January 30, 2026 7:44am

Sucking the” breath” from the alternating share pricing sessions?

Whether or not Thursday's session was a blip; signs of excessive bullishness makes the C&GT sector susceptible to a sell-off

News: Moderna, Inc. (MRNA +$1.56 or +3.44% to $46.86) announced a strategic collaboration with Recordati to advance MRNA's investigational propionic acidemia (PA) therapeutic, mRNA-3927, through the final stages of clinical development and, upon approval, global commercialization. Recordati, based in Milan, Italy, is an international pharmaceutical group that provides treatments across specialty and primary care, and rare diseases, including PA. Through this agreement, MRNA will continue to lead the clinical development of mRNA-3927 through approval and Recordati will lead commercialization

Pre-open Signals: 1 Positive yet passing on others today; If you understand probabilities, the inevitable is easier to maneuver

Never leave retail investor uninformed … I say what others won’t, so you can do what others can’t!

 

I make a commitment to provide need-to-know “facts in evidence” as an equity’s volatility is one tactical signal for stocks. My thesis is important in trying to distinguish the temporary from real pricing digression or progress

RMi Closing Bell: Alternating endings … https://www.regmedinvestors.com/articles/14289

 

I chose to speak-up when many analysts, brokers and commentators have shut-up!

 

Friday: The pre-open Dow futures are DOWN -0.37% or (-185 points), the S&P futures are DOWN -0.36% or (-25 points) and the Nasdaq futures are DOWN -0.48% or (-124 points)

  • U.S. stock futures are low, Friday 1/30
  • European markets moved higher
  • Asia Pacific markets mostly fell

 

Economic Data: More …

  • 8:30 am                Producer price index (delayed report)    Dec.                       0.3%      0.2%
  • 8:30 am                Core PPI               Dec.                       0.3%      0.2%
  • 8:30 am                PPI year over year                                            --             3.0%
  • 8:30 am                Core PPI year over year                                 --             3.5%
  • 9:45 am                Chicago Business Barometer (PMI)           Jan.                        44.0        43.5
  • 1:00 pm               Fed Gov. Stephen Miran TV interview                                                    
  • 1:30 pm               St Louis Fed President Alberto Musalem speech                                                
  • 5:00 pm               Fed Vice Chair for Supervision Michelle Bowman speech               

 

Henry’omics: We need to more than consider the market’s setting to grasp the micro re “our” universe of cell and gene therapy companies

  • Thursday: The Dow closed UP +55.96 points or +0.11%, the S&P closed DOWN -9.02 points or -0.13% while the Nasdaq closed DOWN -172.327 points or -0.72%
  • Wednesday: The Dow closed UP +12.37 points or +0.03%, the S&P closed DOWN -0.56 points or -0.01% while the Nasdaq closed UP +40.349 points or +0.17%
  • Tuesday: The Dow closed DOWN -409.11 points or -0.83%, the S&P closed UP +28.34 points or +0.41% while the Nasdaq closed UP +215.742 points or +0.91%
  • Monday: The Dow closed UP +313.69 points or +0.64%, the S&P closed UP +34.69 points or +0.50% while the Nasdaq closed UP +100.112 points or +0.43%
  • Last week: The S&P 500 was down -0.4%, the Dow -0.5% and the Nasdaq was down -0.1%.
  • The previous week: The S&P 500 was down -0.4%, the Dow -0.3% and the Nasdaq was down -0.7%.

 

Q1/26 – Q1 – 2 holiday, 2 neutral, 8 negative and 9 positive closes  

Q4 – December,

  • 1 holiday, 8 positive and 12 negative closes
  • November, 1 holiday, 8 positive and 11 negative sessions
  • October, 1 neutral, 10 positive and 12 negative closes

 

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

  • Passing, could be wrong …but not about to grasping any buttons

 

The BOTTOM LINE: Welcome to my world of defining the “grey’ in our universe!

Despite recent volatility, major indexes remain higher for the week. The S&P 500 and Nasdaq are each up nearly 0.8% week to date, conversely the Dow (^DJI) is set to end the week down about 0.1%. <Yahoo Finance>

Since, the Q4 and FY25 earnings cycle is about to appear beginning 2/5 and more ...

  • 2/5 – Arrowhead Pharmaceuticals (ARWR)
  • 2/5 – IQVA Holdings (IQV)
  • 2/12 - Analylam Pharmaceuticals (ALNY) and Vertex (VRTX)
  • 2/13 – Moderna (MRNA)

 

Welcome to my world of defining the “grey’ in our universe!

  • I hate to be so negative or contrarian but, this is a NO spin zone and facts and truth are its products; I can always be WRONG but, I am mostly EARLY!
  • if I wanted to be liked, I wouldn’t have been an analyst/journalist.

 

January – 5th week:

  • 1/29 - Thursday closed positive with 22 incliners, 17 decliners and 1 flat
  • 1/28 - Wednesday closed negative with 4 incliners, 35 decliners and 1 flat
  • 1/27 - Tuesday closed positive with 21 incliners, 19 decliners and 0 flat
  • 1/26 -Monday closed positive with 19 incliners, 18 decliners and 3 flats

 

As the leading voice of cell and gene therapy investors; I am NOT always a doom and gloom analyst/journalist but a man who has been “there” (BUY, SELL, VC and multiple operating roles) with the gray hair and a readership following with real numbers to prove it!

  • I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

 

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC):

The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.