RMi pre-open: A friendlier week and market?

November 10, 2025 7:55am

Answering a question with a question; hope for a re-opening to end the shutdown which has continued 40 days, 6th weeks after 15 Democratic has voted NOT to reopen, becoming the longest in American history?

No one likes counting: 8 negative closes in the last 10 sessions with another week of earnings = positive moves

News: Intellia Therapeutics (NTLA -$2.80 or -22.73% to $9.52 with a +0.91 Monday pre-open) stock crashed Friday, adding to 2 weeks of setbacks after a patient in its gene-editing study died following serious increases in liver enzymes. NTLA was testing its gene-editing process, nex-z, in patients with transthyretin amyloidosis with cardiomyopathy and polyneuropathy. In this condition, abnormal protein called transthyretin builds up on the heart and nerves, causing complications.  NTLA had stopped dosing patients in the final-phase study after the patient was hospitalized.

Earnings this week: uniQure NV (QURE) and Capricor Therapeutics (CAPR) on 11/10, Precigen (PGEN) on 11/13

Pre-open Signals: 2 Negative and 6 Positive Indications

Never leave an investor uninformed … I say what others won’t, so you can do what others can’t!

“I hate to be considered negative or contrarian but, this is a NO spin zone and truth is its product; I can always be WRONG but, I am mostly EARLY!”

Friday’s RMi Closing Bell: Watching … https://www.regmedinvestors.com/articles/14187   

Remember that overnight and pre-open actions’ futures and markets doesn’t necessarily translate into actual trading in today’s market session.

Monday: The pre-open Dow futures are UP +0.39% or (+183 points), the S&P futures are UP +0.89% or (+60 points) and the Nasdaq futures are UP +1.41% or (+354 points)

• Stock futures elevate after shutdown is/could end; Monsay, 11/10
• European markets rallied
• Asia Pacific markets jumped

Henry’omics: We need to more than consider the market’s setting to grasp the micro re “our” universe of cell and gene therapy companies

• Friday: The Dow closed UP +74.80 points or +0.16%, the S&P closed UP +8.48 points or +0.13% while the Nasdaq closed DOWN -49.455 points or -0.22%
• Thursday: The Dow closed DOWN -398.70 points or -0.84%, the S&P closed DOWN -75.97 points or -1.12% while the Nasdaq closed DOWN -445.805 points or -1.90%
• Wednesday: The Dow closed UP +225.86 points or +0.48%, the S&P closed UP +24.74 points or +0.37% while the Nasdaq closed UP +151.16 points or +0.65%
• Tuesday: The Dow closed DOWN -251.07 points or -0.53%, the S&P closed DOWN -80.30 points or -1.17% while the Nasdaq closed DOWN -486.087 points or -2.04%
• Monday: The Dow closed DOWN -226.19 points or -0.48%, the S&P closed UP +11.77 points or +0.17% while the Nasdaq closed UP +109,766 points or +0.46%

• Last week: The S&P 500 was down -1.7%, the Dow -1.3% and the Nasdaq -3%
• The previous week: The S&P 500 was up 1.5%, the Dow +0.9% and the Nasdaq is up +3.2%
• Last month: the S&P 500 was up +2.3%, the Nasdaq’s +4.7% and the Dow’s is up +2.5%.

Economic Data Docket:

• A light week for investors on the data front. The National Federation of Independent Business's small business optimism index and mortgage application data from the Mortgage Bankers Association will lead the stretch.

Q4 – November, 1 positive and 4 negative sessions

• October, 1 neutral, 10 positive and 12 negative closes

• Q3 – September, 1 holiday, 9 negative and 12 positive closes; August - 11 negative and 9 positive closes; July – 1 market holiday, 13 positive and 9 negative closes

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

uniQure NV (QURE) closed up +$0.28 after Thursday’s +$1.45, Wednesday’s -$4.38, Tuesday’s -$3.85 and Monday’s -$33.40 with a negative -$1.79 or -6.44% pre-open

Moderna (MRNA) closed up +$0.21 after Thursday’s +$0.77, Wednesday’s -$0.19, Tuesday’s -$1.16 and Monday’s -$2.25 with a positive +$0.12 or +0.49%, pre-open

Vericel (VCEL) closed up +$0.19 after Thursday’s +$1.55 and Wednesday’s +$0.95 with a positive +$0.14 or +0.36% pre-open

Vertex (VRTX) closed down -$6.78 after Thursday’s -$0.75, Wednesday’s -$4.67, Tuesday’s -$4.33 and Monday’s +$0.43 with a positive +$3.55 or +0.87% pre-open

CRISPR Therapeutics (CRSP) closed down -$1.49 with a positive +$3.36 or +6.10% pre-open

Intellia Therapeutics (NTLA) closed down -$2.80 with a positive +$0.91 or +9.56% pre-open

Ionis Pharmaceuticals (IONS) closed down -$0.55 after Thursday’s -$0.58 and Wednesday’s +$1.80 with a negative -$9.45 or -12,85% pre-open

IQVIA Holdings (IQV -$0.41 after Thursday’s+$0.74, Wednesday’s -$0.86, Tuesday’s -$2.84 and Monday’s -$2.46 with a positive +$1.35 or +0.64% pre-open

The BOTTOM LINE: Still feeling the drag…

The 6^th trading day of November began with a positive hope

I got on my computer/laptop/ my horse with a lantern as I ride yelling … “earnings are here, earnings are here”!

• Q3 Earnings coming: Arrowhead Pharma (ARWR) FY25 results on 11/25

Expect earnings’ results that meet, beat or miss revenue estimates, EPS as to pricing expectations, consensus … sector earnings while LPS (loss-per-share) assumes adjustments

Welcome to my world of defining the “grey’ in our universe!

• As the leading voice of cell and gene therapy investors; I am NOT always a doom and gloom analyst/journalist but a man who has been “there” (BUY, SELL, VC and multiple operating roles) with the gray hair and a readership following with real numbers to prove it!
• I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

November to understand the flow review some of October:

New week and month, November:

• 11/7 – Friday closed negative with 16 positive, 24 negative and 0 flat
• 11/6 – Thursday closed negative with 15 positive, 24 negative and 1 flat
• 11/5 - Wednesday closed positive with 20 positive, 18 negative and 2 flats
• 11/4 – Tuesday closed negative with 10 positive, 30 negative and 0 flat
• 11/3 – Monday closed negative with 10 positive, 26 negative and 4 flats

Last week:

• 10/31 – Friday closed positive with 28 positive, 11 negative and 1 flat
• 10/30 – Thursday closed negative with 13 positive, 25 negative and 2 flats
• 10/29 - Wednesday closed negative with 9 positive, 30 negative and 1 flat
• 10/28 -Tuesday closed negative with 16 positive, 21 negative and 3 flats
• 10/27- Monday closed negative with 18 positive, 22 negative and 0 flats

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC):

The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.