October 10, 2025 7:44am

After 5 positive, 2 negative October closes in the 10th day of government shutdown

The advance/decline line depreciates while struggling to find catalysts

Still under the impression of “new highs, I say BYE”; as earnings LPS (loss-per-share) season sets ready to release an onset of valuation depreciation

Pre-open Signals: Emphasis on non-indications in aftermarket/pre-open

Never leave an investor uninformed … I say what others won’t, so you can do what others can’t!

TGIF, prepare for a holiday long weekend and thanks!

Remember that overnight and pre-open actions’ futures and markets doesn’t necessarily translate into actual trading in today’s market session.

Thursday night’s … RMi Closing Bell: Slow slippage … https://www.regmedinvestors.com/articles/14143

Are we sitting in a duck blind waiting for something to aim at or disembark for a warm brandy tosty?

 

Friday: The pre-open Dow futures are UP +0.09% or (+43 points), the S&P futures are UP +0.08% or (+5 points) and the Nasdaq futures are UP +0.09% or (+22 points)

  • Stock futures were up yet moving minimally on Friday 10/10,
  • Europe stocks traded in mixed
  • Asian Pacific shares mostly fell except for South Korea's Kospi,

 

Henry’omics: We need to more than consider the markets …environment to comprehend the micro re “our” universe of cell and gene therapy companies

  • Thursday: The Dow closed DOWN -243.36 points or -0.52%, the S&P closed DOWN -18.61 points or -0.28% while the Nasdaq closed DOWN -18.752 points or -0.08%
  • Wednesday: The Dow closed DOWN -1.20 points or -0.00%, the S&P closed UP +39.13 points or +0.58% while the Nasdaq closed UP +255.015 points or +1.12%
  • Tuesday: The Dow closed DOWN -82.16 points or -0.18%, the S&P closed DOWN -25.69 points or -0.38% while the Nasdaq closed DOWN -153.304 points or -0.67%
  • Monday: The Dow closed DOWN -63.31 points or -0.14%, the S&P closed UP +24.49 points or +0.36% while the Nasdaq closed UP +161.161 points or +0.71%
  • The week to date, Dow, is down -0.9%, the S&P 500 up +0.03% and the Nasdaq +1.1%,
  • Last week, the Dow was up +1.3%, the S&P 500 is +1.1% and the Nasdaq has lost about 1.3%
  • Last month and Q3’s numbers, the S&P 500 Q was up +7% and the month -4.2%, the Nasdaq’s Q is up +11% and the month +5% while the Dow’s Q is up +5% and the month +1%

Economic Data Docket: The University of Michigan's consumer sentiment reading is at 10 a.m. ET. 

 

Q4 – 5 positive and 2 negative closes

  • Q3 – September, 1 holiday, 9 negative and 12 positive closes; August - 11 negative and 9 positive closes; July – 1 market holiday, 13 positive and 9 negative closes

 

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

  • October began with a government shutdown and much fewer econs… along with the usual ups, downs
  • Now uncertainty rules

 

The BOTTOM LINE: I can’t seem to let go of this quote, “It’s always darkest before the pitch dark”

Reiterating, “uncle algo and his electronic trading dwarfs” are smelling some FURTHER profits!”

  • The shutdown entered its 10th day on Friday, with lawmakers still unable to agree on a funding bill. The Senate failed for a 7th time to advance stopgap measures.

Reiterating, “After multiple uplifting sessions, the cell and gene therapy sector remains profitable after being timed out …

  • The crystals and mood rings are muted as shutdown puts off scheduled data releases, including the jobless claims update that had been due; putting the focus decisively on coming Q3 earnings, watched for insight into the economy's health.
  • I remain a skeptic, as electronic trading remains the impetus to, I believe the cell and gene therapy sector gets artificially … high and low” … as proven in past sessions by “uncle algo and his electronic trading dwarfs”!
  • Keep your wallet closed!

When dramatic upsides occur, investors are often unsure exactly what to do, but they frequently act as if they do confidently know the best path forward – don’t be LULLED into an uncertainty position!

The Fed's September FOMC meeting points to interest rate cuts to come in Q4/2025.

Welcome to my world of defining the “grey’ in our universe!

  • I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

October: understand the new “flow” …

This week:

  • 10/9 - Thursday closed positive with 21 positive, 19 negative and 0 flat
  • 10/8 – Wednesday closed positive with 29 positive, 10 negative and 1 flat
  • 10/7 – Tuesday closed negative with 15 positive, 25 negative and 0 flat
  • 10/6 – Monday closed negative with 17 positive, 22 negative and 1 flat

Last week:

  • 10/3 – Friday closed positive with 27 positive, 10 negative and 3 flats
  • 10/2 – Thursday closed positive with 26 positive, 13 negative and 1 flat
  • 10/1 – Wednesday closed positive with 26 positive, 14 negative and 0 flat

Q3 Earnings are in the front-view mirror; we are about to start again …!

 

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC):

The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.