November 28, 2025 3:01pm

Now it’s about December’s tax selling and rotations

The C&GT sector closed positive again while the CBOE Fear (VIX) index closed at 16.35 after Thursday’s holiday, Wednesday at 17.15, Tuesday’s 18.56 and Monday’s 20.52

RMi collects, curates, interprets and disseminates cell and gene therapy sector (C&GT) fact-based news, trusted and verified intel and share pricing data to bridge the gap to an investment decision

It’s not always time to buy or sell; but it is time to KNOW and why!

Never leave an investor uninformed! 

TGIF

RMi Pre-opening Bell: None, recovering “turkey’holic”; it was the dishes and the pans that did me with a barely sip of wine!

RMi Research Note: Harvard Apparatus GT (OTCQB): Broke … https://www.regmedinvestors.com/articles/13812

The peril facing the cell and gene therapy (C&GT) sector’s share pricing isn’t just applications of macro or even micro econs, sentiment or algorithms within electronic trading; it’s losing highly reliable, accurate and transparent data.

 

A shortened trading day, ended at 1 p.m. ET; while the bond market closed at 2 p.m. ET today.

Friday: The Dow closed UP +289.30 points or +0.61%, the S&P closed UP +36.48 points or +0.54% while the Nasdaq closed UP +150.996 points or +0.65%

  • Theme of the session: shortened, early close, thin volume and a bit more of a risk-on sentiment

Friday’s (my) 40-company covered sector’s advance/decline line opened positive with 23 incliners, 15 decliners and 2 flats ending with a positive close of 29 incliners, 10 decliners and 1 flat

  • A pullback in tech stocks have weighed on the major averages this month, as doubt swirled around the future profitability of AI companies. The Nasdaq fell almost 2% on the month, on track to end a 7-month advance. The S&P 500 and Dow were slightly higher, thanks to this week’s gains. <CNBC>

Henry’omics: We need to more than consider the macro-economic environment to comprehend the micro re “our” universe of cell and gene therapy (C&GT) sector

  • The Dow is on pace to finish the weekly period up more than 3%. The S&P 500 is also higher by more than 3%, while the Nasdaq has jumped more than 4%.
  • The S&P 500 has shed 0.1%, while the Nasdaq has fallen nearly 2% and the Dow is up 0.3%.

Metrics:  Friday …

  • The RUT was up +14.32 points or +0.58%,
  • The XLV was down -0.77 points or -0.49%,
  • The NBI was up +4.47 points or +0.08%;
  • The XBI was up +0.31 points or +0.25%
  • The IWM was up +1.45 or +0.59%;
  • The IBB was down - points or -%,
  • The VIX was down -0.86 points or -5%  at to 16.35

 

Q4 – November – 1 holiday, 8 positive and 11 negative closes

  • October -1 neutral, 11 positive and 12 negative closes

 

Friday Closing UP (10 of 29)

  • Alnylam Pharmaceuticals (ALNY +$6.11 after Thursday’s holiday, Wednesday’s +$15.32, Tuesday’s -$4.43 and Monday’s -$2.15),
  • Vertex (VRTX +$1.44 after Thursday’s holiday, Wednesday’s +$2.35, Tuesday’s +$5.82 and Monday’s -$2.76),
  • Ultragenyx Pharmaceuticals (RARE +$0.99),
  • Moderna (MRNA +$0.97),
  • Intellia Therapeutics (NTLA +$0.47 after Thursday’s holiday and Wednesday’s -$0.03),
  • BioNTech (BNTX +$0.45 after Thursday’s holiday, Wednesday’s +$2.99, Tuesday’s +$317 and Monday’s +$0.95),
  • Compass Therapeutics (CMPX +$0.41 after Thursday’s holiday and Wednesday’s +$0.38)
  • Sarepta Therapeutics (SRPT +$0.39),
  • Beam Therapeutics (BEAM +$0.30),
  • Entrada Therapeutics (TRDA +$0.19 after Thursday’s holiday and Wednesday’s -$0.04),

Flat (1)

  • MiMedx (MDXG)

Friday’s Closing DOWN (10 of 10): -$ after Thursday’s holiday and Wednesday’s

  • Arrowhead Pharma (ARWR -$5.01 after Thursday’s holiday, Wednesday’s +$10.92, Tuesday’s +$2.53 and Monday’s +$3.81),
  • IQVIA Holdings (IQV -$1.79 after Thursday’s holiday, Wednesday’s -$0.02, Tuesday’s +$3,61 and Monday’s+$3.28),
  • Supernus Therapeutics (SUPN -$0.67),
  • Lenz Therapeutics (LENZ -$0.20 after Thursday’s holiday, Wednesday’s +$0.84 after Tuesday’s +$2.06),
  • BioLife Solutions (BLFS -$0.18 after Thursday’s holiday and Wednesday’s -$0.31),
  • Mesoblast (MESO -$0.14),
  • Vericel (VCEL -$0.12 after Thursday’s holiday, Wednesday’s -$2.17, Tuesday’s +$3.66 and Monday’s -$0.70),
  • uniQure NV (QURE -$0.12 after Thursday’s holiday and Wednesday’s -$0.33),
  • Adverum Biotechnologies (ADVM -$0.04),
  • Sangamo Therapeutics (SGMO -$0.0031)

 

The Bottom Line: More of the … WHYs

Indexes moved higher (5th straight advance after a market holiday) on Friday, on the last day of trading of November as the “Street” stays upbeat on an interest-rate cut next month.

  • Indexes popped with weekly gains as traders wrapped up a volatile November.
  • Fears faded over an artificial intelligence bubble as well as concerns that the Fed might hold off on more rate cuts following a delayed September jobs report.
  • Small caps on the Russell 2000 climbed 0.3%. Markets did a half day of trading on Friday, with the stock market closing at 1 p.m. ET.

As the leading voice of cell and gene therapy investors; I am NOT always a doom and gloom analyst/journalist but a man who has been “there” (BUY, SELL, VC and multiple operating roles) with the gray hair and a readership following with real numbers to prove it!

A real question, are cell and gene therapy (C&GT) sector companies with high insider ownership present … opportunity?

  • Do they often demonstrate alignment between management and shareholder interests … a critical factor in navigating volatile market conditions?
  • I will be looking into this …! Stay tuned.

 

November's end: understand the “flow” …

This week:

  • 11/28 - Friday closed positive with 29 positive, 10 negative and 1 flat
  • 11/27 – Thursday, a market holiday
  • 11/26 – Wednesday closed positive with 28 positive, 12 negative and 0 flat
  • 11/25 – Tuesday closed positive with 24 positive, 15 negative and 1 flat
  • 11/24 - Monday closed positive with 25 positive, 14 negative and 1 flat

Last week:

  • 11/21 - Friday closed positive with 30 positive, 9 negative and 1 flat
  • 11/20 – Thursday closed negative with 8 positive, 31 negative and 1 flat
  • 11/19 – Wednesday closed negative with 10 positive, 27 negative and 3 flats
  • 11/18 – Tuesday closed negative with 18 positive, 21 negative and 1 flat
  • 11/17 – Monday closed negative with 19 positive, 20 negative and 1 flat

The previous week:

  • 11/14 - Friday closed negative with 19 positive, 21 negative and 0 flats
  • 11/13 – Thursday closed negative with 8 positive, 32 negative and 0 flat
  • 11/12 – Wednesday closed negative with 18 positive, 22 negative and 0 flat
  • 11/11 – Tuesday closed positive with 34 positive, 4 negative and 2 flats
  • 11/10 - Monday closed positive with 26 positive, 14 negative and 0 flats

Beginning November:

  • 11/7 – Friday closed negative with 16 positive, 24 negative and 0 flat
  • 11/6 – Thursday closed negative with 15 positive, 24 negative and 1 flat
  • 11/5 - Wednesday closed positive with 20 positive, 18 negative and 2 flats
  • 11/4 – Tuesday closed negative with 10 positive, 30 negative and 0 flat
  • 11/3 – Monday closed negative with 10 positive, 26 negative and 4 flats

 

Welcome to my world of defining the “grey’ in our universe!

  • I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.
  • “I hate to be so negative or contrarian but, this is a NO spin zone and truth is its product; I can always be WRONG but, I am mostly EARLY!”

 

Why do I keep repeating, framed in a different para, so investors can make the connection

The top three (3) performing in the session:   

  • Friday: Alnylam Pharmaceuticals (ALNY), Vertex (VRTX) and Ultragenyx Pharmaceuticals (RARE)
  • Thursday, a market holiday
  • Wednesday: Alnylam Pharmaceuticals (ALNY), Arrowhead Pharma (ARWR) and BioNTech (BNTX)
  • Tuesday: Vertex (VRTX), Vericel (VCEL) and IQVIA Holdings (IQV)
  • Monday: Arrowhead Pharma (ARWR), IQVIA Holdings (IQV) and Ionis Therapeutics (IONS)

The worst three (3) in the session:

  • Friday: Arrowhead Pharma (ARWR), IQVIA Holdings (IQV) and Supernus Therapeutics (SUPN)
  • Thursday, a market holiday
  • Wednesday: Vericel (VCEL), BioLife Solutions (BLFS) and UniQure NV (QURE)
  • Tuesday: Alnylam Pharmaceuticals (ALNY), Lenz Therapeutics (LENZ) and Harvard Apparatus RT (OTCQB: HRGN)
  • Monday: Vertex (VRTX), Alnylam Pharmaceuticals (ALNY) and Capricor (CAPR)

 

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. Whether information or intelligence is good, bad, or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.

Henry McCusker, the editor, and publisher of RegMed Investors does not hold or have positions in securities referred to in this publication. Regulation Analyst Certification (Reg AC):

The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed in this report.