RMi Pre-opening: Effects versus affects?

April 29, 2026 8:04am

Will Fed chair Powell step-down? Will earnings and econs squeeze the “hopeful” upside?  Will the bond market test the 5% “danger zone” following sector equities losing their beat?

News: Intellia Therapeutics (NTLA -$1.14 pre-open to $12.06) priced its offering of 16,744,187 shares of its common stock to $10.75 per share. The gross proceeds are expected to be approximately $180 M, excluding any exercise of the underwriters' option to purchase additional shares. NTLA has granted the underwriters a 30-day option to purchase up to 2,511,628 additional shares of its common stock at the public offering price, less the underwriting discounts and commissions.

Earnings:  Alnylam Pharmaceuticals (ALNY) & Ionis Pharmaceuticals (IONS)

Never leave retail investor uninformed … I say what others won’t, so you can KNOW what others can’t!

Watch how the geo-pollical and macro news “plays out”

Say/write less, mean more …

Tuesday’s RMi Closing Bell: I’m still waving the red flag of caution … https://www.regmedinvestors.com/articles/14398

I chose to speak-up when many analysts, brokers and commentators have shut-up!

Remember that overnight action in futures don't necessarily translate into actual trading in today’s regular stock market session.

Wednesday: The pre-open Dow futures are UP +0.01% or (+3 points), the S&P futures are UP +0.05% (+3 points) and the Nasdaq futures are UP +0.33% or (+90 points)

• U.S. stock futures inch in their climb, Wednesday, 4/29
• European equities and bourses fell,
• Asia Pacific markets opened and closed mixed

Economic Data: It’s still all about oil pricing

• 8:30 am                Durable-goods orders    March                   0.2%                  -1.4%
• 8:30 am                Durable-goods minus transportation March                        0.8%
• 8:30 am                Housing starts (delayed report) Feb.       1.36 million      1.49 M
• 8:30 am                Building permits (delayed report) Feb.    1.39 million      1.38 M
• 8:30 am                Housing starts   March                                   1.40 million
• 8:30 am                Building permits              March                   1.39 M
• 8:30 am                Advanced U.S. trade balance in goods   March                   -$83.5 B
• 8:30 am                Advanced retail inventories       March                                   0.2%
• 8:30 am                Advanced wholesale inventories             March                   0.8%
• 2:00 pm               FOMC interest-rate decision                                                     
• 2:30 pm               Fed Chair Powell press conference         

Henry’omics: We need to more than consider the market’s setting to grasp the micro re “our” universe of cell and gene therapy companies

• Tuesday: The Dow closed DOWN -25.86 points or -0.05%, the S&P closed DOWN -35.08 points or -0.49% while the Nasdaq closed DOWN -223.301 points or -0.90%
• Monday: The Dow closed DOWN -62.92 points or -0.13%, the S&P closed UP +8.83 points or +0.12% while the Nasdaq closed UP +50.502 points or +0.20%
• Friday: The Dow closed DOWN -79.61 points or -0.16%, the S&P closed UP +56.68 points or +0.80% while the Nasdaq closed UP +398.094 points or +1.63%
• Thursday: The Dow closed DOWN -179.71 points or -0.36%, the S&P closed DOWN -29.50 points or -0.41% while the Nasdaq closed DOWN -219.063 points or -0.89%
• Wednesday: The Dow closed UP +340.65 points or +0.69%, the S&P closed UP +73.89 points or +1.05% while the Nasdaq closed UP +397.603 points or +1.64%

• Last week: The S&P 500 ended +0.5%, the Dow recorded a -0.4% decline and the Nasdaq rose +1.5%.
• The previous week: The S&P gained +3.6%, the Dow +3% and the Nasdaq ascended +4.7
• April so far: The S&P 500 is up more than 9%, while the Nasdaq has surged over 15% and the Dow has gained more than 6%.

Q2/26 – 1 neutral, 9 negative, 8 positive closes and 1 holiday

• Q1 – March – 9 positive and 13 negative closes
• February – 1 market holiday, 11 positive and 8 negative closes
• January – 2 holiday, 2 neutral, 9 negative and 9 positive closes 

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

…Dangerous times re share pricing

The BOTTOM LINE: Welcome to my world of defining the “grey’ in our universe!

Calm ahead …

The most widely followed gauge of market fear and uncertainty - the VIX was pretty much unchanged on Wednesday, suggesting calm ahead of looming "Big Tech" and 2 sector earnings layered by econ releases and the Fed's policy decision.

Q1/26 Earnings Release Dates:

• IQVIA Holdings (IQV) and Supernus Therapeutics (SUPN) – Tuesday, 5/5
• Vericel (VCEL) – Thursday, 5/7

Welcome to my world of defining the “grey’ in our universe!

• I hate to be so negative or contrarian but, this is a NO spin zone and facts and truth are its products; I can always be WRONG but, I am mostly EARLY!
• if I wanted to be liked, I wouldn’t have been an analyst/journalist.

April 5th Week:

• 4/28 – Tuesday closed negative with 17 incliners, 20 decliners and 3 flats
• 4/27 - Monday closed negative with 13 incliners, 24 decliners and 3 flats

April 4th Week:

• 4/24 – Friday closed negative with 11 incliners, 27 decliners and 2 flats
• 4/23 - Thursday closed negative with 7 incliners, 30 decliners and 3 flats
• 4/22 – Wednesday closed positive with 30 incliners, 9 decliners and 1 flat
• 4/21 – Tuesday closed negative with 5 incliners, 33 decliners and 2 flats
• 4/20 - Monday closed negative with 16 incliners, 21 decliners and 3 flats

As the leading voice of cell and gene therapy investors; I am NOT always a doom and gloom analyst/journalist but a man who has been “there” (BUY, SELL, VC and multiple operating roles) with the gray hair and a readership following with real numbers to prove it!

• I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC):

The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.