December 8, 2025 7:49am

A busy calendar this week; Fed’s Wednesday decision, past week’s S&P’s 4th session, Dow’s 9th positive session of 10, Nasdaq’s 4th winning sessions

What about investor sentiment? Exuberance can signal a crest preceding a sharp decline

Pre-open Signals: 3 Positive and 5 Negative Indications

Never leave an investor uninformed … I say what others won’t, so you can do what others can’t!

News: Arrowhead Pharmaceuticals (ARWR +$0.15 pre-open) has dosed the first subjects in a P1/2a clinical trial of ARO-MAPT, an investigational RNA interference (RNAi) therapeutic being developed as a potential treatment for tauopathies including Alzheimer’s disease, a progressive neurodegenerative disease characterized by cognitive and functional decline. Alzheimer’s disease is the most common cause of dementia, affecting an estimated 32 M people worldwide, and is part of a group of neurodegenerative diseases called tauopathies that are marked by the abnormal accumulation and formation of tau tangles in neurons.

RMi Research Note: Harvard Apparatus GT (OTCQB: HRGN): I reiterate WHO is PACKING the Pig that’s Broke … https://www.regmedinvestors.com/articles/13812

Friday’s RMi Closing Bell: Breadthless … https://www.regmedinvestors.com/articles/14219   

Remember that overnight and pre-open actions’ futures and markets doesn’t necessarily translate into actual trading in today’s market session.

 

A market timer looking to avoid the worst of the 2022 decline might have done so by moving to the sidelines as they anticipated the Federal Reserve’s moves to increase short-term rates, which began in March of that year. <MarketWatch>

Monday: The pre-open Dow futures are UP +0.05% or (+25 points), the S&P futures are UP +0.11% or (+8 points) and the Nasdaq futures are UP +0.23% or (+60 points)

  • Stock futures are up but barely, Monday, 12/8
  • European markets were mixed yet higher,
  • Asia Pacific markets traded mixed

 

Economic data reporting: None

 

Henry’omics: We need to more than consider the market’s setting to grasp the micro re “our” universe of cell and gene therapy companies

  • Friday: The Dow closed UP +104.05 points or +0.22%, the S&P closed UP +13.28 points or +0.19% while the Nasdaq closed UP +72.992 points or +0.31%
  • Thursday: The Dow closed DOWN -31.96 points or -0.07%, the S&P closed UP +7.40 points or +0.11% while the Nasdaq closed UP +51.044 points or +0.22%
  • Wednesday: The Dow closed UP +408.44 points or +0.86%, the S&P closed UP +20.35 points or +0.30% while the Nasdaq closed UP +40.417 points or +0.17%
  • Tuesday: The Dow closed UP +185.13 points or +0.39%, the S&P closed UP +16.74 points or +0.25% while the Nasdaq closed UP +137.752 points or +0.59%
  • Monday: The Dow closed DOWN -427.06 points or -0.89%, the S&P closed DOWN -36.44 points or -0.53% while the Nasdaq closed DOWN -89.763 points or -0.38%
  • Last week: The S&P 500 is up +0.3%, the Dow +0.5% and the Nasdaq is up +0.9%.
  • The previous week: The S&P 500 increased +4%. the Dow +3% and the Nasdaq jumped 1%.
  • November ended: the S&P 500 and Dow were slightly higher, as the Nasdaq fell 2%,

 

Q4 – December, 2 positive and 3 negative closes

  • November, 1 holiday, 8 positive and 11 negative sessions
  • October, 1 neutral, 10 positive and 12 negative closes

 

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

Pre-open, I take the top 10 and bottom 10 of the previous session's closes to measure the potential of the morning’s possibles ...

Moderna (MRNA +$2.21 after Thursday’s +$0.34 and Wednesday’s +$1.12 with a negative -$0.33 or -1.19% pre-open

BioNTech (BNTX) closed up +$0.25 after Thursday’s -$0.72 with a positive +$3.10 or +3.22% pre-open

Alnylam Pharmaceuticals (ALNY) closed down -$7.22 after Thursday’s -$7.71, Wednesday’s +$8.36, Tuesday’s +$10.37 and last Monday’s +$3.33 with a negative -$8.13 or -1.77% pre-open

Arrowhead Pharma (ARWR) closed down -$3.22 after Thursday’s -$0.76, Wednesday’s +$7.12, Tuesday’s +$1.70 and last Monday’s +$3.55 with a positive +$0.15 or +0.24% pre-open

Beam Therapeutics (BEAM -$1.82 after Thursday’s +$2.17, Wednesday’s +$3.37, Tuesday’s -$0.68 and last Monday’s -$1.28 with a positive +$0.81 or +2.99% pre-open

uniQure NV (QURE) closed down -$1.41 after Thursday’s -$2.39 with a negative -$0.32 or -1.50% pre-open

CRISPR Therapeutics (CRSP) closed down -$1.30 after Thursday’s +$2.19, Wednesday’s +$4.41, Tuesday’s -$0.59 and last Monday’s -$1.30 with a positive +$1.60 or +2.81% pre-open

Vericel (VCEL -$0.56 after Thursday’s -$0.67with a positive +$0.17 or +0.47% pre-open

 

The BOTTOM LINE: Still feeling the what … anxiety with a small dose/feeling of optimism!

Welcome to my world of defining the “grey’ in our universe!

  • The stock market rally continues to show strength and breadth, with the key indexes nearing record highs and a variety of leading stocks flashing buy signals but, I say a downdraft!
  • With a downside end-of-month and year rotation and rebalance, In the last of December and 2025, it means investors have to be careful of slippage targets.

Limit the risk …

Last week:

  • 12/5 – Friday closed negative with 13 positive, 26 negative and 1 flat
  • 12/4 – Thursday closed positive with 26 positive, 12 negative and 2 flats
  • 12/3 – Wednesday closed positive with 35 positive, 4 negative and 1 flat
  • 12/2 - Tuesday closed negative with 10 positive, 29 negative and 1 flat
  • 12/1 – Monday closed negative with 5 positive, 31 negative and 0 flat

The previous week, November:

  • 11/28 - Friday closed positive with 29 positive, 10 negative and 1 flat
  • 11/27 – Thursday, a market holiday
  • 11/26 – Wednesday closed positive with 28 positive, 12 negative and 0 flat
  • 11/25 – Tuesday closed positive with 24 positive, 15 negative and 1 flat
  • 11/24 - Monday closed positive with 25 positive, 14 negative and 1 flat

 

As the leading voice of cell and gene therapy investors; I am NOT always a doom and gloom analyst/journalist but a man who has been “there” (BUY, SELL, VC and multiple operating roles) with the gray hair and a readership following with real numbers to prove it!

  • I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

 

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC):

The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.