October 14, 2025 7:51am

Watch-out, after dramatic upside return from Friday’s (10/13) advance/decline (A/D) line of 3 positive, 37 negative and 0 flat versus Monday’s (10/13) 20 positive, 20 negative and 0 flat

While The Cboe Volatility Index (VIX) registered at 19.05, down 12.06% Monday

News: Rocket Pharmaceuticals (RCKT +$0.20 or +5.76 to $3.67 pre-open) FDA Accepts BLA resubmission of KRESLADI™ for the treatment of Severe Leukocyte Adhesion Deficiency-I (LAD-I)

Pre-open Signals: 2 Positive and 5 Negative Indications

If you understand the possibilities, the inevitable is easier to maneuver

Never leave an investor uninformed … I say what others won’t, so you can do what others can’t!

 

With a market high, a volatility spike with a dramatic momentum happens; indexes followed by the C&GT (cell and gene therapy) sector becomes a “bull trap” or possibility of a signal to a declining trend that reverses after a strong rally, breaking prior support

Monday night’s … RMi Closing Bell: Impact … https://www.regmedinvestors.com/articles/14148

Remember that overnight and pre-open actions’ futures and markets doesn’t necessarily translate into actual trading in today’s market session.

 

Tuesday: The pre-open Dow futures are DOWN -0.51% or (-237 points), the S&P futures are DOWN -0.83% or (-55 points) and the Nasdaq futures are also DOWN -1.11% or (-276 points)

  • Stock futures fell Tuesday, 10/14
  • European stocks moved lower,
  • Asia-Pacific markets mostly fell

 

News (continued): KRESLADI™ is an investigational gene therapy that contains autologous (patient-derived) hematopoietic stem cells that have been genetically modified with a lentiviral (LV) vector to deliver a functional copy of the ITGB2 gene, which encodes for the beta-2 integrin component CD18, a key protein that facilitates leukocyte adhesion and enables their extravasation from blood vessels to fight infection.

 

Henry’omics: We need to more than consider the markets …environment to comprehend the micro re “our” universe of cell and gene therapy companies

  • Monday: The Dow closed UP +587.98 points or +1.29%, the S&P closed UP +102.21 points or +1.56% while the Nasdaq closed UP +490.178 points or +2.21%
  • Friday: The Dow closed DOWN -878.82 points or -1.92%, the S&P closed DOWN -182.60 points or -2.71% while the Nasdaq closed DOWN -820.196 points or -3.56%
  • Last week: the Dow was down -2%, the S&P down -1% and the Nasdaq +1%,
  • The previous week, the Dow was up +1.3%, the S&P 500 +1.1% while the Nasdaq lost -1.3%
  • Last month and Q3’s numbers, the S&P 500 Q was up +7% and the month -4.2%, the Nasdaq’s Q is up +11% and the month +5% while the Dow’s Q is up +5% and the month +1%

 

Q4 – 1 neutral, 5 positive and 3 negative closes

  • Q3 – September, 1 holiday, 9 negative and 12 positive closes; August - 11 negative and 9 positive closes; July – 1 market holiday, 13 positive and 9 negative closes

 

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

  • October began with a government shutdown and much fewer econs… along with the usual ups, downs
  • Now uncertainty rules

Although:

IQV Holdings (IQV) closed up +$5.60 after Friday -$4.83 with a negative -$0.34 or -0.17% preopen

Alnylam Pharmaceuticals (ALNY) closed up +$4.80 after Friday +$3.5 with a positive +$0.68 or 0.15% pre-open

Vericel (VCEL) closed up +$1.64 with a negative -$1.19 or -3.55% pre-open

Arrowhead Pharma (ARWR) closed up +$0.84 with a negative -$0.95 or -2.62% pre-open

uniQure NV (QURE) closed up +$0.57 after Friday -$2.10 with a negative -$0.72 or -1.16% pre-open

Regenxbio (RGNX) closed up +$0.47 after Friday -$1.25 with a negative -$0.14 or -1.23% pre-open

 

The BOTTOM LINE: Monday, they (investors, hedges, traders and electronic machine trading) bought the dip!

The shutdown entered its 14th day on Tuesday, with lawmakers still unable to agree on a funding bill.

The Bureau of Labor Statistics has recalled some staff to prepare the CPI report before the Oct. 28-29 Federal Reserve policy meeting. The September CPI also is needed to determine the annual cost of living increase for Social Security.

Welcome to my world of defining the “grey’ in our universe!

  • I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

 

October: understand the new “flow” …

Current week:

  • 10/13 – Monday closed neutral with 20 positive, 20 negative and 0 flat

Last week:

  • 10/10 - Friday closed negative with 3 positive, 37 negative and 0 flat
  • 10/9 - Thursday closed positive with 21 positive, 19 negative and 0 flat
  • 10/8 – Wednesday closed positive with 29 positive, 10 negative and 1 flat
  • 10/7 – Tuesday closed negative with 15 positive, 25 negative and 0 flat
  • 10/6 – Monday closed negative with 17 positive, 22 negative and 1 flat

The start of October:

  • 10/3 – Friday closed positive with 27 positive, 10 negative and 3 flats
  • 10/2 – Thursday closed positive with 26 positive, 13 negative and 1 flat
  • 10/1 – Wednesday closed positive with 26 positive, 14 negative and 0 flat

Q3 Earnings are in the front-view mirror; we are about to start again …!

 

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC):

The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.