October 6, 2025 7:50am

The federal government shutdown entering another week; the cell and gene therapy sector looks to build on a strong run that pushed its equities to fresh highs

Pre-open Signals: 9 Positive and 3 Negative Indications

News: Regenxbio (RGNX +$0.12 or +1.15% to $10.55 pre-open) completed enrollment in the ATMOSPHERE® and ASCENT® pivotal studies evaluating surabgene lomparvovec (sura-vec, ABBV-RGX-314) in wet age-related macular degeneration (wet AMD) using subretinal delivery.

Never leave an investor uninformed … I say what others won’t, so you can do what others can’t!

Ride ’em portfolio; knowing that “uncle algo and his electronic trading dwarfs” are scheming to sell some multiple session uplifts. Also, missing econ data hasn’t derailed the market’s (recent) record run

Remember that overnight and pre-open actions’ futures and markets doesn’t necessarily translate into actual trading in today’s market session.

 

Friday night’s … RMi Closing Bell: Sentiment’s not a hostage … https://www.regmedinvestors.com/articles/14136

 

Monday: The pre-open Dow futures are UP +0.17% or (78 points), the S&P futures are UP +0.31% or (+21 points) and the Nasdaq futures are UP +0.65% or (+161 points)

  • Stock futures tick higher on Monday, 10/6
  • European markets dived reacting to the shock resignation of France’s Prime Minister Sebastien Lecornu,
  • Asia Pacific markets were mixed; Chinese and South Korean markets were closed for holidays.

 

Henry’omics: We need to more than consider the markets …environment to comprehend the micro re “our” universe of cell and gene therapy companies

  • Friday: The Dow closed UP +238.56 points or +0.51%, the S&P closed UP +0.44 points or +0.01% while the Nasdaq closed DOWN -63.545 points or -0.28%
  • Thursday: The Dow closed UP +78.62 points or +0.17%, the S&P closed UP +4.15 points or +0.06% while the Nasdaq closed UP +88.894 points or +0.39%
  • Wednesday: The Dow closed UP +43.21 points or +0.09%, the S&P closed UP +22.74 points or +0.34% while the Nasdaq closed UP +95.148 points or +0.422%
  • Tuesday: The Dow closed UP +81.82 points or +0.18%, the S&P closed UP +27.25 points or +0.41% while the Nasdaq closed UP +68.855 points or +0.31%
  • Last Monday: The Dow closed UP +68.78 points or +0.15%, the S&P closed UP +17.51 points or +0.26% while the Nasdaq closed UP +107.085 points or +0.48%
  • Last week, the Dow was up +1.3%, the S&P 500 is +1.1% and the Nasdaq has lost about 1.3%
  • Last month and Q3’s numbers, the S&P 500 Q was up +7% and the month -4.2%, the Nasdaq’s Q is up +11% and the month +5% while the Dow’s Q is up +5% and the month +1%

Economic Data Docket: None

 

Q4 – 3 positive closes

  • Q3 – September, 1 holiday, 9 negative and 12 positive closes; August - 11 negative and 9 positive closes; July – 1 market holiday, 13 positive and 9 negative closes

 

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

  • October begins with a government shutdown and fewer econs… along with the usual ups, downs and just plain uncertainties

Some indications in MY view:

IQV Holdings (IQV0 closed up +$2.29 with a positive +$0.41 or +0.20% pre-open

Arrowhead Pharmaceuticals (ARWR) closed up +$1.52 after Thursday’s -$0.41 with a positive +0.18 or +0.50% pre-open

Mesoblast (MESO) closed up +$1.39 with a negative -1.02 or -5.54% pre-open

BioNTech (BNTX) closed up +$0.98 after Thursday’s +$2.30 after Wednesday’s +$3.59 and Tuesday’s +$0.52 with a negative -$0.59 or -0.56% pre-open

Lenz Therapeutics (LENZ) closed up +$0.42 after Thursday’s -$0.73, Wednesday’s +$2.47, Tuesday’s +$1.69 and last Monday’s +$2.86 with a positive +$1.15 or +2.36% pre-open

uniQure NV (QURE) closed up +$0.42 after Thursday’s -$0.49, Wednesday’s -$3.38, Tuesday’s -$1.03 and last Monday’s +$5.09 with a positive +1,62 or +2.95% pre-open

Vertex (VRTX) closed down -$5.55 after Thursday’s +$4.64, Wednesday’s +$12.57, Tuesday’s -$3.67 and Monday’s +$9.58 with a positive +$2.32 or +0.58% pre-open

CRISPR Therapeutics (CRSP -$5.08 after Thursday’s +$6.66, Wednesday’s +$1.35, Tuesday’s +$1.04 and Monday’s +$2.10 with a positive +$1.66 or +2.45% pre-open

Alnylam Pharmaceuticals (ALNY) closed down -$4.64 with a negative -$1.25 or -0.27% pre-open

Intellia Therapeutics (NTLA) closed down -$0.48 after Thursday’s +$1.68 and Wednesday’s +$1.49 with a positive +$1.03 or +5.16% pre-open

Prime Medicine (PRME) closed down -$0.35 after Thursday’s +$1.08 with a positive +$0.42 or +6.65% pre-open

Regenxbio (RGNX) closed down -$0.15 with a positive pre-open indication of +$0.12 or +1.15% to $10.55 on news of completing enrollment in the ATMOSPHERE® and ASCENT® pivotal studies.

 

The BOTTOM LINE: I can’t seem to let go of this quote, “It’s always darkest before the pitch dark”

  • The cell and gene therapy sector ended September seeing a few too many fits and starts, to ascend in October with 7 positive sector closes of last 9 sessions could set a trap for “some” profiteering
  • Although "All news is good news, and no news matters. By not releasing jobless report theirs 2 less impediment in the market’s relentless rise.

 

Reiterating, “What to Do Now: The stock market rally continues to do well, but … with the major indexes all near record highs … “uncle algo and his electronic trading dwarfs” are smelling some profits!”

 

Welcome to my world of defining the “grey’ in our universe!

  • I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

 

October: understand the new “flow” …

Last week:

  • 10/3 – Friday closed positive with 27 positive, 10 negative and 3 flats
  • 10/2 – Thursday closed positive with 26 positive, 13 negative and 1 flat
  • 10/1 – Wednesday closed positive with 26 positive, 14 negative and 0 flat
  • 9/30 - Tuesday closed positive with 24 positive, 15 negative and 1 flat
  • 9/29 – Monday closed positive with 33 positive, 5 negative and 2 flats

The previous week:

  • 9/26 – Friday closed positive with 29 positive, 9 negative and 2 flats
  • 9/25 - Thursday closed negative with 8 positive, 30 negative and 2 flat
  • 9/24 – Wednesday closed positive with 28 positive, 11 negative and 1 flat
  • 9/23 – Tuesday closed negative with 7 positive, 32 negative and 1 flat
  • 9/22 – Monday closed positive with 31 positive, 9 negative and 0 flat

 

Q3 Earnings are in the front-view mirror; we are about to start again …!

 

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC):

The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.