April 15, 2026 7:57am

US stocks are drifting lower before the bell on Wednesday

Reiterating, C&GT equities are STILL under a microscope during these times re their fair value until it’s clear that there is an end of the Iranian conflict.

Never say never, there could be a re-escalation and more downside from here; “uncle algo and his electronic trading dwarfs” are hungry

Pre-open signals: watch the flow and act accordingly – I’M STILL Holding

Never leave retail investor uninformed … I say what others won’t, so you can KNOW what others can’t!

 

 

Say/write less, mean more …

Tuesday’s RMi Closing Bell: Resilience … https://www.regmedinvestors.com/articles/14382

I chose to speak-up when many analysts, brokers and commentators have shut-up!

 

Remember that overnight action in futures don't necessarily translate into actual trading in today’s regular stock market session.

 

Wednesday: The pre-open Dow futures are DOWN -0.03% or (-49 points), the S&P futures are DOWN -0.01% or (-0.75 points) and the Nasdaq futures are DOWN -0.02% or (-4.250 pints)

  • U.S. stock futures are incrementally shrinking, Wednesday, 4/15
  • European equities and bourses were mixed
  • Asia Pacific markets traded higher

 

Economic Data: It’s still all about oil pricing

  • 8:30 am                Import price index           March                   2.4%      1.3%
  • 8:30 am                Import price index minus fuel     March                   --             1.1%
  • 8:30 am                Empire State manufacturing survey         April                       -0.5%     -0.2%
  • 8:30 am                Fed governor Michael Barr speaks                                                           
  • 8:30 am                Cleveland Fed President Beth Hammack TV appearance                                                
  • 10:00 am             Home builder confidence index April                       37           38
  • 1:45 pm               Fed Vice Chair for Supervision Michelle Bowman speaks                                                
  • 2:00 pm               Fed Beige Book

 

Henry’omics: We need to more than consider the market’s setting to grasp the micro re “our” universe of cell and gene therapy companies

  • Tuesday: The Dow closed UP +317.56 points or +0.60%, the S&P closed UP +81.15 points or +1.18% while the Nasdaq closed UP +455.347 points or +1.96%
  • Monday: The Dow closed UP +301.68 points or +0.63%, the S&P closed UP +69.35 points or +1.02% while the Nasdaq closed UP +280.842 points or +1.23%
  • Friday: The Dow closed DOWN -269.23 points or -0.56%, the S&P closed DOWN -7.77 points or -0.11% while the Nasdaq closed UP +80.477 points or +0.35%
  • Thursday: The Dow closed UP +275.88 points or +0.558%, the S&P closed UP +41.85 points or +0.62% while the Nasdaq closed UP +187.422 points or +0.83%
  • Wednesday: The Dow closed UP +1,325.46 points or +2.85%, the S&P closed UP +165.96 points or +2.51% while the Nasdaq closed UP +617.146 points or +2.80%
  • Last week: The S&P gained +3.6%, the Dow +3% and the Nasdaq ascended +4.7%
  • The previous week: the S&P advanced +3.4%, the Dow rose +3% and the Nasdaq dived -1.59%

 

 

Q2/26 – 1 neutral, 2 negative, 5 positive closes and 1 holiday

  • Q1 – March – 9 positive and 13 negative closes
  • February – 1 market holiday, 11 positive and 8 negative closes
  • January – 2 holiday, 2 neutral, 9 negative and 9 positive closes 

 

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

Let ‘em ride

 

The BOTTOM LINE: Welcome to my world of defining the “grey’ in our universe!

Econs, you know what they do ... while "uncle algo and his electronic trading dwarfs" are salivating

 

Welcome to my world of defining the “grey’ in our universe!

  • I hate to be so negative or contrarian but, this is a NO spin zone and facts and truth are its products; I can always be WRONG but, I am mostly EARLY!
  • if I wanted to be liked, I wouldn’t have been an analyst/journalist.


April 3rd Week:

  • 4/14 - Tuesday closed positive with 32 incliners, 6 decliners and 2 flats
  • 4/13 - Monday closed positive with 33 incliners, 5 decliners and 2 flats

April – 2nd week

  • 4/10 - Friday closed negative with 7 incliners, 30 decliners and 3 flats
  • 4/9 - Thursday closed positive with 24 incliners, 13 decliners and 3 flats
  • 4/8 – Wednesday closed positive with 27 incliners, 8 decliners and 5 flats
  • 4/7 – Tuesday closed negative with 15 incliners, 21 decliners and 4 flats
  • 4/6 - Monday closed positive with 20 incliners, 18 decliners and 2 flats

April – 1st week

  • 4/3 – Friday was a market holiday
  • 4/2 - Thursday closed neutral with 19 incliners, 19 decliners and 2 flats
  • 4/1 – Wednesday closed positive with 29 incliners, 8 decliners and 3 flats

 

Why do I keep repeating, framed in a different para, so investors can make the connection

The top three (3) performing in the session:    Winners

  • Tuesday: Alnylam Pharmaceuticals (ALNY), IQIA Holdings (IQV) and Vertex (VRTX)
  • Monday: Alnylam Pharmaceuticals (ALNY), IQIA Holdings (IQV) and Vertex (VRTX)
  • Friday: BioNTech (BNTX), Alnylam Pharmaceuticals (ALNY) and Beam Therapeutics (BEAM)

The worst three (3) in the session: Losers

  • Tuesday: uniQure NV (QURE), Precigen (PGEN) and Solid Biosciences (SLDB)
  • Monday: Arrowhead Pharmaceuticals (ARWR), Supernus Therapeutics (SUPN) and Ionis Pharmaceuticals (IONS)
  • Friday: Vertex (VRTX), IQIA Holdings (IQV) and Ionis Pharmaceuticals (IONS)

 

As the leading voice of cell and gene therapy investors; I am NOT always a doom and gloom analyst/journalist but a man who has been “there” (BUY, SELL, VC and multiple operating roles) with the gray hair and a readership following with real numbers to prove it!

  • I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

 

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC):

The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.