October 20, 2025 7:37am

Institutions are reeling from the downside slippage, hoping to blitz the upside from the retail investor to buy yet another dip

The shutdown enters its 20th day today, with lawmakers still unable to agree on a funding bill

Pre-open Signals: 8 Positive Indications

Never leave an investor uninformed … I say what others won’t, so you can do what others can’t!

Remember that overnight and pre-open actions’ futures and markets doesn’t necessarily translate into actual trading in today’s market session.

Friday night’s … RMi Closing Bell: Wobbling … https://www.regmedinvestors.com/articles/14155

The shutdown has slammed the brakes on crucial inflation and jobs data key to the Fed's decision making; but the Bureau of Labor Statistics is set to release September's Consumer Price Index, on Friday after a delay of more than a week.

 

Monday: The pre-open Dow futures are UP +0.18% or (+82 points), the S&P futures are UP +0.29% or (+19 points) and the Nasdaq futures are UP +0.38% or (+94 points)

  • Stock futures moved higher, yet still vibrating on Monday, 10/20
  • European markets start the week higher,
  • Asia-Pacific markets were also higher.

 

Henry’omics: We need to more than consider the markets …environment to comprehend the micro re “our” universe of cell and gene therapy companies

  • Friday: The Dow closed UP +238.37 points or +0.52%, the S&P closed UP +34.94 points or +0.53% while the Nasdaq closed UP +117.437 points or +0.52%
  • Thursday: The Dow closed DOWN -301.07 points or -0.65%, the S&P closed DOWN -41.99 points or -0.63% while the Nasdaq closed DOWN -107.542 points or -0.47%
  • Wednesday: The Dow closed DOWN -17.15 points or -0.04%, the S&P closed UP +26.75 points or +0.40% while the Nasdaq closed UP +148.379 points or +0.66%
  • Tuesday: The Dow closed UP +202.88 points or +0.44%, the S&P closed DOWN -10.41 points or -0.16% while the Nasdaq closed DOWN -172.907 points or -0.76%
  • Monday: The Dow closed UP +587.98 points or +1.29%, the S&P closed UP +102.21 points or +1.56% while the Nasdaq closed UP +490.178 points or +2.21%
  • Last week: the S&P 500 is up +1.7%, the Dow added +1.6% week to date, while the Nasdaq gained +2.1%.
  • Ther previous week: the Dow was down -2%, the S&P down -1% and the Nasdaq +1%,
  • Last month and Q3’s numbers, the S&P 500 Q was up +7% and the month -4.2%, the Nasdaq’s Q is up +11% and the month +5% while the Dow’s Q is up +5% and the month +1%

 

Q4 – 1 neutral, 7 positive and 5 negative closes

  • Q3 – September, 1 holiday, 9 negative and 12 positive closes; August - 11 negative and 9 positive closes; July – 1 market holiday, 13 positive and 9 negative closes

 

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

  • October began with a government shutdown and much fewer econs… along with the usual ups, downs
  • Now uncertainty rules

Although:

Vertex (VRTX) closed up +$8.20 after Thursday +$0.71 after Wednesday’s -$4.32, Tuesday’s +$4.85 and Monday +$0.42 with a positive +$0.22 or +0.05% pre-open

CRISPR Therapeutics (CRSP) closed up +$0.72 after Thursday -$7.39 after Wednesday’s +$2.44, Tuesday +$1.09 and Monday -$4.81 with a positive +$1.25 or +1.81% pre-open

Alnylam Pharmaceuticals (ALNY +$0.60 after Thursday +$10.8 with a positive +$3.13 or +0.65% pre-open

Precigen (PGEN) closed up +$0.51 with a positive +$0.03 or +0.75% pre-open

Supernus Therapeutics (SUPN) closed up +$0.41 with a positive +$0.12 or +0.24%

Lenz Therapeutics (LENZ) closed down -$2.19 after Thursday’s -$1.40 and Wednesday’s +$3.05 with a positive +$0.74 or +1.93% pre-open

uniQure NV (QURE) closed down -$1.99 after Thursday’s -$2.84, Wednesday’s +$3.87, Tuesday -$3.06 and Monday’s +$0.57 with a positive +$1.90 or +3.28% pre-open

Moderna (MRNA) closed down -$1.13 after Thursday’s -$0.58, Wednesday’s +$1.47 and Tuesday -$0.49 with a positive +$0.50 or +1.92% pre-open

 

The BOTTOM LINE: I’m opening with another mantra … If you understand the probabilities, the inevitable is easier to maneuver

Welcome to my world of defining the “grey’ in our universe!

  • I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

 

October: understand the new “flow” …

Last week:

  • 10/17 - Friday closed negative with 11 positive, 28 negative and 1 flat
  • 10/16 - Thursday closed negative with 17 positive, 22 negative and 1 flat
  • 10/15 - Wednesday closed positive with 31 positive, 9 negative and 1 flat
  • 10/14 - Tuesday closed positive with 28 positive, 12 negative and 0 flat
  • 10/13 – Monday closed neutral with 20 positive, 20 negative and 0 flat

The previous week:

  • 10/10 - Friday closed negative with 3 positive, 37 negative and 0 flat
  • 10/9 - Thursday closed positive with 21 positive, 19 negative and 0 flat
  • 10/8 – Wednesday closed positive with 29 positive, 10 negative and 1 flat
  • 10/7 – Tuesday closed negative with 15 positive, 25 negative and 0 flat
  • 10/6 – Monday closed negative with 17 positive, 22 negative and 1 flat

The start of October:

  • 10/3 – Friday closed positive with 27 positive, 10 negative and 3 flats
  • 10/2 – Thursday closed positive with 26 positive, 13 negative and 1 flat
  • 10/1 – Wednesday closed positive with 26 positive, 14 negative and 0 flat

Q3 Earnings are in the front-view mirror; we are about to start again …!

  • Sector Q3 earnings begin with IQV Holdings (IQV) on 10/28, MiMedx (MDXG) Ionis Pharmaceuticals IONS), AxoGen AXGN) on 10/29 with Moderna (MRNA) on 11/6

 

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC):

The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.