October 13, 2025 8:46am

Rebounding from Friday’s sell-off and back on the merry-go-round

The government shutdown continues into another week as a major payrolls deadline looms

The bond market is closed due to the Columbus Day holiday

Pre-open Signals: 9 Positive and 2 Negative Indications

Never leave an investor uninformed … I say what others won’t, so you can do what others can’t!

Remember that overnight and pre-open actions’ futures and markets doesn’t necessarily translate into actual trading in today’s market session.

Friday night’s … RMi Closing Bell: Smack down … https://www.regmedinvestors.com/articles/14145

 

Monday: The pre-open Dow futures are UP +0.84% or (+383 points), the S&P futures are UP +1.19% or (+78 points) and the Nasdaq futures are UP +1.76% or (+428 points)

  • U.S. stock futures rose Monday, 10/13,
  • European stocks were higher,
  • Asia-Pacific markets fell.

 

Henry’omics: We need to more than consider the markets …environment to comprehend the micro re “our” universe of cell and gene therapy companies

  • Friday: The Dow closed DOWN -878.82 points or -1.92%, the S&P closed DOWN -182.60 points or -2.71% while the Nasdaq closed DOWN -820.196 points or -3.56%
  • Thursday: The Dow closed DOWN -243.36 points or -0.52%, the S&P closed DOWN -18.61 points or -0.28% while the Nasdaq closed DOWN -18.752 points or -0.08%
  • Wednesday: The Dow closed DOWN -1.20 points or -0.00%, the S&P closed UP +39.13 points or +0.58% while the Nasdaq closed UP +255.015 points or +1.12%
  • Tuesday: The Dow closed DOWN -82.16 points or -0.18%, the S&P closed DOWN -25.69 points or -0.38% while the Nasdaq closed DOWN -153.304 points or -0.67%
  • Monday: The Dow closed DOWN -63.31 points or -0.14%, the S&P closed UP +24.49 points or +0.36% while the Nasdaq closed UP +161.161 points or +0.71%
  • The week to date, Dow, is down -0.9%, the S&P 500 up +0.03% and the Nasdaq +1.1%,
  • Last week, the Dow was up +1.3%, the S&P 500 is +1.1% and the Nasdaq has lost about 1.3%
  • Last month and Q3’s numbers, the S&P 500 Q was up +7% and the month -4.2%, the Nasdaq’s Q is up +11% and the month +5% while the Dow’s Q is up +5% and the month +1%

 

Q4 – 5 positive and 3 negative closes

  • Q3 – September, 1 holiday, 9 negative and 12 positive closes; August - 11 negative and 9 positive closes; July – 1 market holiday, 13 positive and 9 negative closes

 

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

  • October began with a government shutdown and much fewer econs… along with the usual ups, downs
  • Now uncertainty rules

Although:

Alnylam Pharmaceuticals (ALNY +$3.51 after Thursday’s +$6.27, Wednesday’s -$8.90, Tuesday’s +$7.58 and last Monday’s -$4.35 with a positive +0.70 or +0.15% pre-open

Arrowhead Pharma (ARWR) closed down -$0.65 with a negative -$0.07 or -0.20% pre-open

Lenz Therapeutics (LENZ) closed down -$7,46 after Thursday’s -$2,35, Wednesday’s +$1.66, Tuesday’s -$0.83 and last Monday’s -$2.63 with a positive +$1.77 or +4.56% pre-open

Vertex (VRTX) closed down -$7.07 after Thursday’s -$6.29, Wednesday’s +$10.87, Tuesday’s +$7.38 and last Monday’s -$0.40 with a positive +$11.09 or +2.72% pre-open

IQV Holdings (IQV) closed down -$4.83 after Thursday’s +$2.41, Wednesday’s -$0.26, Tuesday’s -$4.16 and last Monday’s -$1.59 with a negative -$0.07 or -0.04% pre-open

BioNTech (BNTX) closed down -$2.42 after Thursday’s-$1.80 with a positive +1.14 or +1.12% pre-open

uniQure NV (QURE) closed down -$2.10 after Thursday’s +$3,68, Wednesday’s +$2.05, Tuesday’s +$5.01 and last Monday’s -$2.01 with a positive +$0.70 or +1.14% pre-open

CRISPR Therapeutics (CRSP) closed down -$1.85 after Thursday’s -$1.86, Wednesday’s +$6.16, Tuesday’s +$0.43 and last Monday’s +$2.45 with a positive +$1.00 or +1.37% pre-open

Beam Therapeutics (BEAM) closed -$1.55 after Thursday’s +$0.87, Wednesday’s +$1.87 after Tuesday’s -$0.76 and Monday’s +$0.14 with a positive +$0.83 or +3.15% pre-open

Regenxbio (RGNX) closed down -$1.25 with a positive +$0.70 or +6.41% pre-open

Sarepta Therapeutics (SRPT) closed down -$1.02 after Thursday’s -$0.25 with a positive +$0.34 or +1.54% pre-open

 

The BOTTOM LINE: I can’t seem to let go of this quote, “It’s always darkest before the pitch dark”

The shutdown entered its 13th day on Monday, with lawmakers still unable to agree on a funding bill.

The Bureau of Labor Statistics has recalled some staff to prepare the CPI report before the Oct. 28-29 Federal Reserve policy meeting. The September CPI also is needed to determine the annual cost of living increase for Social Security.

Welcome to my world of defining the “grey’ in our universe!

  • I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

October: understand the new “flow” …

Last week:

  • 10/10 - Friday closed negative with 3 positive, 37 negative and 0 flat
  • 10/9 - Thursday closed positive with 21 positive, 19 negative and 0 flat
  • 10/8 – Wednesday closed positive with 29 positive, 10 negative and 1 flat
  • 10/7 – Tuesday closed negative with 15 positive, 25 negative and 0 flat
  • 10/6 – Monday closed negative with 17 positive, 22 negative and 1 flat

The start of October:

  • 10/3 – Friday closed positive with 27 positive, 10 negative and 3 flats
  • 10/2 – Thursday closed positive with 26 positive, 13 negative and 1 flat
  • 10/1 – Wednesday closed positive with 26 positive, 14 negative and 0 flat

Q3 Earnings are in the front-view mirror; we are about to start again …!

 

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC):

The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.