RMi pre-open: Eyes open

October 9, 2025 7:52am

Uncertainty, volatility and risk assets increase as LPS (loss-per-share) earnings prepare for release

Still under the impression of “new highs, I say BYE”; as the government shutdown drags into its 9^th day, with the Senate once again rejecting dueling stopgap funding bills

News: a boost for “our” universe; Danish pharmaceutical, Novo Nordisk (NVO) plans to acquire biotech firm Akero Therapeutics (AKRO +$8.79 or +18.84% to $55.25). NVO will pay $54 per share, valuing Akero at $4.7 B, with the acquisition also including a contingent value right of $6 per share, potentially adding another $500 M to the offer.

Pre-open Signals: 3 Positive, 4 Negative and 2 Sell into Strength Indications

Never leave an investor uninformed … I say what others won’t, so you can do what others can’t!

Remember that overnight and pre-open actions’ futures and markets doesn’t necessarily translate into actual trading in today’s market session.

Wednesday night’s … RMi Closing Bell: Rack ‘em up … https://www.regmedinvestors.com/articles/14141

Is the stock market is caught up in an AI bubble remembering the late 1990s, when a feeding frenzy on early internet companies eventually led to the bursting of the dot-com bubble?

Thursday: The pre-open Dow futures are UP +0.05% or (+25 points), the S&P futures are UP +0.04% or (+2.75 points) and the Nasdaq futures are DOWN -0.02% or (-4 points)

• Futures are flipping and fallow mixed on Thursday, 8/9
• European markets were mixed
• Asia Pacific markets were mixed; South Korean markets were closed for a holiday

Henry’omics: We need to more than consider the markets …environment to comprehend the micro re “our” universe of cell and gene therapy companies

• Wednesday: The Dow closed DOWN -1.20 points or -0.00%, the S&P closed UP +39.13 points or +0.58% while the Nasdaq closed UP +255.015 points or +1.12%
• Tuesday: The Dow closed DOWN -82.16 points or -0.18%, the S&P closed DOWN -25.69 points or -0.38% while the Nasdaq closed DOWN -153.304 points or -0.67%
• Monday: The Dow closed DOWN -63.31 points or -0.14%, the S&P closed UP +24.49 points or +0.36% while the Nasdaq closed UP +161.161 points or +0.71%
• Last week, the Dow was up +1.3%, the S&P 500 is +1.1% and the Nasdaq has lost about 1.3%

• Last month and Q3’s numbers, the S&P 500 Q was up +7% and the month -4.2%, the Nasdaq’s Q is up +11% and the month +5% while the Dow’s Q is up +5% and the month +1%

Economic Data Docket: lots of Fed speakers, Jerome at 8:30 ET, 3 – vice-chairs and 2 presidents scramble to be relevant

Q4 – 4 positive and 2 negative closes

• Q3 – September, 1 holiday, 9 negative and 12 positive closes; August - 11 negative and 9 positive closes; July – 1 market holiday, 13 positive and 9 negative closes

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

• October begins with a government shutdown and fewer econs… along with the usual ups, downs and just plain uncertainties

Some indications in MY view:

Vertex (VRTX) closed up +$10.87 after Tuesday’s +$7.38 and Monday’s -$0.40 with a negative -$1.09 or -0.26% pre-open

CRISPR Therapeutics (CRSP) closed up +$6.16 after Tuesday’s +$0.43 and Monday’s +$2.45 with a negative -$0.18 or -0.23% pre-open

Intellia Therapeutics (NTLA) closed up +$4.03 with a negative -$0.15 or -0.61% pre-open

uniQure NV (QURE) closed up +$2.05 after Tuesday’s +$5.01 and Monday’s -$2.01 with a negative -$0.26 or -0.43% pre-open

Beam Therapeutics (BEAM +$1.87 after Tuesday’s -$0.76 and Monday’s +$0.14 with a positive +$0.10 or +0.37% pre-open

Regenxbio (RGNX) closed up +$1.71 with a positive +0.37 or +3.03% pre-open

Mesoblast (MESO) closed up +$1.66 after Tuesday’s +$0.77 and Monday’s -$1.09 with a neutral pre-open – Sell into Strength

BioLife Solutions (BLFS) closed up +$1.04 after Tuesday’s -$0.22 with a neutral pre-open – Sell into Strength

Supernus Therapeutics (SUPN) closed down -$0.07 after Tuesday’s -$0.24 with a positive +$200 or +4.17% pre-open

The BOTTOM LINE: I can’t seem to let go of this quote, “It’s always darkest before the pitch dark”

Reiterating, “What to Do Now: The stock market with the major indexes all near record highs … “uncle algo and his electronic trading dwarfs” are smelling some FURTHER profits!”

Indexes capped off Wednesday's session mixed: the Nasdaq rallied by over 1.1%, the S&P 500 +0.58%, while the Dow fell -1.20 points or -0.00%

The Fed's September FOMC meeting points to interest rate cuts to come in Q4/2025.

Welcome to my world of defining the “grey’ in our universe!

• I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

October: understand the new “flow” …

This week:

• 10/8 – Wednesday closed positive with 29 positive, 10 negative and 1 flat
• 10/7 – Tuesday closed negative with 15 positive, 25 negative and 0 flat
• 10/6 – Monday closed negative with 17 positive, 22 negative and 1 flat

Last week:

• 10/3 – Friday closed positive with 27 positive, 10 negative and 3 flats
• 10/2 – Thursday closed positive with 26 positive, 13 negative and 1 flat
• 10/1 – Wednesday closed positive with 26 positive, 14 negative and 0 flat
• 9/30 -- Tuesday closed positive with 24 positive, 15 negative and 1 flat
• 9/29 – Monday closed positive with 33 positive, 5 negative and 2 flats

Q3 Earnings are in the front-view mirror; we are about to start again …!

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC):

The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.