RMi Pre-opening: Too high or too fast?

December 23, 2025 8:02am

Sell into an UP sector, after 3 positive sector closes; AVOID having to sell in a down market

A holiday shortened week, US stock markets will shut early on Wednesday for the Christmas Eve start of holidays, and will be closed all of Thursday for Christmas Day

Didn’t forget econs ... Gross domestic product (GDP) increased at a ‌4.3% annualized rate last quarter, in its initial estimate of Q3 GDP. The economy grew at a 3.8% pace in Q2. Economists had forecast GDP would rise at a 3.3% pace. Consumer spending increased at a 3.5% rate Q3 after advancing at a 2.5% ⁠pace in Q2.

As I have written; “It’s been a good clue to be reducing “some” exposures, exiting some also-rans or questionable data delays”

Never leave retail investor uninformed … I say what others won’t, so you can do what others can’t! 

Think of “our” universe as a game of shuts and ladders or sometimes monopoly … and follow RMi’s “interchanges” to gain profit moves or recoup losses –  ponder ANY move before you act!

Monday’s RMi Closing Bell: Tailwinds further stimulated the witch’s broom … https://www.regmedinvestors.com/articles/14240   

RMi Research Note: Harvard Apparatus GT (OTCQB: HRGN): I reiterate WHO is pumping the volume and share pricing? … https://www.regmedinvestors.com/articles/13812   

Tuesday: The pre-open Dow futures are DOWN -0.06% or (-29  points), the S&P futures are DOWN -0.05% or (-3.5 points) and the Nasdaq futures are DOWN -0.06% or (-15 points)

• Stock futures trading down and lean, Tuesday 12/23
• European markets hit some fresh highs,
• Asia Pacific markets traded higher.

Economic Data: This week brings the release of piecemeal economic data delayed by the US shutdown.

• GDP (delayed report)     Q3                          3.2%      3.8%
• Durable-goods orders (delayed report)  Oct.                        -1.1%     0.5%
• Durable-goods minus transportation       Oct.                        --             0.6%
• Industrial production      Oct.                        0.1%      0.1%
• Capacity utilization          Oct.                        75.9%    75.9%
• Industrial production      Nov.                      0.1%      NA
• Capacity utilization          Nov.                      76.0%    NA
• Consumer confidence

Henry’omics: We need to more than consider the market’s setting to grasp the micro re “our” universe of cell and gene therapy companies

• Monday: The Dow closed UP +227.79 points or +0.47%, the S&P closed UP +43.99 points or +0.64% while the Nasdaq closed UP +121.209 points or +0.52%
• Friday: The Dow closed UP +183.04 points or +0.38%, the S&P closed UP +59.74 points or +0.88% while the Nasdaq closed UP +301.26 points or +1.31%
• Last week: The S&P 500 was up +0.1%, the Dow slipped -0.7% and the Nasdaq was up +0.5%.
• The previous week: The S&P 500 was up +0.3%, the Dow +0.5% and the Nasdaq +0.9%.
• November ended: the S&P 500 and Dow were slightly higher, as the Nasdaq fell 2%,

Q4 – December, 7 positive and 9 negative closes

• November, 1 holiday, 8 positive and 11 negative sessions
• October, 1 neutral, 10 positive and 12 negative closes

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

• Not today, let the sector and market do their best or not?

The BOTTOM LINE: A volatile streak

Investors are hoping for continued momentum, as they gauge the prospects for a Santa Claus rally??

• Stocks are entering the final stretch of 2025 trading within striking distance their record highs, after a surprise drop in inflation and lukewarm labor market data left betting on possible 2026 interest-rate cuts

All 3 major indexes will enter the final 7 trading sessions of 2025 within 3% of their record highs.

• In the week ahead, those investors still around during the holidays will turn their attention to the prospects of a “Santa Claus rally,” while a few pieces of economic data out on Tuesday will clean up some of the lagging data delayed as a result of the government shutdown.

• Tuesday morning’s read on consumer confidence from the Conference Board should be the key focus, with one of 2025’s defining narratives centering on the K-shaped economy that has emerged among American shoppers.

Markets in the US will be open for half a day on Wednesday and closed on Thursday for Christmas. Many international markets will remain closed on Friday as well. <Yahoo Finance>

Welcome to my world of defining the “grey’ in our universe!

• With a downside end-of-month and year rotation and rebalance, In the last of December and 2025, it means investors have to be careful of slippage targets.

4^th and short week of December to include Christmas holiday

• Monday: Monday closed positive with 30 positive, 8 negative and 2 flats

3^rd week of December:

• 12/19 - Friday closed positive with 27 positive, 10 negative and 3 flats
• 12/18 – Thursday closed positive with 22 positive, 16 negative and 2 flats
• 12/17 – Wednesday closed negative with 12 positive, 26 negative and 2 flats
• 12/16- Tuesday closed negative with 17 positive, 21 negative and 2 flats
• 12/15 – Monday closed negative with 15 positive, 23 negative and 2 flats

As the leading voice of cell and gene therapy investors; I am NOT always a doom and gloom analyst/journalist but a man who has been “there” (BUY, SELL, VC and multiple operating roles) with the gray hair and a readership following with real numbers to prove it!

• I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC):

The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.