October 1, 2025 7:39am
The power of consequences ...
Government shuts, market and sector cuts; although history shows that traders usually take U.S. government shutdowns in stride
September and Q3’s ended Tuesday capping another strong month and Q3
Pre-open Signals: 1 Positive and 4 Negative Indications
Never leave an investor uninformed … I say what others won’t, so you can do what others can’t!
Always be vigilant … why you need to read RMi concerning your cell and gene therapy portfolio holdings
Remember that overnight and pre-open actions’ futures and markets doesn’t necessarily translate into actual trading in today’s market session.
Tuesday night’s … RMi Closing Bell: Sector’s pricing secured … https://www.regmedinvestors.com/articles/14130
Wednesday: The pre-open Dow futures are DOWN -0.41% or (-193 points), the S&P futures are -0.47% or (-31 points) and the Nasdaq futures are DOWN -0.51% or (-127 points)
- Futures tumble raising fear, Wednesday 10/1
- European markets opened mixed,
- Asia Pacific markets traded mixed
Henry’omics: We need to more than consider the markets …environment to comprehend the micro re “our” universe of cell and gene therapy companies
- Tuesday: The Dow closed UP +81.82 points or +0.18%, the S&P closed UP +27.25 points or +0.41% while the Nasdaq closed UP +68.855 points or +0.31%
- Monday: The Dow closed UP +68.78 points or +0.15%, the S&P closed UP +17.51 points or +0.26% while the Nasdaq closed UP +107.085 points or +0.48%
- Last week, the Dow has shed 0.8%, the S&P 500 is down nearly 0.9% and the Nasdaq has lost about 1.1%
- The month and Q3’s numbers, the S&P 500 Q is up 7% and the month -4.2%, the Nasdaq’s Q is up +11% and the month +5% while the Dow’s Q is up +5% and the month +1%
Economic Data Docket: Maybe
- ADP employment - Sept., S&P final U.S. manufacturing PMI - Sept., Construction spending- Aug., ISM manufacturing - Sept., Auto sales
Q4 – 1st session
Q3 – September, 1 holiday, 9 negative and 12 positive closes; August - 11 negative and 9 positive closes; July – 1 market holiday, 13 positive and 9 negative closes
Companies in my headlights – It’s your decision; I provide ideas and context
I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths. A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.
- October begins … with a new shutdown hurdle along with the usual ups, downs and just plain uncertainties
IQV Holdings (IQV) closed up +$9.22 after Monday’s +$1.17 with a negative -$0.19 or -0.10% pre-open
Lenz Therapeutics (LENZ) closed up +$1.69 after Monday’s +$2.86 with a positive +$0.62 or +1.33% pre-open
CRISPR Therapeutics (CRSP) closed up +$1.04 after Monday’s +$2.10 with a negative -$0.37 or -0.57% pre-open
Vertex (VRTX) closed down -$3.67 after Monday’s +$9.58 with a negative -$0.19 or -0.05% pre-open
uniQure NV (QURE) closed down -$1.03 after Monday’s +$5.09 with a negative -$0.40 or -0.69% pre-open
The BOTTOM LINE: I can’t seem to let go of this quote, “It’s always darkest before the pitch dark” …
- The cell and gene therapy sector ended seeing a few too many fits and starts, so …
Tuesday, the 10-year Treasury yield rose 1 basis point to 4.15%. A lengthy government shutdown could unnerve bond markets. The government won't release economic data during a shutdown, including the September jobs report schedule for Friday.
Q2 Earnings are in the rear-view mirror; we start again … Q3 earnings!
I also hate to be so negative or contrarian but, this is a NO spin zone and truth is its product; I can always be WRONG but, I am mostly EARLY!”
Welcome to my world of defining the “grey’ in our universe!
- I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.
Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.
Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors. All investments are subject to risks. Investors should consider investment objectives. Regulation Analyst Certification (Reg AC):
The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.
