RMi pre-open: Fait accompli

October 29, 2025 8:00am

Sector earnings releases and interest rate decision

Today: MiMedx (MDXG), Ionis Pharmaceuticals IONS and AxoGen (AXGN)

Traders have a nearly 100% probability that the FOMC will approve a 2^nd consecutive ¼ percentage point at its meeting this week

Pre-open Signals: 7 Positive and 2 Negative Indications

Never leave an investor uninformed … I say what others won’t, so you can do what others can’t!

Short on words, long on being judiciously predictive!

Tuesday night’s … RMi Closing Bell: Skidding … https://www.regmedinvestors.com/articles/14169   

Remember that overnight and pre-open actions’ futures and markets doesn’t necessarily translate into actual trading in today’s market session.

Wednesday: The pre-open Dow futures are UP +0.19% or (+93 points), the S&P futures are UP +0.31% or (+21 points) and the Nasdaq futures are UP +0.49% or (+127 points)

• Stock futures are staying positive Wednesday, 10/29
• European markets paced higher,
• Asia Pacific markets traded mixed.

Henry’omics: We need to more than consider the market’s setting to grasp the micro re “our” universe of cell and gene therapy companies

• Tuesday: The Dow closed UP +161.78 points or +0.34%, the S&P closed UP +15.76 points or +0.23% while the Nasdaq closed UP +190.037 points or +0.80%
• Monday: The Dow closed UP +337.47 points or +0.71%, the S&P closed UP +83.47 points or +1.23% while the Nasdaq closed UP +432.589 points or +1.86%
• Last week: the S&P 500 is up +2%, the Dow +2% and the Nasdaq added +2%.
• The previous week: the S&P 500 was up +1.7%, the Dow +1.6% and the Nasdaq +2.1%.
• Last month and Q3’s numbers, the S&P 500 Q was up +7% and the month -4.2%, the Nasdaq’s Q is up +11% and the month +5% while the Dow’s Q is up +5% and the month +1%

Economic Data Docket:

Q4 – 1 neutral, 9 positive and 10 negative closes

• Q3 – September, 1 holiday, 9 negative and 12 positive closes; August - 11 negative and 9 positive closes; July – 1 market holiday, 13 positive and 9 negative closes

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

• October began with a government shutdown and much fewer econs… along with the usual ups, downs
• Now uncertainty rules

Info:

Vertex (VRTX) closed up +$2.22 after Monday’s-$1.22 with a negative -$3.82 or -0.91% pre-open

IQVIA Holdings (IQV) closed up +$0.64 after Monday’s -$3.15 with a positive +$0.92 or +0.42% pre-open

Ionis Pharmaceuticals (IONS) closed up +$0.58 after Monday’s +$2.13 with a positive +$0.43 or +0.58% pre-open

AxoGen (AXGN) closed up +$0.31 after Monday’s -$0.40 with a positive +$0.59 or +3.26% pre-open

Alnylam Pharmaceuticals (ALNY) closed down -$2.67 after Monday’s +$15.15 with aa negative -$1.90 or -0.40% pre-open

CRISPR Therapeutics (CRSP) closed down -$1.55 after Monday’s -$1.89 with a positive +$0.24 or +0.37% pre-open

Moderna (MRNA) closed down -$1.31 with a positive +$0.18 or +0.71% pre-open

BioNTech (BNTX) closed down -$1.02 after Monday’s +$0.39 with a positive +$0.51 or +0.49% pre-open

Lenz Therapeutics (LENZ) closed down -$0.48 after Monday’s -$0.68 with a positive +$1.08 or +3.51% pre-open

The BOTTOM LINE: I’m getting on my horse with a lantern as I ride yelling … “earnings are here, earnings are here”!

Q3 Earnings are in the front-view mirror this week …!

• Vertex (VRTX) and Sarepta Therapeutics (SUPN) on 11/3, Ultragenyx Pharmaceuticals (RARE), Supernus Therapeutics (SUPN) on 11/4 followed by Regenxbio (RGNX), Moderna (MRNA) and Vericel (VCEL)

Expect earnings’ results that meet, beat or miss revenue estimates, EPS as to pricing expectations, consensus … sector earnings while LPS (loss-per-share) assumes adjustments

News, not so bad, good or no news … in the coming week is a reason to consider adding or subtract as needed to “portfolio exposure” as proximity to earnings release come to appear …

• If the Fed meeting and trade talks are positive catalysts, investors will want to get more aggressive.
• As sector earnings meet, beat or miss expectations; whipsaw actions could ensue depreciations or the stock market heads south, back pedal -- fast.

Upcoming;

• Sarepta Therapeutics (SRPT) is soon to post loss of $0.03 per share forQ3/25. This estimate indicates a year-over-year change of -104.8%. This Q3's revenue is expected to be $346.23 million, down 25.9% from the year-ago quarter.
• Ultragenyx Pharmaceuticals (RARE) is expected to post a Q3 loss of $0.85 per share which represents a year-over-year change of +6.6%. Revenues are expected to be $6.93 million, up 202.6% from the year-ago quarter
• uniQure NV (QURE) is expected to post quarterly loss of $0.85 per share in its upcoming report, which represents a year-over-year change of +6.6%Revenues are expected to be $6.93 million, up 202.6% from the year-ago quarter.

The shutdown enters its 29^th day today, with lawmakers still unable to agree on a funding bill … as Democrats block the 13th voting negotiation

Welcome to my world of defining the “grey’ in our universe!

• “I hate to be so negative or contrarian but, this is a NO spin zone and truth is its product; I can always be WRONG but, I am mostly EARLY!”
• I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

October: understand the new “flow” …

New week:

• 10/28 -Tuesday closed negative with 16 positive, 21 negative and 3 flats
• 10/27- Monday closed negative with 18 positive, 22 negative and 0 flats

Last week:

• 10/24 - Friday closed positive with 25 positive, 13 negative and 2 flats
• 10/23 – Thursday closed negative with 15 negative, 22 negative and 3 flats
• 10/22 – Wednesday closed negative with 4 positive, 34 negative and 2 flat
• 10/21 - Tuesday closed negative with 17 positive, 23 negative and 0 flat
• 10/20 - Monday closed positive with 34 positive, 4 negative and 2 flats

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC):

The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.