March 16, 2026 8:06am

Recovering from another losing week, with investors still monitoring oil prices
With all eyes on Wednesday’s Fed meeting

Pre-open Signals: 4 positive Indications

Earnings: Agenus (AGEN)

Remember that overnight action in futures don't necessarily translate into actual trading in today’s regular stock market session.

Never leave retail investor uninformed … I say what others won’t, so you can KNOW what others can’t!

 

 

Say/write less, mean more …

Friday’s RMi Closing Bell: Sentiment was conceded …

 https://www.regmedinvestors.com/articles/14348

RMi Research Note: Harvard Apparatus GT (OTCQB: HRGN): A new financing attempt, barely fulfills the need of a PPM raise … https://www.regmedinvestors.com/articles/13812

I chose to speak-up when many analysts, brokers and commentators have shut-up!

 

Monday: The pre-open Dow futures are UP +0.56% or (+262 points), the S&P futures are0.78% or ( +52.75 points) and the Nasdaq futures are UP +0.96% or (+236 points)

  • U.S. stock futures are on the rise, Monday 3/16
  • European markets initially fell but were up trending as session moved on
  • Asia Pacific markets were mixed

 

Economic Data: all ears will be flapping on Wednesday’s Fed meeting; Monday ‘s …

8:30 am                Empire State manufacturing survey         March                   4.1          7.1

9:15 am                Industrial production      Feb.                       0.1%      0.7%

9:15 am                Capacity utilization          Feb.                       76.2%    76.2%

 

Henry’omics: We need to more than consider the market’s setting to grasp the micro re “our” universe of cell and gene therapy companies

  • Friday: The Dow closed DOWN -119.38 points or -0.26%, the S&P closed DOWN -40.43 points or -0.61% while the Nasdaq closed DOWN -206.62 points or -0.94%
  • Thursday: The Dow closed DOWN -739.42 points or -1.56%, the S&P closed DOWN -103.18 points or -1.52% while the Nasdaq closed DOWN -404.155 points or -1.78%
  • Wednesday: The Dow closed DOWN -289.24 points or -0.61%, the S&P closed DOWN -5.68 points or -0.08% while the Nasdaq closed UP +19.031 points or +0.08%
  • Tuesday: The Dow closed DOWN -34.29 points or -0.07%, the S&P closed DOWN -14.49 points or -0.21% while the Nasdaq closed UP +1.158 points or +0.01%
  • Monday: The Dow closed UP +239.25 points or +0.50%, the S&P closed UP +55.97 points or +0.83% while the Nasdaq closed UP +308.267 points or +1.38%
  • Last week: The S&P 500 was down -1.6%, the Dow -2% and the Nasdaq was down -1.3%.
  • The previous week: The S&P 500 was down -2%, the Dow -0.3% and the Nasdaq was down -1.2%.
  • February: the Dow inclined +0.2%, the Nasdaq dived -3.3% and S&P 500 declined -1%.

 

Q1/26 – Q1 – March – 3 positive and 7 negative closes

  • February – 1 market holiday, 11 positive and 8 negative closes
  • January – 2 holiday, 2 neutral, 9 negative and 9 positive closes 

Q4/25:

  • December, 1 holiday, 8 positive and 12 negative closes
  • November, 1 holiday, 8 positive and 11 negative sessions
  • October, 1 neutral, 10 positive and 12 negative closes

 

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

  • One earnings coming as sector releases Qs and FY25 …

Vertex (VRTX) closed down -$8.79 after Thursday’s -$14.25 after Wednesday’s -$6.79 after Tuesday’s +$38.30 after Monday’s +$4.18 with a positive +$0.73 or +0.16% pre-open

Alnylam Pharmaceuticals (ALNY -$3.82 after Thursday’s -$3.20 after Wednesday’s -$1.95 after Tuesday’s -$1.21 after Monday’s +$2.93 with a positive +$0.57 or +0.18% pre-open

Ionis Pharmaceuticals (IONS) closed down -$1.15 after Thursday’s -$2.45 after Wednesday’s -$0.87 after Tuesday’s +$0.30 after Monday’s +$1.32 with a positive +$0.41 or +0.58% pre-open

Sarepta Therapeutics (SRPT closed down-$0.64 with a positive +$0.20 or +1.22% pre-open

 

The BOTTOM LINE: Welcome to my world of defining the “grey’ in our universe!

  • The 3 major indexes each marked their lowest close since November on Friday, dragged down by surging oil prices.

Stock futures are rising Monday on hopes that other countries would join the U.S. effort to secure safe passage through the Strait of Hormuz.

 

“I hate to be considered negative or contrarian but, this is a NO spin zone and truth is its product; I can always be WRONG but, I am mostly EARLY!”

Are the dice … hot, as they say it is STILL a “crap shoot”        

  • Keep that in mind   the latest batch of buying opportunities. If you take advantage, you have to be nimble, cutting losers quickly and not letting small winners turn into losers. 

 

My thoughts … OPEN the wallet – BUY - selectively!

 

Investors has been looking for further insight into sector earnings; the Q4 and FY25 earnings reporting cycle. So far …

  • Tuesday - 2/24 – AxoGen (AXGN), Beam Therapeutics (BEAM) and Supernus Therapeutics (SUPN)
  • Wednesday – 2/25 – MiMedx (MDXG), Ionis Pharmaceuticals (IONS) and Sarepta Therapeutics (SRPT)
  • Thursday – 2/26 – Intellia Therapeutics (NTLA), Wave Life Sciences (WVE), Mesoblast (MESO), Vericel (VCEL) and BioLife Solutions (BLFS)
  • Monday – 3/2 uniQure NV (QURE)
  • Thursday - 3/5 Regenxbio (RNX)
  • Tuesday – 3/10 – BioNTech, SE (BNTX)
  • Monday – 3/16 -Agenus (AGEN)

 

Welcome to my world of defining the “grey’ in our universe!

  • I hate to be so negative or contrarian but, this is a NO spin zone and facts and truth are its products; I can always be WRONG but, I am mostly EARLY!
  • if I wanted to be liked, I wouldn’t have been an analyst/journalist.

 

March – 2nd week

  • 3/13 – Friday closed negative with 11 incliner, 24 decliners and 5 flats
  • 3/12 – Thursday closed negative with 1 incliner, 36 decliners and 3 flats
  • 3/11 - Wednesday closed negative with 11 incliners, 26 decliners and 2 flats
  • 3/10 - Tuesday closed positive with 21 incliners, 16 decliners and 3 flats
  • 3/9 - Monday closed positive with 35 incliners, 2 decliners and 3 flats

March – 1st week

  • 3/6 - Friday closed negative with 14 incliners, 24 decliners and 2 flats
  • 3/5 – Thursday closed negative with 7 incliners, 32 decliners and 1 flat
  • 3 /4 – Wednesday closed positive with 32 incliners, 6 decliners and 2 flats
  • 3/3 - Tuesday closed negative with 2 incliners, 36 decliners and 2 flats
  • 3/2 - Monday closed negative with 15 incliners, 23 decliners and 3 flats

 

As the leading voice of cell and gene therapy investors; I am NOT always a doom and gloom analyst/journalist but a man who has been “there” (BUY, SELL, VC and multiple operating roles) with the gray hair and a readership following with real numbers to prove it!

  • I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

 

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC):

The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.