RMi pre-open: Stalled or mauled

September 24, 2025 7:34am

While inching towards Thursday’s jobless claims, GDP (3^rd estimate), durable goods, existing home sales and retail inventories before crawling to the Personal Consumption Expenditures (PCE) index and consumer sentiment on Friday

Also, prepping for the end of September as Q3 is coming to a close – 5 sessions to go

Pre-Open Signals: Weak aftermarket and nebulous pre-open

News: uniQure NV (QURE +$0.43 or +3.15% to $13.66 pre-open) Refinances existing $50 M Debt and securing an additional $125 M in Non-Dilutive funding

Never leave an investor uninformed … I say what others won’t, so you can do what others can’t!

News: uniQure N.V.  (QURE) entered into a $175 million non-dilutive senior secured term loan facility with Hercules Capital, Inc. (NYSE: HTGC) to fund the potential commercial launch of AMT-130, its investigational gene therapy for the treatment of Huntington’s disease.

Remember that overnight and pre-open actions’ futures and markets doesn’t necessarily translate into actual trading in today’s market session.

The cell and gene therapy sector has responded in its usual alternating trend as I have written “econs have been poison” to our universe

I answer or qualify the sector’s equity’s movement; with an emphasis on which company is gaining or losing stride in your portfolio for the short-term striving toward the near and longterm

Tuesday night’s … RMi Closing Bell: Giving back gains … https://www.regmedinvestors.com/articles/14119

Updated … RMi Research Note: Harvard Apparatus GT (OTCQB): Who is wasting lipstick on this pig? … https://www.regmedinvestors.com/articles/13812

Wednesday: The pre-open Dow futures are UP +0.05% or (+25 points), the S&P futures are UP +0.20% or (+13 points) and the Nasdaq futures are UP +0.33% or (+82 points)

• Stock futures ticked “barely” higher Wednesday, 9/24
• European shares inched lower,
• Asia-Pacific markets were mixed and falling.

Henry’omics: We need to more than consider the economic environment to comprehend the micro re “our” universe of cell and gene therapy companies

• Tuesday: The Dow closed DOWN -88.76 points or -0.19%, the S&P closed DOWN -36.83 points or -0.65% while the Nasdaq closed DOWN -215.503 points or -0.95%
• Monday: The Dow closed UP +66.27 points or +0.14%, the S&P closed UP +29.39 points or +0.44% while the Nasdaq closed UP +157.50 points or +0.70%
• Friday: The Dow closed UP +172.856 points or +0.37%, the S&P closed UP +32.40 points or +0.49% while the Nasdaq closed UP +160.751 points or +0.72%
• Last week: The Dow was up +1%, the S&P 500 +1.2% and the Nasdaq +2.2%.

Economic Data Docket: New home sales - Aug., San Francisco Fed President Mary Daly speech oversight responsible for Silicon Valley Bank bankruptcy

Q3 – September, 1 holiday, 8 negative and 8 positive closes

• August - 11 negative and 9 positive closes
• July – 1 market holiday, 13 positive and 9 negative closes

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

• I see red after as September continues to close with more econs coming and proximity to the Q’s end, along with the usual ups, downs and just plain uncertainties
• Passing …

The BOTTOM LINE: “It’s always darkest before the pitch dark” …

• The stock market rally retreated Tuesday as the Nasdaq led a retreat from record highs.
• Tuesday, the Dow fell 0.2%, the S&P 500 declined 0.55% and the Nasdaq declined 0.95% while the small-cap Russell 2000 surrendered -0.2%.
• The Nasdaq is up 5% versus the 50-day line after hitting 6.2% at Monday's close

September is in the front window: understand the “flow”

• 9/23 – Tuesday closed negative with 7 positive, 32 negative and 1 flat
• 9/22 - Monday closed positive with 31 positive, 9 negative and 0 flat

Last week:

• 9/19 – Friday closed negative with 7 positive, 33 negative and 0 flat
• 9/18 – Thursday closed positive with 33 positive, 6 negative and 1 flat
• 9/17 – Wednesday closed negative with 10 positive, 30 negative and 0 flat
• 9/16 – Tuesday closed positive with 29 positive, 9 negative and 2 flats
• 9/15 – Monday closed negative with 17 positive, 22 negative and 1 flat

September has historically delivered pullbacks, yet, this year’s 2025 market has defied that pattern — climbing 35% since March with strong technical and fundamental tailwinds,

Q2 Earnings are in the rear-view mirror; we are about to start again … Q3!

I also hate to be so negative or contrarian but, this is a NO spin zone and truth is its product; I can always be WRONG but, I am mostly EARLY!”

Welcome to my world of defining the “grey’ in our universe!

• I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC):

The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.