RMi pre-open: BYE

October 17, 2025 8:03am

Many of Thursday’s ups are Friday’s downs

Sector Q3 earnings begin with IQV Holdings (IQV) on 10/28, MiMedx (MDXG) Ionis Pharmaceuticals IONS), AxoGen AXGN) on 10/29 with Moderna (MRNA) on 11/6

Pre-open Signals: 1 Positive and 10 Negative Indications

If you understand the possibilities, the inevitable is easier to maneuver

Never leave an investor uninformed … I say what others won’t, so you can do what others can’t!

Thursday night’s … RMi Closing Bell: Chilly … https://www.regmedinvestors.com/articles/14153

Remember that overnight and pre-open actions’ futures and markets doesn’t necessarily translate into actual trading in today’s market session.

RMi Research Note: Harvard Apparatus GT (OTCQB): Who is wasting lipstick on this pig? … https://www.regmedinvestors.com/articles/13812

Friday: The pre-open Dow futures are DOWN -0.18% or (-85 points), the S&P futures are DOWN -0.39% or (-26 points) and the Nasdaq futures are DOWN -0.61% or ( -152 points)

U.S. stock futures fell on Friday, 10/17

European markets traded in the red,

Asia Pacific markets were mixed mostly in the red

Henry’omics: We need to more than consider past market closes … to comprehend the micro re “our” universe of cell and gene therapy companies

• Thursday: The Dow closed DOWN -301.07 points or -0.65%, the S&P closed DOWN -41.99 points or -0.63% while the Nasdaq closed DOWN -107.542 points or -0.47%
• Wednesday: The Dow closed DOWN -17.15 points or -0.04%, the S&P closed UP +26.75 points or +0.40% while the Nasdaq closed UP +148.379 points or +0.66%
• Tuesday: The Dow closed UP +202.88 points or +0.44%, the S&P closed DOWN -10.41 points or -0.16% while the Nasdaq closed DOWN -172.907 points or -0.76%
• Monday: The Dow closed UP +587.98 points or +1.29%, the S&P closed UP +102.21 points or +1.56% while the Nasdaq closed UP +490.178 points or +2.21%
• This week to date: the S&P 500 is up +1.2%, the Dow added +1% week to date, while the Nasdaq gained +1.6%.
• Last week: the Dow was down -2%, the S&P down -1% and the Nasdaq +1%,
• The previous week, the Dow was up +1.3%, the S&P 500 +1.1% while the Nasdaq lost -1.3%
• Last month and Q3’s numbers, the S&P 500 Q was up +7% and the month -4.2%, the Nasdaq’s Q is up +11% and the month +5% while the Dow’s Q is up +5% and the month +1%

Q4 – 1 neutral, 7 positive and 4 negative closes

• Q3 – September, 1 holiday, 9 negative and 12 positive closes; August - 11 negative and 9 positive closes; July – 1 market holiday, 13 positive and 9 negative closes

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

• October began with a government shutdown and much fewer econs… along with the usual ups, downs
• Now uncertainty rules

Although:

Alnylam Pharmaceuticals (ALNY) closed up +$10.80 with a negative -$7.11 or -1.48% pre-open

IQV Holdings (IQV) closed up +$2.67 after Wednesday -$1.64, Tuesday’s +$0.87 and Monday +$5.60 with a negative -$1.78 or -0.86% pre-open

Sarepta Therapeutics (SRPT) closed up +$1.14 with a negative -$0.53 or -2.27% pre-open

Arrowhead Pharma (ARWR +$0.78 after Wednesday +$2.23, Tuesday -$0.29 and Monday’s +$0.84 with aa negative -$0.43 or -1.10% pre-open

BioNTech (BNTX) closed up +$0.74 after Wednesday +$1.73 with a negative -$1.45 or -1.38% pre-open

Vertex (VRTX) closed up +$0.71 after Wednesday’s -$4.32, Tuesday’s +$4.85 and Monday +$0.42 with a positive +$1.42 or +0.35% pre-open

Ionis Pharmaceuticals (IONS) closed up +$0.68 with a negative -$0.02 or -0.03% pre-open

Ultragenyx Pharmaceuticals (RARE) closed up +$0.54 with a negative -$0.17 or -0.50% pre-open

CRISPR Therapeutics (CRSP) closed down -$7.39 after Wednesday’s +$2.44, Tuesday +$1.09 and Monday -$4.81 with a negative -$1.48 or -2.16% pre-open

uniQure NV (QURE -$2.84 after Wednesday’s +$3.87, Tuesday -$3.06 and Monday’s +$0.57 with a negative -$0.08 or -0.13% pre-open

Capricor Therapeutics (CAPR) closed -$0.53 after Wednesday’s -$0.01, Tuesday’s -$0.02 and Monday’s -$0.37 with a negative -$0.17 or -2.76% pre-open

The BOTTOM LINE: I am staying with my mantra …“It’s always darkest before the pitch dark”

The shutdown enters its 17^th day on Friday, with lawmakers still unable to agree on a funding bill.

Welcome to my world of defining the “grey’ in our universe!

• I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

October: understand the new “flow” …

Current week:

• 10/16 - Thursday closed negative with 17 positive, 22 negative and 1 flat
• 10/15 - Wednesday closed positive with 31 positive, 9 negative and 1 flat
• 10/14 - Tuesday closed positive with 28 positive, 12 negative and 0 flat
• 10/13 – Monday closed neutral with 20 positive, 20 negative and 0 flat

Last week:

• 10/10 - Friday closed negative with 3 positive, 37 negative and 0 flat
• 10/9 - Thursday closed positive with 21 positive, 19 negative and 0 flat
• 10/8 – Wednesday closed positive with 29 positive, 10 negative and 1 flat
• 10/7 – Tuesday closed negative with 15 positive, 25 negative and 0 flat
• 10/6 – Monday closed negative with 17 positive, 22 negative and 1 flat

The start of October:

• 10/3 – Friday closed positive with 27 positive, 10 negative and 3 flats
• 10/2 – Thursday closed positive with 26 positive, 13 negative and 1 flat
• 10/1 – Wednesday closed positive with 26 positive, 14 negative and 0 flat

Q3 Earnings are in the front-view mirror; we are about to start again …!

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC):

The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.