September 19, 2025 7:45am

Yesterday’s gas, today hit the brakes

To reiterate: “my hang-up or same-old mantra, every time I see a new high; I am of the opinion to say BYE. Yesterday’s cell and gene therapy sector bolted skyward as the Nasdaq grew more extended, I believe the risks are still relevant, some sells and buys

News: Ionis Pharmaceuticals (IONS +$0.12 or +0.41 to $29.23 pre-open) <see below>

Pre-Open Signals: 5 Positive, 1 Negative and 1 Sell into Strength

Never leave an investor uninformed … I say what others won’t, so you can do what others can’t!

 

News: Ionis Pharmaceuticals (IONS closed +$0.40 or +1.39%) and Sobi® announced that TRYNGOLZA® (olezarsen) has been approved in the European Union (EU) as an adjunct to diet in adult patients for the treatment of genetically confirmed familial chylomicronemia syndrome (FCS). The approval follows the positive opinion of the Committee for Medicinal Products for Human Use.

Remember that overnight and pre-open actions’ futures and markets doesn’t necessarily translate into actual trading in today’s market session.

 

Thursday’s night’s … RMi Closing Bell: Up, up and away … https://www.regmedinvestors.com/articles/14113

RMi Research Note: Harvard Apparatus GT (OTCQB): Who is wasting lipstick on this pig? … https://www.regmedinvestors.com/articles/13812

 

Friday: The pre-open Dow futures are UP +0.11% or (+50 points), the S&P futures are UP +0.13% or (+9 points) and the Nasdaq futures are UP +0.12% or (+29.50 points)

  • Stock futures are positive yet barely moving, Friday 9/19
  • European markets were initially higher,
  • Asia-Pacific markets traded mostly higher.

 

Henry’omics: We need to more than consider the economic environment to comprehend the micro re “our” universe of cell and gene therapy companies

  • Thursday: The Dow closed UP +124.10 points or +0.27%, the S&P closed UP +31.61 points or +0.48% while the Nasdaq closed UP +209.399 points or +0.94%
  • Wednesday: The Dow closed UP +260.42 points or +0.57%, the S&P closed DOWN -6.41 points or -0.10% while the Nasdaq closed DOWN -72.63 points or -0.33%
  • Tuesday: The Dow closed DOWN -125.55 points or -0.27%, the S&P closed DOWN -8.52 points or -0.13% while the Nasdaq closed DOWN -14.79 points or -0.07%
  • Monday: The Dow closed UP +49.23 points or +0.11%, the S&P closed UP +30.99 points or +0.47% while the Nasdaq closed UP +207.647 points or +0.94%
  • This week to date: The Dow is up +0.7%, the S&P 500 +0.7% and the Nasdaq +1.5%.
  • Last week, the Dow was up +1.56%, S&P 500 +1.63% and the Nasdaq +1.58%
  • The previous week, the Dow lost -0.32%, the S&P 500 +0.33% and Nasdaq gained +1.14%

Economic Data Docket: No economic releases

 

Q3 – September, 1 holiday, 6 negative and 7 positive closes

  • August - 11 negative and 9 positive closes
  • July – 1 market holiday, 13 positive and 9 negative closes

 

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

  • September continues to close to the Q, along with the usual ups, downs and just plain uncertainties

A long with:

Intellia Therapeutics (NTLA +$3.70 after Wednesday’s +$0.14 after Tuesday’s +$0.70 after Monday’s +$0.15 with a negative -$0.49 or -3.04% pre-open

CRISPR Therapeutics (CRSP) closed up +3.87 after Wednesday’s -$2.12, Tuesday’s +$3.35, Monday’s +$1.58 and last Friday’s +$0.37 with a positive +$0.26 or +0.41% pre-open – Sell into Strength

BioNTech SE (BNTX) closed down -$1.84 after Wednesday’s -$1.11, Tuesday’s +$1.38, Monday’s +$1.14 and last Friday’s -$7.57 with a positive +$0.19 or +0.20% pre-open

Vertex Pharmaceuticals (VRTX) closed down -$0.04 after Wednesday’s -$4.21, Tuesday’s -$1.85, Monday’s -$1.12 and last Friday’s -$3.04 with a positive +$0.20 or +0.06% pre-open

Alnylam Pharmaceuticals (ALNY) closed up +$0.45 after Wednesday’s -$9.51 with a positive +$2.50 or +0.55% pre-open

Moderna (MRNA) closed up +$0.45 after Wednesday’s +$0.16, Tuesday’s +$0.96, Monday’s +$0.37 and last Friday’s -$1.88 with a positive +$0.13 or +0.51% pre-open

IQV Holdings (IQV) closed up +$3.51 after Wednesday’s -$0.12, Tuesday’s +$0.84, Monday’s -$1.25 and last Friday’s -$3.47 with a positive +$0.02 or +0.01% pre-open

 

The BOTTOM LINE: A bumpy Friday ride? TGIF ...

At 5.1% above the 50-day line, the Nasdaq is just starting to get extended. The S&P 500 is not stretched.

The buzz: Trump on Thursday set high expectations for his conversation with Xi, which is set to take place at 9:00 a.m. ET Friday. The president described a TikTok deal as all but completed and emphasized he is hopeful the two countries can negotiate over trade. "On a much bigger scale, we're pretty close to a deal," Trump said about talks with China. <Yahoo Finance>

September is in the front window: understand the “flow”

  • 9/18 – Thursday closed positive with 33 positive, 6 negative and 1 flat
  • 9/17 – Wednesday closed negative with 10 positive, 30 negative and 0 flat
  • 9/16 – Tuesday closed positive with 29 positive, 9 negative and 2 flats
  • 9/15 – Monday closed negative with 17 positive, 22 negative and 1 flat

Q2 Earnings are in the rear-view mirror; we are about to start again … Q3!

I also hate to be so negative or contrarian but, this is a NO spin zone and truth is its product; I can always be WRONG but, I am mostly EARLY!”

Welcome to my world of defining the “grey’ in our universe!

  • I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

 

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC):

The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.