April 17, 2026 7:56am

With a comeback, after an indecisive purge after Tuesday and Monday’s surge

No Don Quixote as I continually ask, what do all these stock sources, I-Banks and brokers do for you in providing daily information? Availability of data have made intel both complex; I see myself as a collector and my responsibility is to further identify and interpret data to bridge some gaps in an investment decision.

Pre-open Signals: 1 Negative and 9 Positive Indications

Never leave retail investor uninformed … I say what others won’t, so you can KNOW what others can’t!

 

Say/write less, mean more …

Thursday’s RMi Closing Bell: Sector share pricing’s barrel roll … https://www.regmedinvestors.com/articles/14385   

I chose to speak-up when many analysts, brokers and commentators have shut-up!

 

Remember that overnight action in futures don't necessarily translate into actual trading in today’s regular stock market session.

 

Friday: The pre-open Dow futures are UP +0.44% or (+217 points), the S&P futures are UP +0.3% or (+21 points) and the Nasdaq futures are UP +0.25% or (+65 points)

  • U.S. stock futures inch higher, Friday, 4/17
  • European equities and bourses   were in the green
  • Asia Pacific markets traded to the downside

Economic Data: It’s still all about oil pricing

  • 2 Fed Presidents – talking heads and 1 Governor speak

 

Henry’omics: We need to more than consider the market’s setting to grasp the micro re “our” universe of cell and gene therapy companies

  • Thursday: The Dow closed UP +115.00 points or +0.24%, the S&P closed UP +18.33 points or +0.26% while the Nasdaq closed UP +86.687 points or +0.36%
  • Wednesday: The Dow closed DOWN -72.27 points or -0.17%, the S&P closed UP +55.57 points or +0.80% while the Nasdaq closed UP +378.9347 points or +1.60%
  • Tuesday: The Dow closed UP +317.56 points or +0.60%, the S&P closed UP +81.15 points or +1.18% while the Nasdaq closed UP +455.347 points or +1.96%
  • Monday: The Dow closed UP +301.68 points or +0.63%, the S&P closed UP +69.35 points or +1.02% while the Nasdaq closed UP +280.842 points or +1.23%
  • Last Friday: The Dow closed DOWN -269.23 points or -0.56%, the S&P closed DOWN -7.77 points or -0.11% while the Nasdaq closed UP +80.477 points or +0.35%
  • Last week: The S&P gained +3.6%, the Dow +3% and the Nasdaq ascended +4.7%
  • The previous week: the S&P advanced +3.4%, the Dow rose +3% and the Nasdaq dived -1.59%

 

Q2/26 – 1 neutral, 3 negative, 6 positive closes and 1 holiday

  • Q1 – March – 9 positive and 13 negative closes
  • February – 1 market holiday, 11 positive and 8 negative closes
  • January – 2 holiday, 2 neutral, 9 negative and 9 positive closes 

 

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

Let ‘em ride

 

Indications:

ARWR pre-open +$0.52

CAPR pre-open +$29

VRTX pre-open +$2.85

IQV pre-open +$1.54

SRPT pre-open +$0.38

CRSP pre-open +$0.68

BNTX pre-open +$1.22

ALNY pre-open +1.88

BEAM pre-open +$0.67

SUPN pre-open -0.18

 

The BOTTOM LINE: Welcome to my world of defining the “grey’ in our universe!

Sentiments sloppily yet a bit directional as … its pointing positive!

US stock futures, already at record highs, inched up Friday morning as US-Iran war tensions eased and earnings season got rolling.

  • Oil dropped …  Brent (BZ=F) fell toward $98 a barrel, paring a weekly gain, while West Texas Intermediate (CL=F) was near $93. Trump claimed, without evidence,
  • Tehran had agreed to terms it has long resisted, including opening the Strait of Hormuz. The Islamic Republic has not publicly confirmed the concessions.

Welcome to my world of defining the “grey’ in our universe!

  • I hate to be so negative or contrarian but, this is a NO spin zone and facts and truth are its products; I can always be WRONG but, I am mostly EARLY!
  • if I wanted to be liked, I wouldn’t have been an analyst/journalist.


April 3rd Week:

  • 4/16 - Thursday closed negative with 12 incliners, 26 decliners and 2 flats
  • 4/15 – Wednesday closed positive with 26 incliners, 12 decliners and 2 flats
  • 4/14 - Tuesday closed positive with 32 incliners, 6 decliners and 2 flats
  • 4/13 - Monday closed positive with 33 incliners, 5 decliners and 2 flats

April – 2nd week

  • 4/10 - Friday closed negative with 7 incliners, 30 decliners and 3 flats
  • 4/9 - Thursday closed positive with 24 incliners, 13 decliners and 3 flats
  • 4/8 – Wednesday closed positive with 27 incliners, 8 decliners and 5 flats
  • 4/7 – Tuesday closed negative with 15 incliners, 21 decliners and 4 flats
  • 4/6 - Monday closed positive with 20 incliners, 18 decliners and 2 flats

April – 1st week

  • 4/3 – Friday was a market holiday
  • 4/2 - Thursday closed neutral with 19 incliners, 19 decliners and 2 flats
  • 4/1 – Wednesday closed positive with 29 incliners, 8 decliners and 3 flats

 

Why do I keep repeating, framed in a different para, so investors can make the connection

The top three (3) performing in the session:    Winners

  • Thursday: BioNTech (BNTX), AxoGen (AXGN) and Compass Therapeutics (CMPX)
  • Wednesday: IQIA Holdings (IQV), Arrowhead Pharmaceuticals (ARWR) and Moderna (MRNA)
  • Tuesday: Alnylam Pharmaceuticals (ALNY), IQIA Holdings (IQV) and Vertex (VRTX)
  • Monday: Alnylam Pharmaceuticals (ALNY), IQIA Holdings (IQV) and Vertex (VRTX)
  • Last Friday: BioNTech (BNTX), Alnylam Pharmaceuticals (ALNY) and Beam Therapeutics (BEAM)

The worst three (3) in the session: Losers

  • Thursday: Alnylam Pharmaceuticals (ALNY), IQIA Holdings (IQV) and Vertex (VRTX)
  • Wednesday: Alnylam Pharmaceuticals (ALNY), Vertex (VRTX) and Sarepta Therapeutics (SRPT)
  • Tuesday: uniQure NV (QURE), Precigen (PGEN) and Solid Biosciences (SLDB)
  • Monday: Arrowhead Pharmaceuticals (ARWR), Supernus Therapeutics (SUPN) and Ionis Pharmaceuticals (IONS)
  • Last Friday: Vertex (VRTX), IQIA Holdings (IQV) and Ionis Pharmaceuticals (IONS)

 

As the leading voice of cell and gene therapy investors; I am NOT always a doom and gloom analyst/journalist but a man who has been “there” (BUY, SELL, VC and multiple operating roles) with the gray hair and a readership following with real numbers to prove it!

  • I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

 

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC):

The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.