings expectation and/or missing consensus will deem share pricing outcomes.
- Earnings: 4 net incomes and 25 net losses of 29 releases to date
I also hate to be so negative or contrarian but, this is a NO spin zone and truth is its product; I can always be WRONG but, I am mostly EARLY!”
Welcome to my world of defining the “grey’ in our universe!
- I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.
Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.
Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors. All investments are subject to risks. Investors should consider investment objectives. Regulation Analyst Certification (Reg AC): The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities.
I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.
