RMi pre-open: CPI

October 24, 2025 8:11am

CPI reports, annual inflation rate hit 3.0% in September, lower than expected of 3.1%.

Econs have usually created havoc in the sector’s share pricing, maybe not?

Pre-open Signals: 10 Positive and 2 Negative Indications

Never leave an investor uninformed … I say what others won’t, so you can do what others can’t!

TGIF

Remember that overnight and pre-open actions’ futures and markets doesn’t necessarily translate into actual trading in today’s market session.

Thursday night’s … RMi Closing Bell: Another negative … https://www.regmedinvestors.com/articles/14163

I make a commitment to provide need-to-know “facts in evidence” as an equity’s volatility is one tactical signal for stocks. My thesis is important in trying to distinguish the temporary from real pricing digression or progress.

Friday: The pre-open Dow futures are UP +0.15% or (+71 points), the S&P futures are UP +0.31% or (+21 points) and the Nasdaq futures are UP +0.47% or (+119 points)

• Stock futures rose early Friday, 10/24 ahead of a key inflation data,
• European stocks were lower,
• Asia Pacific markets were mixed

Henry’omics: We need to more than consider the market’s setting to grasp the micro re “our” universe of cell and gene therapy companies

• Thursday: The Dow closed UP +144.20 points or +0.31%, the S&P closed UP +39.04 points or +0.58% while the Nasdaq closed UP +201.402 points or +0.89%
• Wednesday: The Dow closed DOWN -334.33 points or -0.71%, the S&P closed DOWN -35.94 points or -0.53% while the Nasdaq closed DOWN -213.27 points or -0.93%
• Tuesday: The Dow closed UP +218.16 points or +0.47%, the S&P closed UP +0.22 points or +0.00% while the Nasdaq closed DOWN -36.877 points or -0.16%
• Monday: The Dow closed UP +515.97 points or +1.12%, the S&P closed UP +71.12 points or +1.07% while the Nasdaq closed UP +310.568 points or +1.37%
• Last week: the S&P 500 is up +1.7%, the Dow added +1.6% and the Nasdaq+2.1%.
• Ther previous week: the Dow was down -2%, the S&P down -1% and the Nasdaq +1%,
• Last month and Q3’s numbers, the S&P 500 Q was up +7% and the month -4.2%, the Nasdaq’s Q is up +11% and the month +5% while the Dow’s Q is up +5% and the month +1%

Economic Data Docket:

• The September consumer price index report …
• Economists expect the CPI for September came in at a 3.1% annual rate, or 0.2 percentage point higher than the August level, per Dow Jones estimates. Excluding food and energy, core CPI is projected to show a 3.1% annual rate, the same as August.

Q4 – 1 neutral, 8 positive and 8 negative closes

• Q3 – September, 1 holiday, 9 negative and 12 positive closes; August - 11 negative and 9 positive closes; July – 1 market holiday, 13 positive and 9 negative closes

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

• October began with a government shutdown and much fewer econs… along with the usual ups, downs
• Now uncertainty rules

Info:

IQV Holdings (IQV) closed up +$1.99 with a positive +$0.10 or +0.05% pre-open

Supernus Therapeutics (SUPN) closed up +$1.35 with a positive +$0.08 or +0.15% pre-open

Intellia Therapeutics (NTLA) closed up +$1.31 after Wednesday’s -$2.39, Tuesday’s -$1.01 and Monday’s +$3.23 with a positive +$0.31n or +1.20% pre-open

BioLife Solutions (BLFS) closed up +$1.12 with a positive +$0.25 or +0.97% pre-open

CRISPR Therapeutics (CRSP +$0.49 after Wednesday’s -$5.80, Tuesday’s -$1.65 and Monday’s +$4.82 with a positive +$0.89 or +1.32% pre-open

Regenxbio (RGNX) closed up +$0.39 after Wednesday’s -$0.90 and Tuesday’s +$0.45 with a positive +$0.95 or +7.55% pre-open

Vertex (VRTX) closed down -$3.81 after Wednesday’s -$0.17 after Tuesday’s +$7.17 and Monday’s +$2.29 with a positive +$0.57 or +0.13% pre-open

BioNTech (BNTX) closed down -$1.48 with a negative -$0.07 or -0.07% pre-open

Lenz Therapeutics (LENZ) closed down -$1.32 after Wednesday’s -$0.86, Tuesday’s -$2.75 and Monday’s -$1.95 with positive +$1.09 or +3.47% pre-open

uniQure NV (QURE) closed down -$0.58 after Wednesday’s -$3.16, Tuesday’s -$0.85 and Monday’s +$5.92 with a positive +$0.75 or +1.26% pre-open

Vericel (VCEL) closed down -$0.44 with a positive +$0.06 or +0.17% pre-open

Arrowhead Pharma (ARWR) closed down -$0.28 with a negative -$0.14 or -0.37% pre-open

The BOTTOM LINE: I’m opening with another mantra. “If you understand probabilities, the inevitable is easier to maneuver” …

• READY for a bounce ,... UP?

The shutdown enters its 24^nd day today, with lawmakers still unable to agree on a funding bill … as Democrats block the 12^th negotiation

• The shutdown has also slammed the brakes on crucial inflation and jobs data key to the Fed's decision making; but the Bureau of Labor Statistics is set to release September's Consumer Price Index, on Friday after a delay of more than a week.

Welcome to my world of defining the “grey’ in our universe!

• “I hate to be so negative or contrarian but, this is a NO spin zone and truth is its product; I can always be WRONG but, I am mostly EARLY!”
• I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

October: understand the new “flow” …

New week:

• 10/23 – Thursday closed negative with 15 negative, 22 negative and 3 flats
• 10/22 – Wednesday closed negative with 4 positive, 34 negative and 2 flat
• 10/21 - Tuesday closed negative with 17 positive, 23 negative and 0 flat
• 10/20 - Monday closed positive with 34 positive, 4 negative and 2 flats

Last week:

• 10/17 - Friday closed negative with 11 positive, 28 negative and 1 flat
• 10/16 - Thursday closed negative with 17 positive, 22 negative and 1 flat
• 10/15 - Wednesday closed positive with 31 positive, 9 negative and 1 flat
• 10/14 - Tuesday closed positive with 28 positive, 12 negative and 0 flat
• 10/13 – Monday closed neutral with 20 positive, 20 negative and 0 flat

Q3 Earnings are in the front-view mirror; we are about to start again …!

• Sector Q3 earnings begin with IQV Holdings (IQV) on 10/28, MiMedx (MDXG) Ionis Pharmaceuticals IONS), AxoGen AXGN) on 10/29 with Moderna (MRNA) on 11/6

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC):

The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.