RMi Pre-opening: Sentiment succumbs

January 23, 2026 7:59am

Another econ continue to pile-on inflation data

TGIF after back-to-back gains on easing of one to another geopolitical fear possible Iranian action

I chose to speak-up when many analysts, brokers and commentators have shut-up!

Pre-open Signals: I am passing; If you understand probabilities, the inevitable is easier to maneuver

Never leave retail investor uninformed … I say what others won’t, so you can do what others can’t!

I make a commitment to provide need-to-know “facts in evidence” as an equity’s volatility is one tactical signal for stocks. My thesis is important in trying to distinguish the temporary from real pricing digression or progress

RMi Closing Bell: Share pricing regenerates … https://www.regmedinvestors.com/articles/14276

Friday: The pre-open Dow futures are DOWN -0.19% or (-95 points), the S&P futures are DOWN -0.06% or (-4.50 points) and the Nasdaq futures are DOWN -0.12% or (-30 points)

• U.S. stock futures fell on easing of geopolitical fears, Friday 1/23
• European markets flipped lower,
• Asia Pacific markets were up and at ‘em   

Economic Data: fewer …

• 10:00 am             Consumer sentiment (final)        
• 9:45 am                S&P flash U.S. services PMI      
• 9:45 am                S&P flash U.S. manufacturing PMI          

Henry’omics: We need to more than consider the market’s setting to grasp the micro re “our” universe of cell and gene therapy companies

• Thursday: The Dow closed UP +306.78 points or +0.63%, the S&P closed UP +37.73 points or +0.55% while the Nasdaq closed UP +211.195 points or +0.91%
• Wednesday: The Dow closed UP +588.64 points or +1.21%, the S&P closed UP +78.76 points or +1.16% while the Nasdaq closed UP +270.502 points or +1.18%
• Tuesday: The Dow closed DOWN -870.74 points or -1.76%, the S&P closed DOWN -143.15 points or -2.06% while the Nasdaq closed DOWN -561.065 points or -2.39%
• Monday was a market holiday
• Last Friday: The Dow closed DOWN -83.11 points or -0.17%, the S&P closed DOWN -4.46 points or -0.06% while the Nasdaq closed DOWN -14.634 points or -0.06%
• Last week: The S&P 500 was down -0.4%, the Dow -0.3% and the Nasdaq was down -0.7%.
• The previous week: The S&P 500 was up +1.6%, the Dow +2.3% and the Nasdaq was up +1.9%.

Q1/26 – Q1 – 2 holiday, 2 neutral, 4 negative and 5 positive closes  

Q4 – December,

• 1 holiday, 8 positive and 12 negative closes
• November, 1 holiday, 8 positive and 11 negative sessions
• October, 1 neutral, 10 positive and 12 negative closes

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

I’d say leave good-enough alone!

The BOTTOM LINE: Welcome to my world of defining the “grey’ in our universe!

Stock futures were falling on Friday as the 3 major indexes all racked up gains on Thursday, as geopolitical tensions surrounding the future status of Greenland appeared to ease.

• However as one easing geopolitical risk another appears - Iran??

Also, the Q4 and FY25 earnings cycle is about to appear beginning 2/5 and 2 more on 2/14

Welcome to my world of defining the “grey’ in our universe!

• I hate to be so negative or contrarian but, this is a NO spin zone and facts and truth are its products; I can always be WRONG but, I am mostly EARLY!
• if I wanted to be liked, I wouldn’t have been an analyst/journalist.

January 3^rd Week:

• 1/22 – Thursday closed positive with 33 incliners, 6 decliners and 1 flat
• 1/21- 1/21 – Wednesday closed positive with 33 incliners, 6 decliners and 1 flat
• 1/20 - Tuesday closed negative with 16 incliners, 22 decliners and 2 flats
• 1/19 – Monday was a holiday, MLK, Jr Day

January – 2nd week:

• 1/16 – Friday closed negative with 11 incliners, 28 decliners and 1 flat
• 1/8 – Thursday closed negative with 7 incliners, 30 decliners and 3 flats
• 1/7 – Wednesday closed positive with 33 incliners, 5 decliners and 2 flats
• 1/6 – Tuesday closed positive with 27 incliners, 11 decliners and 2 flats
• 1 /5 - Monday closed negative with 18 incliners, 21 decliners and 1 flat

As the leading voice of cell and gene therapy investors; I am NOT always a doom and gloom analyst/journalist but a man who has been “there” (BUY, SELL, VC and multiple operating roles) with the gray hair and a readership following with real numbers to prove it!

• I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC):

The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.