RMi pre-open: Lull

October 16, 2025 7:43am

Trading, get it right or maybe wrong; does a hold fulfill a reward in this period with significant intraday swings

As I have written, “when dramatic upsides occur, investors are often unsure exactly what to do, but they frequently act as if they do know the best path forward – don’t be LULLED into an uncertainty position!”

Sector Q3 earnings begin with IQV Holdings (IQV) on 10/28, MiMedx (MDXG) Ionis Pharmaceuticals IONS), AxoGen AXGN) on 10/29 with Moderna (MRNA) on 11/6

Pre-open Signals: 4 Positive and 3 Negative Indications

If you understand the possibilities, the inevitable is easier to maneuver

Never leave an investor uninformed … I say what others won’t, so you can do what others can’t!

Wednesday night’s … RMi Closing Bell: Shaping the narrative … https://www.regmedinvestors.com/articles/14151

Remember that overnight and pre-open actions’ futures and markets doesn’t necessarily translate into actual trading in today’s market session.

RMi Research Note: Harvard Apparatus GT (OTCQB): Who is wasting lipstick on this pig? … https://www.regmedinvestors.com/articles/13812

Thursday: The pre-open Dow futures are UP +0.28% or (+130 points), the S&P futures are UP +0.43% or (+28 points) and the Nasdaq futures are  UP +0.61% or (+152 points)

• U.S. stock futures were higher Thursday, 10/16
• European stocks were higher,
• Asia-Pacific markets rose.

Henry’omics: We need to more than consider the markets …environment to comprehend the micro re “our” universe of cell and gene therapy companies

• Wednesday: The Dow closed DOWN -17.15 points or -0.04%, the S&P closed UP +26.75 points or +0.40% while the Nasdaq closed UP +148.379 points or +0.66%
• Tuesday: The Dow closed UP +202.88 points or +0.44%, the S&P closed DOWN -10.41 points or -0.16% while the Nasdaq closed DOWN -172.907 points or -0.76%
• Monday: The Dow closed UP +587.98 points or +1.29%, the S&P closed UP +102.21 points or +1.56% while the Nasdaq closed UP +490.178 points or +2.21%
• Last week: the Dow was down -2%, the S&P down -1% and the Nasdaq +1%,
• The previous week, the Dow was up +1.3%, the S&P 500 +1.1% while the Nasdaq lost -1.3%
• Last month and Q3’s numbers, the S&P 500 Q was up +7% and the month -4.2%, the Nasdaq’s Q is up +11% and the month +5% while the Dow’s Q is up +5% and the month +1%

Q4 – 1 neutral, 7 positive and 3 negative closes

• Q3 – September, 1 holiday, 9 negative and 12 positive closes; August - 11 negative and 9 positive closes; July – 1 market holiday, 13 positive and 9 negative closes

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

• October began with a government shutdown and much fewer econs… along with the usual ups, downs
• Now uncertainty rules

Although:

uniQure NV (QURE) closed up +$3.87 after Tuesday -$3.06 after Monday’s +$0.57 with a positive +$0.97 or +1.54% pre-open

Lenz Therapeutics (LENZ) closed up +$3.05 with a positive +$2.15 or +5.14% pre-open

Moderna (MRNA) closed up +$1.47 with a positive +$0.18 or +0.65% pre-open

Beam Therapeutics (BEAM) closed up +$1.77 with a negative -$0.19 or -0.70% pre-open

BioNTech (BNTX) closed up +$1.73 with a negative -$0.17 or -0.16% pre-open

Vertex (VRTX0 closed down -$4.32 after Tuesday’s +$4.85 after Monday +$0.42 with a negative -$0.54 or -0.13% pre-open

IQV Holdings (IQV) closed down -$1.64 after Tuesday’s +$0.87 after Monday +$5.60 with a positive +$0.23 or +0.234% pre-open

Rocket Therapeutics (RCKT) with a negative -$0.03 after Tuesday’s +$0.80 with a negative -$0.03 or -0.71% pre-open

The BOTTOM LINE: I am staying with my mantra …

“It’s always darkest before the pitch dark”

The shutdown enters its 16^th day on Thursday, with lawmakers still unable to agree on a funding bill.

The stock market rally had another volatile session, jumping at Wednesday's open on strong earnings reactions, but the major indexes gave up those gains before closing mixed.

• The Dow lost a fraction in Wednesday's stock market trading.
• The S&P 500 index gained 0.4%.
• The Nasdaq composite rose 0.7%.
• The major indexes continue to be within last Friday's range.
• The small-cap Russell 2000 climbed 1%, hitting a new high, as overall advancers once again led decliners.

The Bureau of Labor Statistics has recalled some staff to prepare the CPI report before the Oct. 28-29 Fed policy meeting. The September CPI also is needed to determine the annual cost of living increase for Social Security.

Welcome to my world of defining the “grey’ in our universe!

• I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

October: understand the new “flow” …

Current week:

• 10/15 - Wednesday closed positive with 31 positive, 9 negative and 1 flat
• 10/14 - Tuesday closed positive with 28 positive, 12 negative and 0 flat
• 10/13 – Monday closed neutral with 20 positive, 20 negative and 0 flat

Last week:

• 10/10 - Friday closed negative with 3 positive, 37 negative and 0 flat
• 10/9 - Thursday closed positive with 21 positive, 19 negative and 0 flat
• 10/8 – Wednesday closed positive with 29 positive, 10 negative and 1 flat
• 10/7 – Tuesday closed negative with 15 positive, 25 negative and 0 flat
• 10/6 – Monday closed negative with 17 positive, 22 negative and 1 flat

The start of October:

• 10/3 – Friday closed positive with 27 positive, 10 negative and 3 flats
• 10/2 – Thursday closed positive with 26 positive, 13 negative and 1 flat
• 10/1 – Wednesday closed positive with 26 positive, 14 negative and 0 flat

Q3 Earnings are in the front-view mirror; we are about to start again …!

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC):

The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.