RegMed Investors’ (RMi) pre-open: Waiting the wait

September 9, 2025 7:49am

Econs, econs; what do I see – no guarantees!

News: Alnylam Pharmaceuticals (ALNY pre-open +$3.97) commenced a private offering of $500 M aggregate principal amount of convertible senior notes due 2028. In connection with this offering, ALNY expects to grant the initial purchasers of the notes an option to purchase up to an additional $75 M aggregate principal amount of the notes. Ultragenyx Pharmaceutical Inc. (RARE pre-open $0.00) positive longer-term results from its P3 study of DTX401 AAV gene therapy for the treatment of glycogen storage disease type Ia (GSDIa); which is a rare, serious, and life-threatening disease due to an inborn error of carbohydrate metabolism and to then allow the treated liver cells to respond to normal hormonal signals intended to manage glucose, including insulin and cortisol.

Never leave an investor uninformed … I say what others won’t, so you can do what others can’t!

The cell and gene therapy sector has seen a few too many fits and starts, so …

US stock futures were rising as investors waited for a revision to jobs numbers, seen as” likely to show further labor-market weakness that could reset expectations for interest-rate cuts.

Remember that overnight and pre-open actions’ futures and markets doesn’t necessarily translate into actual trading in today’s market session.

Friday’s night’s … RMi) Closing Bell: Answer, RED is the color of the day … https://www.regmedinvestors.com/articles/14096

RegMed Investors (RMi) Research Note: Harvard Apparatus GT (OTCQB): Just another wrinkle – Q2/25’s 10-Q – liabilities exceed cash position … https://www.regmedinvestors.com/articles/13812

Tuesday: The pre-open Dow futures are UP +0.09% or (+0.42 points), the S&P futures are UP +0.07% or (+4 points) and the Nasdaq futures are UP +0.14% or (+32 points)

• U.S. stock futures were mixed and “barely” Tuesday, 9/9
• European stocks inched higher,
• Asia-Pacific markets traded mixed.

Henry’omics: We need to more than consider the economic environment to comprehend the micro re “our” universe of cell and gene therapy companies

• Monday: The Dow closed UP +114.09 points or +0.25%, the S&P closed UP +13.65 points or +0.21% while the Nasdaq closed UP +98.311 points or +0.45%
• Friday: The Dow closed DOWN -220.43 points or -0.48%, the S&P closed DOWN -20.58 points or -0.32% while the Nasdaq closed DOWN -7.306 points or -0.03%
• Last week, the Dow was lost -0.32%, the S&P 500 +0.33% and Nasdaq gained +1.14%.

Economic Data Docket: NFIB (small business) optimism index

• In the week, Wednesday’s PPI and wholesale inventories and Fed Chair Powell’s press conference at 2:30 p.m., ET, Thursday's CPI (inflation data) initial jobless claims, the weekly update on mortgage rates will be closely watched. Friday’s consumer sentiment could offer uncertain mix of upcoming inflation pressures; followed by None on Friday – Thankfully.

Q3 – September, 1 holiday, 2 negative and 3 positive closes

• August - 11 negative and 9 positive closes
• July – 1 market holiday, 13 positive and 9 negative closes

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

• Let ‘em ride, I see a “muddy” econ laden week – as Tuesday evolves; yet, some green after the red after green as September advances, along with the usual ups, downs and just plain uncertainties

The BOTTOM LINE: Econs matter in “this” market scenario; brace for inflation data this week with cracks in “our” universe … we are so dependent on econ “numbers” to our universe’s share pricing …

“Lousy” jobs numbers from August have likely forced the Fed to step in.

• But despite the near certainty that a cut is near/coming, the Fed — or the potential of the Fed's future action — still has the power to electrify the market as the focus now moves to whether we'll see a jumbo 50 basis point rate cut or the standard 25.
• How many cuts we see and how fast they come has rapidly stepped in to replace the "will they, won't they" debate.
• Ahead of two inflation reports due later this week, which aren't expected to show much progress on combating pricing pressures, the Nasdaq (^IXIC) and the S&P 500 (^GSPC) were at or near all-time highs. <Yahoo Finance>

September is historically the worst month for equities …

• Are tariffs more of an issue to the future, hope the Supreme Courts levels over-reaching state/federal courts?
• Don’t forget about Fed governor Lisa Cook and her “mortgage fraud criminal referral to DOJ>issues of being fired or not?

September is in the front window: understand the “flow”

• 9/8 - Monday closed negative with 10 positive, 28 negative and 2 flats
• 9/5 – Friday closed positive with 35 positive, 5 negative and 0 flat
• 9/4 – Thursday closed negative with 17 positive, 21 negative and 2 flats
• 9/3 – Wednesday closed positive with 22 positive, 16 negative and 2 flats
• 9/2 -Tuesday closed positive with 22 positive, 18 negative and 0 flat
• 9/1 -Monday was a holiday

Earnings are in the rear-view mirror; 4 net incomes and 25 net losses of 29 releases to date

I also hate to be so negative or contrarian but, this is a NO spin zone and truth is its product; I can always be WRONG but, I am mostly EARLY!”

Welcome to my world of defining the “grey’ in our universe!

• I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC): The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities.

 I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.