November 12, 2025 7:03am

An appearance/semblance of market breath

Shutdown reopening path remains foggy before House-wide vote

Pre-open Signals: 4 Positive Indications and a lot of drops

Never leave an investor uninformed … I say what others won’t, so you can do what others can’t!

“I hate to be considered negative or contrarian but, this is a NO spin zone and facts are its product; I can always be WRONG but, I am mostly EARLY!”

RMi Research Note: Harvard Apparatus GT (OTCQB): Broke … https://www.regmedinvestors.com/articles/13812

RMi Closing: Optimism … https://www.regmedinvestors.com/articles/14191

Remember that overnight and pre-open actions’ futures and markets doesn’t necessarily translate into actual trading in today’s market session.

 

Wednesday: The pre-open Dow futures are UP +0.15% or (+69 points), the S&P futures are UP +0.25% or (+17 points) and the Nasdaq futures are UP +0.45% or (+114 points)

  • Stock futures were up and positive on Wednesday, 11/12
  • European markets were higher
  • Asia Pacific markets mostly rose although Australia was down

 

Henry’omics: We need to more than consider the market’s setting to grasp the micro re “our” universe of cell and gene therapy companies

  • Tuesday: The Dow closed UP +559.33 points or +1.18%, the S&P closed UP +14.18 points or +0.21% while the Nasdaq closed DOWN -58.874 points or -0.25%
  • Monday: The Dow closed UP +381.53 points or +0.81%, the S&P closed UP +103.63 points or +1.54% while the Nasdaq closed UP +522.637 points or +2.27%
  • Last week: The S&P 500 was down -1.7%, the Dow -1.3% and the Nasdaq -3%
  • The previous week: The S&P 500 was up 1.5%, the Dow +0.9% and the Nasdaq is up +3.2%
  • Last month: the S&P 500 was up +2.3%, the Nasdaq’s +4.7% and the Dow’s is up +2.5%.

 

Q4 – November, 3 positive and 4 negative sessions

  • October, 1 neutral, 10 positive and 12 negative closes

 

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

Today's version this a.m.

Vertex (VRTX) closed up +$4.86 after Monday’s +$11.73 with a positive +$0.45 or +0.10% pre-open

uniQure NV (QURE) closed up +$4.57 with a positive +$1.02 or +3.31% pre-open

Lenz Therapeutics (LENZ) closed up +$3.26 with a positive +$0.73 or +2.76% pre-open

Arrowhead Pharma (ARWR) closed up +$1.65 after Monday’s +$0.62 with a positive +$0.50 or +1.20% pre-open

 

The BOTTOM LINE: Get some ... profits to cash in!

The 8th trading session of November followed a positive close.

I got on my computer/laptop/ my horse with a lantern as I ride yelling … “earnings are here, earnings are here”!

  • Q3 Earnings coming: Arrowhead Pharma (ARWR) FY25 results on 11/25

Expect earnings’ results that meet, beat or miss revenue estimates, EPS as to pricing expectations, consensus … sector earnings while LPS (loss-per-share) assumes adjustments

Welcome to my world of defining the “grey’ in our universe!

  • As the leading voice of cell and gene therapy investors; I am NOT always a doom and gloom analyst/journalist but a man who has been “there” (BUY, SELL, VC and multiple operating roles) with the gray hair and a readership following with real numbers to prove it!
  • I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

November to understand the flow:

This week:

  • 11/11 – Tuesday closed positive with 34 positive, 4 negative and 2 flats
  • 11/10 - Monday closed positive with 26 positive, 14 negative and 0 flats

Last week:

  • 11/7 – Friday closed negative with 16 positive, 24 negative and 0 flat
  • 11/6 – Thursday closed negative with 15 positive, 24 negative and 1 flat
  • 11/5 - Wednesday closed positive with 20 positive, 18 negative and 2 flats
  • 11/4 – Tuesday closed negative with 10 positive, 30 negative and 0 flat
  • 11/3 – Monday closed negative with 10 positive, 26 negative and 4 flats

 

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC):

The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.