September 18, 2025 7:49am

Investors will receive another pulse check with the release of weekly jobless claims

Buy, back on the horse after a throw following a volatile day of trading

Pre-Open Signals: 6 Positive

Never leave an investor uninformed … I say what others won’t, so you can do what others can’t!

To reiterate, although not today: “my hang-up or same-old mantra, every time I see a new high; I am of the opinion to say BYE. Also, if and as the market falls back into its sideways, choppy range, sector “positions” could be back struggling and suffer.”

 

No Don Quixote … yet, I continually ask, what do all these stock sources, I-Banks and brokers do for you anyway? Technological advances and the increasing availability of data have made intel both available and complex.  I see myself as a collector and my responsibility is to lead investors to interpreted data as I bridge the gap to an investment decision.

Remember that overnight and pre-open actions’ futures and markets doesn’t necessarily translate into actual trading in today’s market session.

 

Wednesday’s night’s … RMi Closing Bell: Anticipated the expected … https://www.regmedinvestors.com/articles/14111

RMi Research note: Sanofi (SAN-PA) has frozen R&D investment decisions in the U.K. … https://www.regmedinvestors.com/articles/14106

 

Thursday: The pre-open Dow futures are UP +0.60% or (+277 points), the S&P futures are UP +0.79% or (+52 points) and the Nasdaq futures are UP +1.11% or (+272 points)

  • Futures are roaring upward, Thursday 9/18
  • European markets rose,
  • Asia-Pacific markets traded mixed

 

Henry’omics: We need to more than consider the economic environment to comprehend the micro re “our” universe of cell and gene therapy companies

  • Wednesday: The Dow closed UP +260.42 points or +0.57%, the S&P closed DOWN -6.41 points or -0.10% while the Nasdaq closed DOWN -72.63 points or -0.33%
  • Tuesday: The Dow closed DOWN -125.55 points or -0.27%, the S&P closed DOWN -8.52 points or -0.13% while the Nasdaq closed DOWN -14.79 points or -0.07%
  • Monday: The Dow closed UP +49.23 points or +0.11%, the S&P closed UP +30.99 points or +0.47% while the Nasdaq closed UP +207.647 points or +0.94%
  • Last week, the Dow was up +1.56%, S&P 500 +1.63% and the Nasdaq +1.58%
  • The previous week, the Dow lost -0.32%, the S&P 500 +0.33% and Nasdaq gained +1.14%
  • The month to date, the Dow is up 1%, the S&P 500 is up +2.3%, the Nasdaq +4%

Economic Data Docket: Initial jobless claims, week ending Sept. 13 (263,000 previously).

 

Q3 – September, 1 holiday, 6 negative and 6 positive closes

  • August - 11 negative and 9 positive closes
  • July – 1 market holiday, 13 positive and 9 negative closes

 

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

  • Let ‘em ride, I see yet another econ – I see more green as September continues to close to the end of the Q, along with the usual ups, downs and just plain uncertainties

A long with:

Alnylam Pharmaceuticals (ALNY) closed down -$9.51 with a positive +$3.51 or +0.78% pre-open

CRISPR Therapeutics (CRSP) closed down -$2.12 after Tuesday’s +$3.35, Monday’s +$1.58, Friday’s +$0.37 and last Thursday’s +$4.08 with a positive +$2.10 or +3.56% pre-open

BioNTech SE (BNTX) closed down -$1.11 after Tuesday’s +$1.38, Monday’s +$1.14, Friday’s -$7.57 and last Thursday’s +$3.31 with a positive +$1.28 or +1.30% pre-open

Moderna (MRNA) closed up +$0.16 after Tuesday’s +$0.96, Monday’s +$0.37, Friday’s -$1.88 and Thursday’s +$1.08 with a positive +$0.46 or +1.84% pre-open

Vertex Pharmaceuticals (VRTX) closed down-$4.21 after Tuesday’s -$1.85, Monday’s -$1.12, Friday’s -$3.04 and last Thursday’s +$8.82 with a positive +$1.63 or +0.42% pre-open

IQV Holdings (IQV) closed down -$0.12 after Tuesday’s +$0.84, Monday’s -$1.25, Friday’s -$3.47 and last Thursday’s +$6.77 with a positive +$0.96 or +0.51% pre-open

 

The BOTTOM LINE: A whipsaw after a bumpy ride? I’m in …

After a sector downdraft, post the Fed rate decision, jobless claims and fresh manufacturing data, offers a trend signal on the breath of the sector.

  • Existing in the realm, the stock market often has a day two reaction to Fed meetings.
  • Investors add exposure or to make new buys or add-on purchases while cutting relative laggards.
  • Then, if you're stepping on the gas, be ready to slam on the breaks. Know your speed limit.

September is in the front window: understand the “flow”

  • 9/17 – Wednesday closed negative with 10 positive, 30 negative and 0 flat
  • 9/16 – Tuesday closed positive with 29 positive, 9 negative and 2 flats
  • 9/15 – Monday closed negative with 17 positive, 22 negative and 1 flat
  • 9/11 – Thursday closed positive with 27 positive, 11 negative and 2 flats
  • 9/10 – Wednesday closed negative with 13 positive, 22 negative and 1 flat

Q2 Earnings are in the rear-view mirror; we are about to start again …!

I also hate to be so negative or contrarian but, this is a NO spin zone and truth is its product; I can always be WRONG but, I am mostly EARLY!”

Welcome to my world of defining the “grey’ in our universe!

  • I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

 

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC):

The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.