Indication intelligence, analysis and sector perception

RMi Research Note: Harvard Apparatus GT (OTCQB): Broke

November 12, 2025

Q3 net loss of -$1,700 or -$0.10 per share, cash position of $1.319 K and runway until 10/25 Revenue of $123 K (cost of dietary supplements sales: 112 K), accounts payable/outstanding debts to partners ($130 K to Yale University, $133 K to former employees), no clinical results, during Q3 recorded interest expense of approximately $7 K on convertible debt and approximately $4 K on insurance installment payments, recorded a 1-time offering cost loss totaling $500 K related to an anticipated offering that was not completed.Outstanding shares: 17,033,109. Ongoing Concern label still attached. Who is wasting lipstick on this pig? Challenging and questionable "aspects" state the obvious – a Ponzi Scheme! Accumulated deficit to date= $103.2 M in 12 years U.S. investors BEWARE, forewarned is forearmed?              

RMi Research Note: Fanning the faith, NVS to acquire RNA

October 26, 2025

A sector catalyst Novartis NVS) has agreed to buy Avidity Biosciences (RNA) closed up Friday +$0.60 or +1.24% to $49.15 for about $12 billion. NVS will pay Avidity shareholders $72 a share in cash, a premium of 46% to the company’s Friday closing price. Avidity Biosciences is a biopharmaceutical company. RNA is engaged in delivering a new class of ribonucleic acid (RNA) therapeutics called antibody oligonucleotide conjugates (AOCs). These AOCs are designed to combine the specificity of monoclonal antibodies with the precision of oligonucleotide therapies to address targets and diseases previously unreachable with existing RNA therapies.

RMi Note: Adverum Biotechnologies (ADVM) to be acquired for +$12.47 a share by Eli Lilly (LLY)

October 24, 2025

ADVM is up +$0.14 or +3.349% to $4.32 ADVM's lead program, Ixo-vec, is a P3 intravitreal gene therapy designed to treat vision loss associated with wet age-related macular degeneration with a single intravitreal dose Ixo-vec is designed as a single 1-time treatment to deliver continuous and stable intraocular aflibercept levels, thereby reducing the significant patient burden associated with current chronic anti-VEGF therapies, while also potentially leading to improved vision outcomes.