RMi Pre-opening: Don’t step on any cracks in the “random” walks

January 27, 2026 7:43am

Trouble is brewing for cell and gene sector therapies (CG&T) equities

As Q4/25 and FY25 earnings cycle approaches

Pre-open Signals: Passing today; If you understand probabilities, the inevitable is easier to maneuver

Never leave retail investor uninformed … I say what others won’t, so you can do what others can’t

I make a commitment to provide need-to-know “facts in evidence” as an equity’s volatility is one tactical signal for stocks. My thesis is important in trying to distinguish the temporary from real pricing digression or progress

RMi Closing Bell: Eyes on… https://www.regmedinvestors.com/articles/14283

I chose to speak-up when many analysts, brokers and commentators have shut-up!

Tuesday: The pre-open Dow futures are DOWN -0.47% or (-233 points), the S&P futures are UP +0.20% or (+14 points) and the Nasdaq futures are UP +0.58% or (+149 points)

• U.S. stock futures are mixed as S&P and Nasdaq puff-up, Tuesday, 1/27
• European markets rose with EU’s India trade “deal”
• Asia Pacific markets were in positive territory

Economic Data: Two

• 9:00 am                Case Shiller 20-city home price index     
• 10:00 am             Consumer confidence   

Henry’omics: We need to more than consider the market’s setting to grasp the micro re “our” universe of cell and gene therapy companies

• Monday: The Dow closed UP +313.69 points or +0.64%, the S&P closed UP +34.69 points or +0.50% while the Nasdaq closed UP +100.112 points or +0.43%
• Friday: The Dow closed DOWN -285.30 points or -0.58%, the S&P closed UP +2.26 points or +0.03% while the Nasdaq closed UP +65.225 points or +0.28%

• Last week: The S&P 500 was down -0.4%, the Dow -0.5% and the Nasdaq was down -0.1%.
• The previous week: The S&P 500 was down -0.4%, the Dow -0.3% and the Nasdaq was down -0.7%.

Q1/26 – Q1 – 2 holiday, 2 neutral, 5 negative and 6 positive closes  

Q4 – December,

• 1 holiday, 8 positive and 12 negative closes
• November, 1 holiday, 8 positive and 11 negative sessions
• October, 1 neutral, 10 positive and 12 negative closes

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

• NOT seeing it, leave well enogh alone

The BOTTOM LINE: Welcome to my world of defining the “grey’ in our universe!

• The S&P 500 and  Nasdaq looked set to cruise higher on Tuesday looking past or toward the threat of another government shutdown,
• More than 90 S&P 500 companies are slated to report quarterly earnings this week.
• They include “Magnificent Seven” giants Meta, Tesla and Microsoft — which are due Wednesday. Apple will share its results on Thursday.
• Earnings season has been strong so far, with about 3 out of 4 S&P 500 companies beating expectations, per FactSet.

Don’t overlook:

• Threats by Democrats in Congress to oppose funding the government beyond Jan. 30 due to the action of Immigration and Customs Enforcement agents have raised the odds of a shutdown above 70%, according to Jeremy Siegel, WisdomTree senior economist and an Emeritus Professor of Finance at the Wharton School of the University of Pennsylvania. <CNBC>

Also, the Q4 and FY25 earnings cycle is about to appear beginning 2/5 and 2 more on 2/14

• 2/5 – Arrowhead Pharmaceuticals (ARWR)
• 2/5 – IQVA Holdings (IQV)
• 2/12 - Vertex (VRTX)
• 2/13 – Moderna (MRNA)

Welcome to my world of defining the “grey’ in our universe!

• I hate to be so negative or contrarian but, this is a NO spin zone and facts and truth are its products; I can always be WRONG but, I am mostly EARLY!
• if I wanted to be liked, I wouldn’t have been an analyst/journalist.

Sector watch:

January – 5th week:

• Monday closed positive with 19 incliners, 18 decliners and 3 flats

January 4^rd Week:

• 1/23 – Friday closed negative with 6 incliners, 33 decliners and 1 flat
• 1/22 – Thursday closed positive with 33 incliners, 6 decliners and 1 flat
• 1/21- 1/21 – Wednesday closed positive with 33 incliners, 6 decliners and 1 flat
• 1/20 - Tuesday closed negative with 16 incliners, 22 decliners and 2 flats
• 1/19 – Monday was a holiday, MLK, Jr Day

As the leading voice of cell and gene therapy investors; I am NOT always a doom and gloom analyst/journalist but a man who has been “there” (BUY, SELL, VC and multiple operating roles) with the gray hair and a readership following with real numbers to prove it!

• I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC):

The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.