August 23, 2023 7:36am

Investors await hints on the outlook for interest rates while fretting the probable of financings

If you’re looking for sector intel, ideas and facts or Insight in a volatile climate, RMi defines the extenuating factors of share pricing.

Pre-open Indications: 1 Negative, 1 Positive and 1 Sell into Strength

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8:00 a.m. edition

Remember that overnight and pre-open actions in futures don't necessarily translate into actual trading in the coming day’s session. My interpretation of the morning’s numbers is written to be informative; it’s built on what will happen behind the headlines today, not tomorrow or yesterday


Dow futures are UP +0.12% or (+41 point), S&P futures are UP +0.10% or (+4 points) and NASDAQ futures are UP +0.04% or (+6 points) early in the pre-open – so far

Stock futures climbed slowly higher on Wednesday as traders try to regain their footing following Tuesday’s mixed session,

European stock markets were higher,

Asia Pacific markets mixed as investors assess private business activity reports from Australia and Japan.



We need to more than consider the economic environment - rising rates and inflation to comprehend the micro re “our” universe of cell and gene therapy companies …

Tuesday, indexes closed mixed as the Dow closed DOWN -174.86 or -0.51%, the S&P closed DOWN -12.22 or -0.28% while the Nasdaq closed UP +8.28 points (+0.06%).

Traders are hoping to regain their footing following Tuesday’s session.

Economic Data Docket: new home sales and purchasing


Tuesday’s (8/22) RegMed Investors’ (RMi) closing bell: the cell and gene therapy sector wavers with a positive close.” …


Ebb and flow:

Q3: August – 5 positive and 11 negative closes

·         July - 1 holiday, 12 positive and 8 negative close

Q2/23 -

·         June -1 Holiday, 8 negative and 11 positive closes

·         May – 10 negative and 12 positive closes

·         April ended - 1 holiday, 8 positive close and 11 negative closes

Q1/23 –-

·         March – ended with 10 positive and 13 negative closes

·         February – 1 holiday, 2 vacation, 7 negative and 8 positive closes

·         January – 2 holidays, 11 positive and 9 negative closes


Companies in my headlights – It’s your decision; I provide ideas and context: INDICATIONS

I post about “indication intelligence” devoting my time to collection and analysis of information to assist investors with insight into sector vulnerabilities and strengths. A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

Sell into Strength:

Tuesday’s closing price, aftermarket dollar ($) and cent ($0.00) value and percentage (%)

AxoGen (AXGN) closed up +$0.41 with a negative $0.14 or -2.19% aftermarket indication


Positive Indication:

Tuesday’s closing price, aftermarket dollar ($) and cent ($0.00) value and percentage (%)

Beam Therapeutics (BEAM) closed down -$0.40 with a neutral $0.00 or pre-open indication


Negative Indication:

Tuesday’s closing price, aftermarket dollar ($) and cent ($0.00) value and percentage (%)

Ultragenyx Pharmaceuticals (RARE) closed down -$0.89 after Monday’s +$1.88 with a neutral or 0.00% pre-open indication



I follow the dictum, quoting Churchill that “short words are best, and the old words when short are best of all, as I try to keep it simple and short!

My “posts” are conveyed with a simplicity of language to highlight what is informative.

Let’s get to the point, few adverbs and even fewer adjectives, no vacillating; I get right to the point, telling investors what has meaning and why news or indications matter.

It “ain’t” been a good August for the cell and gene therapy sector as it suffers 4 positive and 11 negative closes so far.

I am NOT confident that some cell and gene therapy sector equities can continue ascending to the upside; unfortunately, it is a true “guessing” game!

Risk is riskier …

There's ALSO nothing wrong with standing pat in the short run, holding on to sizable existing exposure.

I hate to be so negative or contrarian but, this is a NO spin zone and truth is its product; I can always be WRONG but, I am mostly EARLY!


Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice.

All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.

Regulation Analyst Certification (Reg AC): The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and its or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed in this report.

Henry McCusker, the editor and publisher of RegMed Investors could hold or have positions securities referred to in this publication and he will NOTIFY investors of holdings.