December 23, 2022 7:38am

Santa will deliver the gifts, the Fed tries to limit their quantity

Pre-open Indication: NONE

A daily report may say little or a lot and its final judgement may be inconclusive; yet it serves as insurance that all indications are being examined, evaluated and reported.

I write this blog/newsletter to inform investors with facts and supporting numbers focused on what they need to hear that others won’t say or write about - truth!

The Christmas holiday is starting for me with a limited review for the week, the 8:00 a.m. edition

Remember that overnight and pre-open actions in futures don't necessarily translate into actual trading in the coming day’s session.


Dow futures are UP +0.23% or (+74 points), S&P futures are UP +0.16% or (+6 point) and NASDAQ futures are UP +0.21% or (+22 points) early in the pre-open – so far,

Stock futures are edging up on Friday morning

European stocks tick higher as markets wind down for the holidays

Asia Pacific markets fall as Japan’s core inflation marks highest in over 40 years



We need to understand the macro to comprehend the micro re “our” universe of cell and gene therapy companies …

Indexes fell Thursday as a year-end sell-off returned following a brief respite this week.

  • Last night, the Dow closed DOWN -348.26 points (-1.04%), the S&P closed DOWN -55.84 points (-1.44%) while the Nasdaq closed DOWN -233.25 points (-2.18%)

Economic Data Docket: November’s personal consumption expenditure report — the Federal Reserve’s preferred measure of inflation — and personal income. New home sales and December consumer sentiment index


Thursday’s (9/22) … RegMed Investors’ (RMi) closing bell: “selling returned Thursday. I would also be more than worried by … about the upcoming quarter earnings season.” …

Ebb and flow:

Q4 – December – 10 negative and 6 positive closes

·         November -1 holiday, 14 negative and 8 positive closes

·         October -1 neutral, 11 positive and 9 negative closes

Q3/22 –

·         September – 1 holiday, 10 positive and 11 negative closes

·         August – 1 neutral, 11 positive and 11 negative closes

·         July - 1 holiday, 10 negative and 10 positive closes


Companies in my headlights – It’s your decision; I provide ideas and context: INDICATIONS

I am passing on any Positive or Negative indications – “Let ‘em ride”!

Although I foretell … some downside equity NEGATIVITY!


The BOTTOM LINE: I try to keep it simple and short!

The stock market and cell and gene therapy sector suffered losses Thursday, wiping out Wednesday's and Tuesday’s gains.

Be prepared … just 6 trading days remain in 2022.

Still, until December 31, investors may want to be cautious about making ANY buys.

Market exposure should be slim, limited only to positions that are working;  investors might want to take partial profits or simply exit some trades with a gain.

I’d be calculating selling for tax purposes amid the ongoing cell and gene therapy sector volatility, “our” universe’s trend remains " in a constant correction." That means that … lately we are investors are safer on the sidelines.

Insight is about understanding perception and also about putting into context what is relevant to expectation fulfillment,


Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice.

All investments are subject to risks. Investors should consider investment objectives.

Regulation Analyst Certification (Reg AC): The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and its or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed in this report.

Henry McCusker, the editor and publisher of RegMed Investors does not hold or have positions securities referred to in this publication.