September 16, 2025 7:42am

A number of flips from a negative aftermarket to a positive pre-open in sector pricing

News: Moderna (MRNA) <see below>

Pre-Open Signals: 4 Positive and 2 Negative indications

Never leave an investor uninformed … I say what others won’t, so you can do what others can’t!

News: Moderna (MRNA +$0.06 pre-open) positive preliminary immunogenicity data for the 2025-2026 formula of Spikevax®, which targets the LP.8.1 variant of SARS-CoV-2 to help prevent COVID-19. The data from an ongoing P4 clinical trial evaluating the safety, tolerability and immunogenicity of the 2025-2026 formula of Spikevax showed, on average, greater than an 8-fold increase in neutralizing antibodies against the LP.8.1 variant in individuals 12 through 64 years of age with at least one underlying condition that puts them at high risk for severe outcomes from COVID-19, and all adults 65 years of age and older. The safety profile of the vaccine was consistent with previous studies, with no new safety concerns identified.

 

The market anticipates good Fed news and rises into it, but once the news is out, profits are sometimes taken…

Remember that overnight and pre-open actions’ futures and markets doesn’t necessarily translate into actual trading in today’s market session.

 

Monday’s night’s … RMi Closing Bell: More red than green … https://www.regmedinvestors.com/articles/14107

RMi Research note: Sanofi (SAN-PA) has frozen R&D investment decisions in the U.K. … https://www.regmedinvestors.com/articles/14106

 

Tuesday: The pre-open Dow futures are UP +0.00% or (+2 points), the S&P futures are UP +0.16% or (+11 points) and the Nasdaq futures are UP +0.24% or (+58 points)

  • Stock futures are fluctuating and barely climbing, Tuesday, 9/16
  • European markets slid lower,
  • Asia Pacific markets traded higher.

 

Henry’omics: We need to more than consider the economic environment to comprehend the micro re “our” universe of cell and gene therapy companies

  • Monday: The Dow closed UP +49.23 points or +0.11%, the S&P closed UP +30.99 points or +0.47% while the Nasdaq closed UP +207.647 points or +0.94%
  • Friday: The Dow closed DOWN -273.78 points or -0.59%, the S&P closed DOWN -3.18 points or -0.05% while the Nasdaq closed UP +98.03 points or +0.44%
  • Last week, the Dow +1.56%, S&P 500 +1.63% and the Nasdaq +1.58% al gained,
  • The previous week, the Dow lost -0.32%, the S&P 500 +0.33% and Nasdaq gained +1.14%.

Economic Data Docket: Many

  • Retail sales preliminary reading, month-on-month, August (+0.3% expected, +0.5% previously);
  • Retail sales ex auto and gas, month-on-month, August (+0.5% expected, +0.2% previously);
  • Import price index, month-on-month, August (+0.4% previously);
  • Import price index, year-on-year, August (-0.2% previously);
  • Export price index, month-on-month, August (+0.1% previously);
  • Export price index, year-on-year, August (+2.2% previously);
  • Industrial production, month-on-month, August (0.0% expected, -0.1% previously);
  • Capacity utilization, August (77.4% expected, 77.5% previously);
  • Business inventories, July (+0.2% expected, +0.2% previously);
  • NAHB Housing Market Index, September (32 previously)

 

Q3 – September, 1 holiday, 5 negative and 5 positive closes

  • August - 11 negative and 9 positive closes
  • July – 1 market holiday, 13 positive and 9 negative closes

 

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

  • Let ‘em ride, I see a “bloody” econ laden week – I see red after green as September advances, along with the usual ups, downs and just plain uncertainties

Although:

CRISPR Therapeutics (CRSP) closed up +$1.58 after Friday’s +$0.37, Thursday’s +$4.08, Wednesday’s -$1.88 with a positive +$0.06 or +0.10% pre-open

BioNTech SE (BNTX) closed up +$1.14 after Friday’s -$7.57, Thursday’s +$3.31, Wednesday’s -$1.09, Tuesday’s -$0.57 and last Monday’s -$9.80 with a positive +$0.43 or+-0.44% pre-open

Moderna (MRNA) closed up +$0.37 after Friday’s -$1.88 and Thursday’s +$1.08 with a positive +$0.06 or +0.25% pre-open

Solid Biosciences (SLDB) closed up +$0.10 after Friday’s +$0.08 with a negative -$0.01 or -0.18% pre-open

Vertex Pharmaceuticals (VRTX) closed down -$1.12 after Friday’s -$3.04, Thursday’s +$8.82, Wednesday’s -$7.93, Tuesday’s +$1.23 and last Monday’s -$0.87 with a negative -$1.53 or -0.39% pre-open

IQV Holdings (IQV) closed down -$1.25 after Friday’s -$3.47, Thursday’s +$6.77, Wednesday’s -$5.77 and last Tuesday’s +$1.99 with a positive +$0.42 or +0.23% pre-open

 

The BOTTOM LINE: Just another wait and see ...

Beyond the Fed, the calendar brings a weekly update on jobless claims and fresh manufacturing data, offers supplementary signals on the strength of the economy.

 

September is in the front window: understand the “flow”

  • 9/15 – Monday closed negative with 17 positive, 22 negative and 1 flat

Last week:

  • 9/12 - Friday closed negative with 4 negative, 34 positive and 2 flats
  • 9/11 – Thursday closed positive with 27 positive, 11 negative and 2 flats
  • 9/10 – Wednesday closed negative with 13 positive, 22 negative and 1 flat
  • 9/9 – Tuesday closed positive with 24 positive, 15 negative and 1 flat
  • 9/8 - Monday closed negative with 10 positive, 28 negative and 2 flats

The previous week:

  • 9/5 – Friday closed positive with 35 positive, 5 negative and 0 flat
  • 9/4 – Thursday closed negative with 17 positive, 21 negative and 2 flats
  • 9/3 – Wednesday closed positive with 22 positive, 16 negative and 2 flats
  • 9/2 -Tuesday closed positive with 22 positive, 18 negative and 0 flat

The beginning:

  • 9/1 -Monday was a holiday

 

Earnings are in the rear-view mirror; 4 net incomes and 25 net losses of 29 releases

Interesting stat: after HHS secretary Kennedy’s nomination, the XBI biotech index “was down 8% over the next 2 days, highlighting concern among biotech investors.” <RBC Capital>

I also hate to be so negative or contrarian but, this is a NO spin zone and truth is its product; I can always be WRONG but, I am mostly EARLY!”

Welcome to my world of defining the “grey’ in our universe!

  • I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

 

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC):

The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.