September 30, 2025 8:22am

September and Q3’s end and “uncle algo and his electronic trading dwarfs” are looking for a pre-paid lunch by your portfolio

The risk of a looming midweek government shutdown needs to be taken SERIOUSLY as to indexes and their drivers, risks of even higher volatility, confidence, moving forward a destabilizing influence, driving another flight to safety and to a sputtering economy

Never leave an investor uninformed … I say what others won’t, so you can do what others can’t!

Always be vigilant … why you need to read RMi concerning your cell and gene therapy portfolio holdings

Remember that overnight and pre-open actions’ futures and markets doesn’t necessarily translate into actual trading in today’s market session.

 

Monday night’s … RMi Closing Bell: Count-down … https://www.regmedinvestors.com/articles/14127

Updated … RMi Research Note: Harvard Apparatus GT (OTCQB): Who is wasting lipstick on this pig? … https://www.regmedinvestors.com/articles/13812

 

 

Tuesday: The pre-open Dow futures are DOWN -0.21% or (-97 points), the S&P futures are DOWN -0.17% or (-12 points) and the Nasdaq futures are DOWN -0.14% or (-35 points)

Stock futures fell Tuesday, 9/30 as a shutdown loomed,

European stocks fell,

Asia-Pacific markets trade mixed.

 

Henry’omics: We need to more than consider the markets …environment to comprehend the micro re “our” universe of cell and gene therapy companies

  • Monday: The Dow closed UP +68.78 points or +0.15%, the S&P closed UP +17.51 points or +0.26% while the Nasdaq closed UP +107.085 points or +0.48%
  • Friday: The Dow closed UP +299.97 points or +0.65%, the S&P closed UP +38.98 points or +0.59% while the Nasdaq closed UP +99.371 points or +0.44%
  • Last week, the Dow has shed 0.8%, the S&P 500 is down nearly 0.9% and the Nasdaq has lost about 1.1%
  • The previous week: The Dow was up +1%, the S&P 500 +1.2% and the Nasdaq +2.2%.

Economic Data Docket: S&P Case-Shiller home price index (20 cities) – July, Chicago Business Barometer (PMI) - Sept., Job openings - Aug., Consumer confidence. 3 fed Presidents and a vice-chair speak that no investors want to hear

Q3 – September, 1 holiday, 9 negative and 11 positive closes

  • August - 11 negative and 9 positive closes
  • July – 1 market holiday, 13 positive and 9 negative closes

 

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

  • I see red after as September continues to close with more econs coming and proximity to the Q’s end, along with the usual ups, downs and just plain uncertainties

Passing … as econs seem to dissolve share pricing or so it has!

 

The BOTTOM LINE: I can’t seem to let go of this quote, “It’s always darkest before the pitch dark” …

  • President Trump met with Democrats in the Oval Office on Monday, but both sides left the talks indicating they had made no progress on striking a deal that would avert a government shutdown. Lawmakers have until Wednesday at 12:01 a.m. ET to reach an agreement or else a partial government shutdown is set to begin. <Yahoo Finance>
  • A government shutdown could suspend the release of the jobs report and other economic data. Usually, markets aren't that affected by a shutdown initially, but could weigh on stocks and bonds if it persists.

The cell and gene therapy sector usually responds to alternating trend as I have written “econs have been poison” to our universe

  • With the cell and gene therapy sector seeing a few too many fits and starts, so …

September is in the front window: understand the “flow”

  • 9/29 – Monday closed positive with 33 positive, 5 negative and 2 flats
  • 9/26 – Friday closed positive with 29 positive, 9 negative and 2 flats
  • 9/25 – Thursday closed negative with 8 positive, 30 negative and 2 flats
  • 9/24 – Wednesday closed positive with 28 positive, 11 negative and 1 flat
  • 9/23 – Tuesday closed negative with 7 positive, 32 negative and 1 flat
  • 9/22 - Monday closed positive with 31 positive, 9 negative and 0 flat

Last week:

  • 9/19 – Friday closed negative with 7 positive, 33 negative and 0 flat
  • 9/18 – Thursday closed positive with 33 positive, 6 negative and 1 flat
  • 9/17 – Wednesday closed negative with 10 positive, 30 negative and 0 flat
  • 9/16 – Tuesday closed positive with 29 positive, 9 negative and 2 flats
  • 9/15 – Monday closed negative with 17 positive, 22 negative and 1 flat

The previous weeks:

  • 9/12 - Friday
  • 9/11 – Thursday closed positive with 27 positive, 11 negative and 2 flats
  • 9/10 – Wednesday closed negative with 13 positive, 22 negative and 1 flat
  • 9/9 – Tuesday closed positive with 24 positive, 15 negative and 1 flat
  • 9/8 - Monday closed negative with 10 positive, 28 negative and 2 flats

Starting the month:

  • 9/5 – Friday closed positive with 35 positive, 5 negative and 0 flat
  • 9/4 – Thursday closed negative with 17 positive, 21 negative and 2 flats
  • 9/3 – Wednesday closed positive with 22 positive, 16 negative and 2 flats
  • 9/2 -Tuesday closed positive with 22 positive, 18 negative and 0 flat
  • 9/1 -Monday was a holiday

 

September has historically delivered pullbacks, yet, this year’s 2025 market has defied that pattern — climbing 35% since March with strong technical and fundamental tailwinds,

Q2 Earnings are in the rear-view mirror; we are about to start again … Q3!

I also hate to be so negative or contrarian but, this is a NO spin zone and truth is its product; I can always be WRONG but, I am mostly EARLY!”

Welcome to my world of defining the “grey’ in our universe!

  • I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

 

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC):

The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.