April 22, 2026 7:51am

Ceasefire extension might lift Wednesday as Iran fires on ships and the US loads the return fire

Don’t forget, sector earnings begin

Pre-open Signals: HOLD most, with 3 Sell into Strength

Never leave retail investor uninformed … I say what others won’t, so you can KNOW what others can’t!

Let’s see how the news “plays out”

Say/write less, mean more …

Tuesday’s RMi Closing Bell: Waiting, yet again for conflict actions and market reaction … https://www.regmedinvestors.com/articles/14390   I chose to speak-up when many analysts, brokers and commentators have shut-up!

 

Remember that overnight action in futures don't necessarily translate into actual trading in today’s regular stock market session.

 

Wednesday: The pre-open Dow futures are UP +0.55% or (+270 points), the S&P futures are UP +0.55% (+38 points) and the Nasdaq futures are UP +0.69% or (+184 pints)

  • U.S. stock futures rose on ceasefire news, Wednesday, 4/22
  • European equities and bourses traded higher
  • Asia Pacific markets were mixed

Economic Data: It’s still all about oil pricing

  • NONE

 

Henry’omics: We need to more than consider the market’s setting to grasp the micro re “our” universe of cell and gene therapy companies

  • Tuesday: The Dow closed DOWN -293.18 points or -0.59%, the S&P closed DOWN -45.13 points or -0.63% while the Nasdaq closed DOWN -144.429 points or -0.59%
  • Monday: The Dow closed DOWN -4.87 points or -0.01%, the S&P closed DOWN -16.91 points or -0.24% while the Nasdaq closed DOWN -64.087 points or -0.26%
  • Last Friday: The Dow closed UP +868.71 points or +1.79%, the S&P closed UP +84.78 points or +1.20% while the Nasdaq closed UP +365.776 points or +1.52%
  • Last week: The S&P gained +3.6%, the Dow +3% and the Nasdaq ascended +4.7%
  • The previous week: the S&P advanced +3.4%, the Dow rose +3% and the Nasdaq dived -1.59%

 

Q2/26 – 1 neutral, 5 negative, 7 positive closes and 1 holiday

  • Q1 – March – 9 positive and 13 negative closes
  • February – 1 market holiday, 11 positive and 8 negative closes
  • January – 2 holiday, 2 neutral, 9 negative and 9 positive closes 

 

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

Sell into Strength:

BioNTech (BNTX) closed up +$6.41 after Monday’s +$2.27 after Friday’s +$0.80 with a positive +$0.59 or +0.53% pre-open

Capricor Therapeutics (CAPR +$1.13 after Monday’s -$0.49 with a positive +$0.61 or +1.73% pre-open

Intellia Therapeutics (NTLA) closed up +$0.10 after Monday’s +$0.26 after Friday’s +$0.79 with a positive +$0.22 or +1.46% pre-open

 

The BOTTOM LINE: Welcome to my world of defining the “grey’ in our universe!

Reiterating again, investors can a tank through the gaps in sentiment; the S&P 500 is at an all-time high, while consumer sentiment is at an all-time low.

Q1/26 Earnings Release Dates:

  • AxoGen (AXGN) – Tuesday, 4/28
  • Alnylam Pharmaceuticals (ALNY) -Thursday, 4/30
  • IQVIA Holdings (IQV) – Tuesday, 5/5

 

Welcome to my world of defining the “grey’ in our universe!

  • I hate to be so negative or contrarian but, this is a NO spin zone and facts and truth are its products; I can always be WRONG but, I am mostly EARLY!
  • if I wanted to be liked, I wouldn’t have been an analyst/journalist.


 

April 4th Week:

  • 4/21 – Tuesday closed negative with 5 incliners, 33 decliners and 2 flats
  • 4/20 - Monday closed negative with 16 incliners, 21 decliners and 3 flats

April 3rd Week:

  • 4/17 - Friday closed positive with 33 incliners, 5 decliners and 2 flats
  • 4/16 - Thursday closed negative with 12 incliners, 26 decliners and 2 flats
  • 4/15 – Wednesday closed positive with 26 incliners, 12 decliners and 2 flats
  • 4/14 - Tuesday closed positive with 32 incliners, 6 decliners and 2 flats
  • 4/13 - Monday closed positive with 33 incliners, 5 decliners and 2 flats

 

As the leading voice of cell and gene therapy investors; I am NOT always a doom and gloom analyst/journalist but a man who has been “there” (BUY, SELL, VC and multiple operating roles) with the gray hair and a readership following with real numbers to prove it!

  • I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

 

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC):

The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.